Table of Contents
Mar. Drugs, Volume 15, Issue 12 (December 2017)
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Cover Story (view full-size image) Shown on the cover is a photograph of a bloom of Microcystis sp. in a water reservoir and a [...] Read more. Shown on the cover is a photograph of a bloom of Microcystis sp. in a water reservoir and a close-up of the bloom material with a handful of biologically active metabolites which are produced by cyanobacteria in such blooms. Worldwide studies on the chemistry and toxicology of Microcystis and other cyanobacteria water-blooms, over the last forty-five years, resulted in the discovery of several groups of toxins, of which the microcystins-group is the most abundant and divers with over hundred members. The five groups of protease inhibitors that accompany the microcystins; micropeptins, aeruginosins, anabaenopeptins, microginins and microviridins, sum to more then three hundred and fifty structures. Some other hundred compounds, mainly cyclic peptides, were also described from fresh water cyanobacteria. The stimuli for the biosynthesis of these libraries of compounds is yet hardly understood. View this paper