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Special Issue "Natural Products from Coral Reef Organisms"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 31 December 2017

Special Issue Editor

Guest Editor
Prof. Jyh-Horng Sheu

Department of Marine Biotechnology and Resources, Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
E-Mail
Interests: marine organisms; natural products; organic reactions; structure elucidation

Special Issue Information

Dear Colleagues,                

Coral reefs are the major habitat of numerous marine organisms. Ecologically, they are referred to as the rainforests of ocean, and are home to many species of algae, cyanobacteria, and marine animals, such as fish, crustaceans, corals, sponges, bryozoans, tunicates, mollusks, and echinoderms. Many reef organisms, and the associated microorganisms, can, not only produce nutritional substances, but also bioactive metabolites to defend themselves against predators, fight diseases, and prevent the fouling and overgrowth of other organisms. These natural products may also be useful for the discovery of new drugs. Dozens of promising compounds, originating from coral reef organisms, have been approved or are under clinical trials for use as painkillers, anticancer purposes, and antiviral drugs, or for the treatment of other diseases. Thus, coral reef organisms are well recognized as a rich source of bioactive natural products, which might become useful medicines in future drug development.

The goal of this Special Issue is to provide a platform for scientists of related fields to share and report the discovery and development of natural products from coral reef organisms. We invite researchers from all over the world to publish original research and review articles in this Special Issue. Potential topics include, but are not limited to:

  • Natural products from marine algae and microalgae
  • Natural products from marine invertebrates
  • Natural products from marine microorganisms
  • Marine natural products as antifouling agents
  • Marine natural products for fighting diseases

Prof. Jyh-Horng Sheu
Email: sheu@mail.nsysu.edu.tw
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Coral reef organism
  • Natural product
  • Structure elucidation
  • Drug development

Published Papers (6 papers)

