Int. J. Mol. Sci. 2010, 11(2), 544-561; doi:10.3390/ijms11020544

Novel Neuroprotective Strategies in Ischemic Retinal Lesions

1email, 2email, 3email, 3email, 1email, 2email, 2email, 2email, 3email, 1email and 1,4,* email
Received: 7 January 2010; in revised form: 27 January 2010 / Accepted: 27 January 2010 / Published: 3 February 2010
(This article belongs to the Special Issue Neuroprotective Strategies)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Retinal ischemia can be effectively modeled by permanent bilateral common carotid artery occlusion, which leads to chronic hypoperfusion-induced degeneration in the entire rat retina. The complex pathways leading to retinal cell death offer a complex approach of neuroprotective strategies. In the present review we summarize recent findings with different neuroprotective candidate molecules. We describe the protective effects of intravitreal treatment with: (i) urocortin 2; (ii) a mitochondrial ATP-sensitive K+ channel opener, diazoxide; (iii) a neurotrophic factor, pituitary adenylate cyclase activating polypeptide; and (iv) a novel poly(ADP-ribose) polymerase inhibitor (HO3089). The retinoprotective effects are demonstrated with morphological description and effects on apoptotic pathways using molecular biological techniques.
Keywords: BCCAO; ischemia; retinoprotection; urocortin 2; diazoxide; PACAP; PARP-inhibitor; rat retina
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MDPI and ACS Style

Szabadfi, K.; Mester, L.; Reglodi, D.; Kiss, P.; Babai, N.; Racz, B.; Kovacs, K.; Szabo, A.; Tamas, A.; Gabriel, R.; Atlasz, T. Novel Neuroprotective Strategies in Ischemic Retinal Lesions. Int. J. Mol. Sci. 2010, 11, 544-561.

AMA Style

Szabadfi K, Mester L, Reglodi D, Kiss P, Babai N, Racz B, Kovacs K, Szabo A, Tamas A, Gabriel R, Atlasz T. Novel Neuroprotective Strategies in Ischemic Retinal Lesions. International Journal of Molecular Sciences. 2010; 11(2):544-561.

Chicago/Turabian Style

Szabadfi, Krisztina; Mester, Laszlo; Reglodi, Dora; Kiss, Peter; Babai, Norbert; Racz, Boglarka; Kovacs, Krisztina; Szabo, Aliz; Tamas, Andrea; Gabriel, Robert; Atlasz, Tamas. 2010. "Novel Neuroprotective Strategies in Ischemic Retinal Lesions." Int. J. Mol. Sci. 11, no. 2: 544-561.

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