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Int. J. Mol. Sci. 2010, 11(1), 140-153; doi:10.3390/ijms11010140
Article

Neuroprotective Effects of Ischemic Preconditioning on Global Brain Ischemia through Up-Regulation of Acid-Sensing Ion Channel 2a

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Received: 13 November 2009; in revised form: 4 January 2010 / Accepted: 7 January 2010 / Published: 12 January 2010
(This article belongs to the Special Issue Neuroprotective Strategies)
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Abstract: Transient forebrain or global ischemia induces cell death in vulnerable CA1 pyramidal neurons. A brief period of ischemia, i.e., ischemic preconditioning, affords CA1 neurons robust protection against a subsequent, more prolonged ischemic challenge. Using the four-vessel occlusion model, we established an ischemic preconditioning model in which rodents were subjected to 3 min of sublethal ischemia 48 h before a 15 min lethal ischemia. We showed that preconditioning attenuated the ischemia-induced neural cell death and DNA fragmentation in the hippocampal CA1 region. RT-PCR and western blot analysis showed that preconditioning prior to an ischemic insult significantly increased ASIC 2a mRNA and protein expression in comparison to the ischemic insult alone (p < 0.01). These findings implicate a new role of ASIC 2a on endogenous neuroprotection from ischemic insult.
Keywords: acid-sensing ion channel 2a; ischemic preconditioning; global brain ischemia; neuroprotection acid-sensing ion channel 2a; ischemic preconditioning; global brain ischemia; neuroprotection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Miao, Y.; Zhang, W.; Lin, Y.; Lu, X.; Qiu, Y. Neuroprotective Effects of Ischemic Preconditioning on Global Brain Ischemia through Up-Regulation of Acid-Sensing Ion Channel 2a. Int. J. Mol. Sci. 2010, 11, 140-153.

AMA Style

Miao Y, Zhang W, Lin Y, Lu X, Qiu Y. Neuroprotective Effects of Ischemic Preconditioning on Global Brain Ischemia through Up-Regulation of Acid-Sensing Ion Channel 2a. International Journal of Molecular Sciences. 2010; 11(1):140-153.

Chicago/Turabian Style

Miao, Yifeng; Zhang, Weiqiao; Lin, Yuchang; Lu, Xiaojie; Qiu, Yongming. 2010. "Neuroprotective Effects of Ischemic Preconditioning on Global Brain Ischemia through Up-Regulation of Acid-Sensing Ion Channel 2a." Int. J. Mol. Sci. 11, no. 1: 140-153.


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