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Novel Neuroprotective Strategies in Ischemic Retinal Lesions
Department of Experimental Zoology and Neurobiology, University of Pecs, H-7624 Pecs, Hungary
Department of Biochemistry and Medical Chemistry, University of Pecs, H-7624 Pecs, Hungary
Department of Anatomy, University of Pecs, H-7624 Pecs, Hungary
Department of Sportbiology, University of Pecs, H-7624 Pecs, Hungary
* Author to whom correspondence should be addressed.
Received: 7 January 2010; in revised form: 27 January 2010 / Accepted: 27 January 2010 / Published: 3 February 2010
Abstract: Retinal ischemia can be effectively modeled by permanent bilateral common carotid artery occlusion, which leads to chronic hypoperfusion-induced degeneration in the entire rat retina. The complex pathways leading to retinal cell death offer a complex approach of neuroprotective strategies. In the present review we summarize recent findings with different neuroprotective candidate molecules. We describe the protective effects of intravitreal treatment with: (i) urocortin 2; (ii) a mitochondrial ATP-sensitive K+ channel opener, diazoxide; (iii) a neurotrophic factor, pituitary adenylate cyclase activating polypeptide; and (iv) a novel poly(ADP-ribose) polymerase inhibitor (HO3089). The retinoprotective effects are demonstrated with morphological description and effects on apoptotic pathways using molecular biological techniques.
Keywords: BCCAO; ischemia; retinoprotection; urocortin 2; diazoxide; PACAP; PARP-inhibitor; rat retina
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Szabadfi, K.; Mester, L.; Reglodi, D.; Kiss, P.; Babai, N.; Racz, B.; Kovacs, K.; Szabo, A.; Tamas, A.; Gabriel, R.; Atlasz, T. Novel Neuroprotective Strategies in Ischemic Retinal Lesions. Int. J. Mol. Sci. 2010, 11, 544-561.
Szabadfi K, Mester L, Reglodi D, Kiss P, Babai N, Racz B, Kovacs K, Szabo A, Tamas A, Gabriel R, Atlasz T. Novel Neuroprotective Strategies in Ischemic Retinal Lesions. International Journal of Molecular Sciences. 2010; 11(2):544-561.
Szabadfi, Krisztina; Mester, Laszlo; Reglodi, Dora; Kiss, Peter; Babai, Norbert; Racz, Boglarka; Kovacs, Krisztina; Szabo, Aliz; Tamas, Andrea; Gabriel, Robert; Atlasz, Tamas. 2010. "Novel Neuroprotective Strategies in Ischemic Retinal Lesions." Int. J. Mol. Sci. 11, no. 2: 544-561.