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Research

Open AccessArticle Anti-Inflammatory Lobane and Prenyleudesmane Diterpenoids from the Soft Coral Lobophytum varium
Mar. Drugs 2017, 15(10), 300; doi:10.3390/md15100300
Received: 29 August 2017 / Revised: 22 September 2017 / Accepted: 27 September 2017 / Published: 29 September 2017
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Abstract
New lobane-based diterpenoids lobovarols A–D (14) and a prenyleudesmane-type diterpenoid lobovarol E (5) along with seven known related diterpenoids (612) were isolated from the ethyl acetate extract of a Taiwanese soft coral Lobophytum
[...] Read more.
New lobane-based diterpenoids lobovarols A–D (14) and a prenyleudesmane-type diterpenoid lobovarol E (5) along with seven known related diterpenoids (612) were isolated from the ethyl acetate extract of a Taiwanese soft coral Lobophytum varium. Their structures were identified on the basis of multiple spectroscopic analyses and spectral comparison. The absolute configuration at C-16 of the known compound 11 is reported herein for the first time. The anti-inflammatory activities of compounds 112 were assessed by measuring their inhibitory effect on N-formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release in human neutrophils. Metabolites 2, 5, and 11 were found to show moderate inhibitory activity on the generation of superoxide anion, while compounds 5, 8, 11, and 12 could effectively suppress elastase release in fMLP/CB-stimulated human neutrophil cells at 10 μM. All of the isolated diterpenoids did not exhibit cytotoxic activity (IC50 > 50 μM) towards a limited panel of cancer cell lines. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank
Mar. Drugs 2017, 15(9), 280; doi:10.3390/md15090280
Received: 11 August 2017 / Revised: 29 August 2017 / Accepted: 30 August 2017 / Published: 1 September 2017
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Abstract
A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular, 1
[...] Read more.
A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular, 1 possesses a β-D-xylopyranose. The structures of the new compounds were elucidated on the basis of spectroscopic analyses. The cytotoxicities of compounds 1–4 against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of these new compounds 1–4 were also evaluated by measuring their ability to suppress superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils. Compounds 2 and 3 were shown to exhibit significant cytotoxicity, and compounds 3 and 4 were also found to display attracting anti-inflammatory activities. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Sinulariolide Suppresses Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase through the PI3K/AKT/mTOR Signaling Pathway in Human Bladder Cancer Cells
Mar. Drugs 2017, 15(8), 238; doi:10.3390/md15080238
Received: 17 April 2017 / Revised: 26 July 2017 / Accepted: 26 July 2017 / Published: 2 August 2017
Cited by 1 | PDF Full-text (6121 KB) | HTML Full-text | XML Full-text
Abstract
Sinulariolide is a natural product extracted from the cultured-type soft coral Sinularia flexibilis, and possesses bioactivity against the movement of several types of cancer cells. However, the molecular pathway behind its effects on human bladder cancer remain poorly understood. Using a human
[...] Read more.
Sinulariolide is a natural product extracted from the cultured-type soft coral Sinularia flexibilis, and possesses bioactivity against the movement of several types of cancer cells. However, the molecular pathway behind its effects on human bladder cancer remain poorly understood. Using a human bladder cancer cell line as an in vitro model, this study investigated the underlying mechanism of sinulariolide against cell migration/invasion in TSGH-8301 cells. We found that sinulariolide inhibited TSGH-8301 cell migration/invasion, and the effect was concentration-dependent. Furthermore, the protein expressions of matrix metalloproteinases (MMPs) MMP-2 and MMP-9, as well as urokinase, were significantly decreased after 24-h sinulariolide treatment. Meanwhile, the increased expression of tissue inhibitors of metalloproteinases (TIMPs) TIMP-1 and TIMP-2 were in parallel with an increased concentration of sinulariolide. Finally, the expressions of several key phosphorylated proteins in the mTOR signaling pathway were also downregulated by sinulariolide treatment. Our results demonstrated that sinulariolide has significant effects against TSGH-8301 cell migration/invasion, and its effects were associated with decreased levels of MMP-2/-9 and urokinase expression, as well as increased TIMP-1/TIMP-2 expression. The inhibitory effects were mediated by reducing phosphorylation proteins of the PI3K, AKT, and mTOR signaling pathway. The findings suggested that sinulariolide is a good candidate for advanced investigation with the aim of developing a new drug for the treatment of human bladder cancer. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Sterols from the Octocoral Nephthea columnaris
Mar. Drugs 2017, 15(7), 212; doi:10.3390/md15070212
Received: 23 May 2017 / Revised: 26 June 2017 / Accepted: 1 July 2017 / Published: 4 July 2017
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Abstract
Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2
[...] Read more.
Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2 were elucidated by using spectroscopic methods and comparing the spectroscopic data with those of known related metabolites. Sterol 3 was found to suppress superoxide anion production and elastase secretion by human neutrophils. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle 24-Methyl-Cholesta-5,24(28)-Diene-3β,19-diol-7β-Monoacetate Inhibits Human Small Cell Lung Cancer Growth In Vitro and In Vivo via Apoptosis Induction
Mar. Drugs 2017, 15(7), 210; doi:10.3390/md15070210
Received: 19 April 2017 / Revised: 13 June 2017 / Accepted: 26 June 2017 / Published: 1 July 2017
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Abstract
24-methyl-cholesta-5,24(28)-diene-3β,19-diol-7β-monoacetate (MeCDDA) is a natural steroid compound isolated from a wild-type soft coral (Nephthea erecta). The present study aimed to investigate the anti-small cell lung cancer (SCLC) effects of MeCDDA in vitro and in vivo, as well as to elucidate its
[...] Read more.
24-methyl-cholesta-5,24(28)-diene-3β,19-diol-7β-monoacetate (MeCDDA) is a natural steroid compound isolated from a wild-type soft coral (Nephthea erecta). The present study aimed to investigate the anti-small cell lung cancer (SCLC) effects of MeCDDA in vitro and in vivo, as well as to elucidate its underlying mechanism. Our results indicated that H1688 and H146 cells show relevant sensitivity to MeCDDA, and the exposure to MeCDDA in SCLC cells caused dose-dependent growth inhibitory responses. In addition, MeCDDA treatment promoted cell apoptosis and increased the activities of caspases in H1688 cells, reducing the mitochondrial membrane potential and stimulating the release of cytochrome c into the cytosol. Along with the increase in Bax expression and reduction in Bcl-2, the MeCDDA treatment also significantly decreased Akt and mTOR phosphorylation. Finally, MeCDDA treatment in the mouse xenograft model of H1688 cells exhibited significant inhibition of tumor growth, corroborating MeCDDA as a potential pre-clinical candidate for the treatment of SCLC. Overall, our results demonstrate that the cytotoxic effects of MeCDDA towards H1688 and H146 cells, possibly through the activation of the mitochondrial apoptotic pathway and inhibition of the PI3K/Akt/mTOR pathway, merit further studies for its possible clinical application in chemotherapy. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Isoprenoids from the Soft Coral Sarcophyton glaucum
Mar. Drugs 2017, 15(7), 202; doi:10.3390/md15070202
Received: 6 June 2017 / Revised: 16 June 2017 / Accepted: 22 June 2017 / Published: 27 June 2017
Cited by 1 | PDF Full-text (2119 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Five new isoprenoids, 3,4,8,16-tetra-epi-lobocrasol (1), 1,15β-epoxy-deoxysarcophine (2), 3,4-dihydro-4α,7β,8α-trihydroxy-Δ2-sarcophine (3), ent-sarcophyolide E (4), and 16-deacetyl- halicrasterol B (5) and ten known compounds 6‒15, were characterized from the marine soft coral Sarcophyton glaucum,
[...] Read more.
Five new isoprenoids, 3,4,8,16-tetra-epi-lobocrasol (1), 1,15β-epoxy-deoxysarcophine (2), 3,4-dihydro-4α,7β,8α-trihydroxy-Δ2-sarcophine (3), ent-sarcophyolide E (4), and 16-deacetyl- halicrasterol B (5) and ten known compounds 6‒15, were characterized from the marine soft coral Sarcophyton glaucum, collected off Taitung coastline. Their structures were defined by analyzing spectra data, especially 2D NMR and electronic circular dichroism (ECD). The structure of the known compound lobocrasol (7) was revised. Cytotoxicity potential of the isolated compounds was reported, too. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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