Table of Contents
Mar. Drugs, Volume 16, Issue 1 (January 2018)
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Cover Story (view full-size image) Aaptos is a genus of marine sponge which belongs to Suberitidae and distributed in the tropical and [...] Read more. Aaptos is a genus of marine sponge which belongs to Suberitidae and distributed in the tropical and subtropical oceans. Aaptamine, demethyloxyaaptamine, and isoaaptamine were isolated from Aaptos sp. methanolic extract. In this study, we sought to elucidate the cytotoxic activity of aaptamine alkaloids in vitro along with their mechanism of action. The effect of IAp treatment on ROS generation and ER stress-related proteins in breast T-47D cancer cells was evaluated showing an enhancement in ROS generation as well as IRE 1α and Bip expression. Based on the results that ROS and ER stress are involved in IAp effect on T-47D cells, we hypothesized that the induction of apoptosis and autophagy might be attributed to mitochondrial dysfunction-dependent apoptosis and Nrf2/p62 dependent autophagy.