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Special Issue "Development and Application of Herbal Medicine from Marine Origin"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 31 March 2018

Special Issue Editors

Guest Editor
Prof. Dr. Tsong-Long Hwang

1. Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan
2. Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
Website | E-Mail
Interests: inflammopharmacology; ınnate immunity; signal transduction; protein kinase; phytopharmacology; drug research and development
Guest Editor
Prof. Dr. Ping-Jyun Sung

1. National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
2. Graduate Institute of Marine Biology, National Dong Hwa Univesity, Pingtung 944, Taiwan
3. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
4. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
5. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Website | E-Mail
Phone: 886-8-8825037
Fax: 886-8-8825087
Interests: marine natural products; marine chemical ecology; bioactive substances from cultured marine invertebrates
Guest Editor
Assoc. Prof. Dr. Chih-Chuang Liaw

1. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan
2. Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan
3. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4. Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan
Website | E-Mail
Interests: marine microbial natural products, de-replication, symbiotic microbes, biofunctional activities

Special Issue Information

Dear Colleagues,

Marine herbal medicine generally refers to the use of marine plants as original materials to develop crude drugs, or for other medical use. The term ‘marine plants’ usually denotes macroalgae grown between intertidal and sub-intertidal zones, including Chlorophyta, Phaeophyta and Rhodophyta. Considerable progress has been made in the field of biomedical research into marine microalgae and microorganisms in the past decade. As the most important source of fundamental products in the world, marine plants have a very important role in biomedical research. Furthermore, worldwide studies have consistently demonstrated that many crude drugs derived from marine plants contain novel ingredients that may benefit health or can be used in the treatment of diseases; some have been developed into health foods, and some even into drugs. It is expected that there are many substances of marine plant origin that will have medical applications in terms of improving human health, and are awaiting discovery.

In this Special Issue, Development and Application of Herbal Medicine of Marine Origin, we will provide a platform for researchers to publish biomedical studies on substances of marine plant origin. We welcome submissions from scientists and academics from across the world.

Prof. Dr. Tsong-Long Hwang
Prof. Dr. Ping-Jyun Sung
Assoc. Prof. Dr. Chih-Chuang Liaw
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Herbal medicine
  • Algae
  • Microorganism
  • Biomedicine
  • Disease
  • Drug

Published Papers (4 papers)

