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• Bock, E
• Berezin, V
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• Bock, E
• Berezin, V
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• Bock, E
• Berezin, V

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Int. J. Mol. Sci. 2010, 11(6), 2291-2305; doi:10.3390/ijms11062291

Article

Neuritogenic and Neuroprotective Properties of Peptide Agonists of the Fibroblast Growth Factor Receptor

Shizhong Li, Elisabeth Bock and Vladimir Berezin*

Protein Laboratory, Department of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen, Copenhagen N, Denmark

* Author to whom correspondence should be addressed.

Received: 16 April 2010 / Accepted: 21 May 2010 / Published: 26 May 2010

(This article belongs to the Special Issue Neuroprotective Strategies)

Download PDF Full-Text [323 KB, uploaded 26 May 2010 16:20 CEST]

Abstract: Fibroblast growth factor receptors (FGFRs) interact with their cognate ligands, FGFs, and with a number of cell adhesion molecules (CAMs), such as the neural cell adhesion molecule (NCAM), mediating a wide range of events during the development and maintenance of the nervous system. Determination of protein structure, in silico modeling and biological studies have recently resulted in the identification of FGFR binding peptides derived from various FGFs and NCAM mimicking the effects of these molecules with regard to their neuritogenic and neuroprotective properties. This review focuses on recently developed functional peptide agonists of FGFR with possible therapeutic potential.

Keywords: FGF; FGFR; NCAM; FGFR agonist; neuroprotective effect

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