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Special Issue "Compounds from Cyanobacteria II, 2017"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 1 December 2017

Special Issue Editor

Guest Editor
Assoc. Prof. Michele R. Prinsep

Department of Chemistry, The University of Waikato, Private Bag 3105, Hamilton 3240, New Zealand
Website | E-Mail
Interests: natural products chemistry; application of spectral methods to structural determination; biologically active compounds and structure-activity relationships; chemical ecology

Special Issue Information

Dear Colleagues,

Cyanobacteria (blue-green algae) are an ancient and successful group of organisms that are found in a wide range of marine and freshwater habitats and in conditions as extreme as the heat of volcanic regions to the colds of Antarctica. They have proven to be an excellent source of secondary metabolites, many of which possess biological activity. The most common class of compounds found in cyanobacteria are oligopeptides (predominantly cyclic peptides). These are synthesised by nonribosomal peptide synthetases and many contain unique or unusual amino acids. Some of the other compound classes that have been isolated from cyanobacteria include terpenes and alkaloids.

Many of the natural products produced by cyanobacteria may be ecologically significant and some of the toxic metabolites are a human health concern, especially when present in recreational water bodies or fisheries. Cyanobacteria often have the means to produce many more metabolites than are actually expressed, so an understanding of biosynthesis and genetics in these organisms is vitally important.

There is considerable overlap between metabolites produced by terrestrial and marine cyanobacteria, hence the scope of this Special Issue has been widened to include compounds from freshwater cyanobacteria, in addition to studies of marine species. However, manuscripts describing studies of freshwater cyanobacteria with no obvious relevance to marine species will not be considered.

Assoc. Prof. Michele R. Prinsep
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cyanobacteria
  • blue-green algae
  • algal bloom
  • oligopeptides
  • amino acids
  • non-ribosomal peptide synthesis
  • biological activity
  • biosynthesis
  • secondary metabolites
  • toxins

Published Papers (1 paper)

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Research

Open AccessArticle Tricholides A and B and Unnarmicin D: New Hybrid PKS-NRPS Macrocycles Isolated from an Environmental Collection of Trichodesmium thiebautii
Mar. Drugs 2017, 15(7), 206; doi:10.3390/md15070206
Received: 10 May 2017 / Revised: 10 June 2017 / Accepted: 27 June 2017 / Published: 30 June 2017
Cited by 1 | PDF Full-text (828 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Bioassay-guided isolation of the lipophilic extract of Trichodesmium thiebautii bloom material led to the purification and structure characterization of two new hybrid polyketide-non-ribosomal peptide (PKS-NRPS) macrocyclic compounds, tricholides A and B (1 and 2). A third macrocyclic compound, unnarmicin D (
[...] Read more.
Bioassay-guided isolation of the lipophilic extract of Trichodesmium thiebautii bloom material led to the purification and structure characterization of two new hybrid polyketide-non-ribosomal peptide (PKS-NRPS) macrocyclic compounds, tricholides A and B (1 and 2). A third macrocyclic compound, unnarmicin D (3), was identified as a new depsipeptide in the unnarmicin family, given its structural similarity to the existing compounds in this group. The planar structures of 13 were determined using 1D and 2D NMR spectra and complementary spectroscopic and spectrometric procedures. The absolute configurations of the amino acid components of 13 were determined via acid hydrolysis, derivitization with Marfey’s reagent and HPLC-UV comparison to authentic amino acid standards. The absolute configuration of the 3-hydroxydodecanoic acid moiety in 3 was determined using a modified Mosher’s esterification procedure on a linear derivative of tricharmicin (4) and additionally by a comparison of 13C NMR shifts of 3 to known depsipeptides with β-hydroxy acid subunits. Tricholide B (2) showed moderate cytotoxicity to Neuro-2A murine neuroblastoma cells (EC50: 14.5 ± 6.2 μM). Full article
(This article belongs to the Special Issue Compounds from Cyanobacteria II, 2017)
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