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Research

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Open AccessArticle Angiotensin I-Converting Enzyme (ACE) Inhibitory Activity, Antioxidant Properties, Phenolic Content and Amino Acid Profiles of Fucus spiralis L. Protein Hydrolysate Fractions
Mar. Drugs 2017, 15(10), 311; doi:10.3390/md15100311
Received: 2 September 2017 / Revised: 29 September 2017 / Accepted: 9 October 2017 / Published: 13 October 2017
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Abstract
Food protein-derived hydrolysates with multi-bioactivities such as antihypertensive and antioxidant properties have recently received special attention since both activities can play significant roles in preventing cardiovascular diseases. This study reports, for the first time, the angiotensin I-converting enzyme (ACE)-inhibition and antioxidant properties of
[...] Read more.
Food protein-derived hydrolysates with multi-bioactivities such as antihypertensive and antioxidant properties have recently received special attention since both activities can play significant roles in preventing cardiovascular diseases. This study reports, for the first time, the angiotensin I-converting enzyme (ACE)-inhibition and antioxidant properties of ultrafiltrate fractions (UF) with different molecular weight ranges (<1, 1–3 and ≥3 kDa) obtained from Fucus spiralis protein hydrolysate (FSPH) digested with cellulase–bromelain. The amino acids profile, recovery yield, protein, peptide and total phenolic contents of these FSPH-UF, and the in vitro digestibility of F. spiralis crude protein were also investigated. FSPH-UF ≥3 kDa presented remarkably higher ACE-inhibition, yield, peptide and polyphenolic (phlorotannins) contents. Antioxidant analysis showed that FSPH-UF <1 kDa and ≥3 kDa exhibited significantly higher scavenging of 2,2-diphenyl-1-picrylhydrazyl radical and ferrous ion-chelating (FIC) activity. FSPH-UF ≥3 kDa had also notably higher ferric reducing antioxidant power (FRAP). Strong correlations were observed between ACE-inhibition and antioxidant activities (FIC and FRAP). The results suggest that ACE-inhibition and antioxidant properties of FSPH-UF may be due to the bioactive peptides and polyphenols released during the enzymatic hydrolysis. In conclusion, this study shows the potential use of defined size FSPH-UF for the prevention/treatment of hypertension and/or oxidative stress-related diseases. Full article
(This article belongs to the Special Issue Development and Application of Herbal Medicine from Marine Origin)
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Open AccessArticle Pharmacokinetics of Jaspine B and Enhancement of Intestinal Absorption of Jaspine B in the Presence of Bile Acid in Rats
Mar. Drugs 2017, 15(9), 279; doi:10.3390/md15090279
Received: 13 July 2017 / Revised: 13 August 2017 / Accepted: 30 August 2017 / Published: 1 September 2017
Cited by 1 | PDF Full-text (1981 KB) | HTML Full-text | XML Full-text
Abstract
We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal absorption, distribution, metabolism, and excretion of Jaspine B in rats. The oral bioavailability of Jaspine B was 6.2%, but it decreased to 1.6% in bile-depleted rats and increased to 41.2%
[...] Read more.
We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal absorption, distribution, metabolism, and excretion of Jaspine B in rats. The oral bioavailability of Jaspine B was 6.2%, but it decreased to 1.6% in bile-depleted rats and increased to 41.2% (normal) and 23.5% (bile-depleted) with taurocholate supplementation (60 mg/kg). Consistent with the increased absorption in the presence of bile salts, rat intestinal permeability of Jaspine B also increased in the presence of 10 mM taurocholate or 20% bile. Further studies demonstrated that the enhanced intestinal permeability with bile salts was due to increased lipophilicity and decreased membrane integrity. Jaspine B was designated as a highly tissue-distributed compound, because it showed large tissue to plasma ratios in the brain, kidney, heart, and spleen. Moreover, the recovery of Jaspine B from the feces and urine after an intravenous administration was about 6.3%, suggesting a substantial metabolism of Jaspine B. Consistent with this observation, 80% of the administered Jaspine B was degraded after 1 h incubation with rat liver microsomes. In conclusion, the facilitated intestinal permeability in the presence of bile salts could significantly increase the bioavailability of Jaspine B and could lead to the development of oral formulations of Jaspine B with bile salts. Moreover, the highly distributed features of Jaspine B in the brain, kidney, heart, and spleen should be carefully considered in the therapeutic effect and toxicity of this compound. Full article
(This article belongs to the Special Issue Development and Application of Herbal Medicine from Marine Origin)
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Open AccessArticle Inhibitory Growth of Oral Squamous Cell Carcinoma Cancer via Bacterial Prodigiosin
Mar. Drugs 2017, 15(7), 224; doi:10.3390/md15070224
Received: 11 May 2017 / Revised: 2 July 2017 / Accepted: 13 July 2017 / Published: 15 July 2017
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Abstract
Chemotherapy drugs for oral cancers always cause side effects and adverse effects. Currently natural sources and herbs are being searched for treated human oral squamous carcinoma cells (OSCC) in an effort to alleviate the causations of agents in oral cancers chemotherapy. This study
[...] Read more.
Chemotherapy drugs for oral cancers always cause side effects and adverse effects. Currently natural sources and herbs are being searched for treated human oral squamous carcinoma cells (OSCC) in an effort to alleviate the causations of agents in oral cancers chemotherapy. This study investigates the effect of prodigiosin (PG), an alkaloid and natural red pigment as a secondary metabolite of Serratia marcescens, to inhibit human oral squamous carcinoma cell growth; thereby, developing a new drug for the treatment of oral cancer. In vitro cultured human OSCC models (OECM1 and SAS cell lines) were used to test the inhibitory growth of PG via cell cytotoxic effects (MTT assay), cell cycle analysis, and Western blotting. PG under various concentrations and time courses were shown to effectively cause cell death and cell-cycle arrest in OECM1 and SAS cells. Additionally, PG induced autophagic cell death in OECM1 and SAS cells by LC3-mediated P62/LC3-I/LC3-II pathway at the in vitro level. These findings elucidate the role of PG, which may target the autophagic cell death pathways as a potential agent in cancer therapeutics. Full article
(This article belongs to the Special Issue Development and Application of Herbal Medicine from Marine Origin)
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Review

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Open AccessReview Terpenoids from Octocorals of the Genus Pachyclavularia
Mar. Drugs 2017, 15(12), 382; doi:10.3390/md15120382
Received: 2 November 2017 / Revised: 1 December 2017 / Accepted: 4 December 2017 / Published: 5 December 2017
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Abstract
In this paper, we reviewed natural compounds isolated from octocorals belonging to the genus Pachyclavularia, including 20 cembrane-, 39 briarane-, and eight briarellin-related diterpenoids, and one secosterol. The chemical constituents of these 68 secondary metabolites, and their names, structures, and bioactivities, along
[...] Read more.
In this paper, we reviewed natural compounds isolated from octocorals belonging to the genus Pachyclavularia, including 20 cembrane-, 39 briarane-, and eight briarellin-related diterpenoids, and one secosterol. The chemical constituents of these 68 secondary metabolites, and their names, structures, and bioactivities, along with studies of their biological activities, are summarized in this review. Based on the literature, many of these compounds possess bioactivities, including anti-inflammation properties, cytotoxicity, and ichthyotoxicity, suggesting that they may have the potential to be developed into biomedical agents for treatment. Full article
(This article belongs to the Special Issue Development and Application of Herbal Medicine from Marine Origin)
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