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Int. J. Mol. Sci. 2010, 11(1), 140-153; doi:10.3390/ijms11010140

Neuroprotective Effects of Ischemic Preconditioning on Global Brain Ischemia through Up-Regulation of Acid-Sensing Ion Channel 2a

1
Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
2
Nanjing Medical University, Affiliated Wuxi No. 2 Hospital, Neuroscience Center, Wuxi, China
*
Authors to whom correspondence should be addressed.
Received: 13 November 2009 / Revised: 4 January 2010 / Accepted: 7 January 2010 / Published: 12 January 2010
(This article belongs to the Special Issue Neuroprotective Strategies (special issue))
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Abstract

Transient forebrain or global ischemia induces cell death in vulnerable CA1 pyramidal neurons. A brief period of ischemia, i.e., ischemic preconditioning, affords CA1 neurons robust protection against a subsequent, more prolonged ischemic challenge. Using the four-vessel occlusion model, we established an ischemic preconditioning model in which rodents were subjected to 3 min of sublethal ischemia 48 h before a 15 min lethal ischemia. We showed that preconditioning attenuated the ischemia-induced neural cell death and DNA fragmentation in the hippocampal CA1 region. RT-PCR and western blot analysis showed that preconditioning prior to an ischemic insult significantly increased ASIC 2a mRNA and protein expression in comparison to the ischemic insult alone (p < 0.01). These findings implicate a new role of ASIC 2a on endogenous neuroprotection from ischemic insult.
Keywords: acid-sensing ion channel 2a; ischemic preconditioning; global brain ischemia; neuroprotection acid-sensing ion channel 2a; ischemic preconditioning; global brain ischemia; neuroprotection
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Miao, Y.; Zhang, W.; Lin, Y.; Lu, X.; Qiu, Y. Neuroprotective Effects of Ischemic Preconditioning on Global Brain Ischemia through Up-Regulation of Acid-Sensing Ion Channel 2a. Int. J. Mol. Sci. 2010, 11, 140-153.

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