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Human Umbilical Cord Blood Stem Cells: Rational for Use as a Neuroprotectant in Ischemic Brain Disease
The School of Pharmacy Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
Division of Hematology and Cord Blood Bank, Chaim Sheba Medical Center, Tel-Hashomer, Israel
* Author to whom correspondence should be addressed.
Received: 18 August 2010; in revised form: 15 September 2010 / Accepted: 15 September 2010 / Published: 21 September 2010
Abstract: The use of stem cells for reparative medicine was first proposed more than three decades ago. Hematopoietic stem cells from bone marrow, peripheral blood and human umbilical cord blood (CB) have gained major use for treatment of hematological indications. CB, however, is also a source of cells capable of differentiating into various non-hematopoietic cell types, including neural cells. Several animal model reports have shown that CB cells may be used for treatment of neurological injuries. This review summarizes the information available on the origin of CB-derived neuronal cells and the mechanisms proposed to explain their action. The potential use of stem/progenitor cells for treatment of ischemic brain injuries is discussed. Issues that remain to be resolved at the present stage of preclinical trials are addressed.
Keywords: human umbilical cord blood stem cells; brain ischemia; neuroprotection
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Arien-Zakay, H.; Lecht, S.; Nagler, A.; Lazarovici, P. Human Umbilical Cord Blood Stem Cells: Rational for Use as a Neuroprotectant in Ischemic Brain Disease. Int. J. Mol. Sci. 2010, 11, 3513-3528.
Arien-Zakay H, Lecht S, Nagler A, Lazarovici P. Human Umbilical Cord Blood Stem Cells: Rational for Use as a Neuroprotectant in Ischemic Brain Disease. International Journal of Molecular Sciences. 2010; 11(9):3513-3528.
Arien-Zakay, Hadar; Lecht, Shimon; Nagler, Arnon; Lazarovici, Philip. 2010. "Human Umbilical Cord Blood Stem Cells: Rational for Use as a Neuroprotectant in Ischemic Brain Disease." Int. J. Mol. Sci. 11, no. 9: 3513-3528.