Int. J. Mol. Sci. 2010, 11(9), 3513-3528; doi:10.3390/ijms11093513
Review

Human Umbilical Cord Blood Stem Cells: Rational for Use as a Neuroprotectant in Ischemic Brain Disease

Hadar Arien-Zakay 1,2 email, Shimon Lecht 1 email, Arnon Nagler 2 email and Philip Lazarovici 1,* email
1 The School of Pharmacy Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel 2 Division of Hematology and Cord Blood Bank, Chaim Sheba Medical Center, Tel-Hashomer, Israel
* Author to whom correspondence should be addressed.
Received: 18 August 2010; in revised form: 15 September 2010 / Accepted: 15 September 2010 / Published: 21 September 2010
(This article belongs to the Special Issue Neuroprotective Strategies)
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Abstract: The use of stem cells for reparative medicine was first proposed more than three decades ago. Hematopoietic stem cells from bone marrow, peripheral blood and human umbilical cord blood (CB) have gained major use for treatment of hematological indications. CB, however, is also a source of cells capable of differentiating into various non-hematopoietic cell types, including neural cells. Several animal model reports have shown that CB cells may be used for treatment of neurological injuries. This review summarizes the information available on the origin of CB-derived neuronal cells and the mechanisms proposed to explain their action. The potential use of stem/progenitor cells for treatment of ischemic brain injuries is discussed. Issues that remain to be resolved at the present stage of preclinical trials are addressed.
Keywords: human umbilical cord blood stem cells; brain ischemia; neuroprotection

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MDPI and ACS Style

Arien-Zakay, H.; Lecht, S.; Nagler, A.; Lazarovici, P. Human Umbilical Cord Blood Stem Cells: Rational for Use as a Neuroprotectant in Ischemic Brain Disease. Int. J. Mol. Sci. 2010, 11, 3513-3528.

AMA Style

Arien-Zakay H, Lecht S, Nagler A, Lazarovici P. Human Umbilical Cord Blood Stem Cells: Rational for Use as a Neuroprotectant in Ischemic Brain Disease. International Journal of Molecular Sciences. 2010; 11(9):3513-3528.

Chicago/Turabian Style

Arien-Zakay, Hadar; Lecht, Shimon; Nagler, Arnon; Lazarovici, Philip. 2010. "Human Umbilical Cord Blood Stem Cells: Rational for Use as a Neuroprotectant in Ischemic Brain Disease." Int. J. Mol. Sci. 11, no. 9: 3513-3528.

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