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Int. J. Mol. Sci. 2010, 11(2), 544-561; doi:10.3390/ijms11020544
Review

Novel Neuroprotective Strategies in Ischemic Retinal Lesions

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1 Department of Experimental Zoology and Neurobiology, University of Pecs, H-7624 Pecs, Hungary 2 Department of Biochemistry and Medical Chemistry, University of Pecs, H-7624 Pecs, Hungary 3 Department of Anatomy, University of Pecs, H-7624 Pecs, Hungary 4 Department of Sportbiology, University of Pecs, H-7624 Pecs, Hungary
* Author to whom correspondence should be addressed.
Received: 7 January 2010 / Revised: 27 January 2010 / Accepted: 27 January 2010 / Published: 3 February 2010
(This article belongs to the Special Issue Neuroprotective Strategies (special issue))
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Abstract

Retinal ischemia can be effectively modeled by permanent bilateral common carotid artery occlusion, which leads to chronic hypoperfusion-induced degeneration in the entire rat retina. The complex pathways leading to retinal cell death offer a complex approach of neuroprotective strategies. In the present review we summarize recent findings with different neuroprotective candidate molecules. We describe the protective effects of intravitreal treatment with: (i) urocortin 2; (ii) a mitochondrial ATP-sensitive K+ channel opener, diazoxide; (iii) a neurotrophic factor, pituitary adenylate cyclase activating polypeptide; and (iv) a novel poly(ADP-ribose) polymerase inhibitor (HO3089). The retinoprotective effects are demonstrated with morphological description and effects on apoptotic pathways using molecular biological techniques.
Keywords: BCCAO; ischemia; retinoprotection; urocortin 2; diazoxide; PACAP; PARP-inhibitor; rat retina BCCAO; ischemia; retinoprotection; urocortin 2; diazoxide; PACAP; PARP-inhibitor; rat retina
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Szabadfi, K.; Mester, L.; Reglodi, D.; Kiss, P.; Babai, N.; Racz, B.; Kovacs, K.; Szabo, A.; Tamas, A.; Gabriel, R.; Atlasz, T. Novel Neuroprotective Strategies in Ischemic Retinal Lesions. Int. J. Mol. Sci. 2010, 11, 544-561.

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