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Special Issue "Natural Products from Coral Reef Organisms"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 December 2017)

Special Issue Editor

Guest Editor
Prof. Jyh-Horng Sheu

Department of Marine Biotechnology and Resources, Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
E-Mail
Interests: marine organisms; natural products; organic reactions; structure elucidation

Special Issue Information

Dear Colleagues,                

Coral reefs are the major habitat of numerous marine organisms. Ecologically, they are referred to as the rainforests of ocean, and are home to many species of algae, cyanobacteria, and marine animals, such as fish, crustaceans, corals, sponges, bryozoans, tunicates, mollusks, and echinoderms. Many reef organisms, and the associated microorganisms, can, not only produce nutritional substances, but also bioactive metabolites to defend themselves against predators, fight diseases, and prevent the fouling and overgrowth of other organisms. These natural products may also be useful for the discovery of new drugs. Dozens of promising compounds, originating from coral reef organisms, have been approved or are under clinical trials for use as painkillers, anticancer purposes, and antiviral drugs, or for the treatment of other diseases. Thus, coral reef organisms are well recognized as a rich source of bioactive natural products, which might become useful medicines in future drug development.

The goal of this Special Issue is to provide a platform for scientists of related fields to share and report the discovery and development of natural products from coral reef organisms. We invite researchers from all over the world to publish original research and review articles in this Special Issue. Potential topics include, but are not limited to:

  • Natural products from marine algae and microalgae

  • Natural products from marine invertebrates

  • Natural products from marine microorganisms

  • Marine natural products as antifouling agents

  • Marine natural products for fighting diseases

Prof. Jyh-Horng Sheu
Email: sheu@mail.nsysu.edu.tw
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Coral reef organism

  • Natural product

  • Structure elucidation

  • Drug development

Published Papers (14 papers)

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Research

Open AccessArticle Further New Diterpenoids as PTP1B Inhibitors from the Xisha Soft Coral Sinularia polydactyla
Mar. Drugs 2018, 16(4), 103; https://doi.org/10.3390/md16040103
Received: 11 January 2018 / Revised: 16 March 2018 / Accepted: 23 March 2018 / Published: 25 March 2018
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Abstract
A new prenyleudesmane type diterpene, sinupol (8), and a new capnosane type diterpenoid, sinulacetate (9), were isolated from the Xisha soft coral Sinularia polydactyla along with five known related diterpenes (47 and 10). Their structures,
[...] Read more.
A new prenyleudesmane type diterpene, sinupol (8), and a new capnosane type diterpenoid, sinulacetate (9), were isolated from the Xisha soft coral Sinularia polydactyla along with five known related diterpenes (47 and 10). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis, the comparison of their NMR data with those of related compounds, and time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculations. Both new compounds (8 and 9) exhibited promising inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a potential drug target for the treatment of type II diabetes and obesity. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Anti-Inflammatory Polyoxygenated Steroids from the Soft Coral Lobophytum michaelae
Mar. Drugs 2018, 16(3), 93; https://doi.org/10.3390/md16030093
Received: 26 January 2018 / Revised: 8 March 2018 / Accepted: 9 March 2018 / Published: 13 March 2018
PDF Full-text (2045 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Three new polyoxygenated steroids, michosterols A–C (13), and four known compounds (47) were isolated from the ethyl acetate (EtOAc) extract of the soft coral Lobophytum michaelae, collected off the coast of Taitung. The structures
[...] Read more.
Three new polyoxygenated steroids, michosterols A–C (13), and four known compounds (47) were isolated from the ethyl acetate (EtOAc) extract of the soft coral Lobophytum michaelae, collected off the coast of Taitung. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and comparison of the nuclear magnetic resonance (NMR) data with related steroids. The cytotoxicity of compounds 13 against the proliferation of a limited panel of cancer cell lines was assayed. Compound 1 was found to display moderate cytotoxicity against adenocarcinomic human alveolar basal epithelial (A549) cancer cells. It also exhibited potent anti-inflammatory activity by suppressing superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-stimulated human neutrophils. Furthermore, 3 could effectively inhibit elastase release, as well. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Briaviolides K–N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum
Mar. Drugs 2018, 16(3), 75; https://doi.org/10.3390/md16030075
Received: 19 December 2017 / Revised: 1 February 2018 / Accepted: 23 February 2018 / Published: 27 February 2018
Cited by 1 | PDF Full-text (3491 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Four new briarane diterpenoids, briaviolides K–N (14), have been obtained from the cultured-type octocoral Briareum violaceum. Using a spectroscopic approach, the structures of briaranes 14 were identified. This study employed an in vitro model of lipopolysaccharide
[...] Read more.
Four new briarane diterpenoids, briaviolides K–N (14), have been obtained from the cultured-type octocoral Briareum violaceum. Using a spectroscopic approach, the structures of briaranes 14 were identified. This study employed an in vitro model of lipopolysaccharide (LPS)-induced inflammation in the murine macrophage RAW 264.7 cell line, and found that among the four briaranes, briarane 2 possessed anti-inflammatory activity against inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expressions in cells. In addition, principal component analysis using the chemical global positioning system (ChemGPS) for natural products (ChemGPS-NP) was employed in order to analyze the structure-activity relationship (SAR), and the results indicated that the ring conformation of the compound has a leading role in suppressing the expressions of pro-inflammatory iNOS and COX-2 proteins in macrophages. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Tetrocarcin Q, a New Spirotetronate with a Unique Glycosyl Group from a Marine-Derived Actinomycete Micromonospora carbonacea LS276
Mar. Drugs 2018, 16(2), 74; https://doi.org/10.3390/md16020074
Received: 7 December 2017 / Revised: 7 February 2018 / Accepted: 12 February 2018 / Published: 24 February 2018
Cited by 1 | PDF Full-text (2088 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
A new spirotetronate glycoside tetrocarcin Q (1) and six known analogues tetrocarcin A (2), AC6H (3), tetrocarcin N (4), tetrocarcin H (5), arisostatin A (6), and tetrocarcin F1 (7)
[...] Read more.
A new spirotetronate glycoside tetrocarcin Q (1) and six known analogues tetrocarcin A (2), AC6H (3), tetrocarcin N (4), tetrocarcin H (5), arisostatin A (6), and tetrocarcin F1 (7) were isolated from the fermentation broth of the marine-derived actinomycete Micromonospora carbonacea LS276. Their chemical structures were established on the basis of 1D- and 2D-NMR spectroscopy, as well as HR-ESI-MS analysis. The absolute configurations of their stereogenic carbons were determined by circular dichroism (CD) analysis. Compound 1 possesses 2-deoxy-allose, which is a unique sugar type at the C-9 position. This type has not been found in the previously reported spirotetronate glycosides. Compound 1 displayed moderate antibacterial activity against Bacillus subitlis ATCC 63501 with minimum inhibitory concentration (MIC) value of 12.5 μM. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa
Mar. Drugs 2018, 16(2), 47; https://doi.org/10.3390/md16020047
Received: 6 December 2017 / Revised: 9 January 2018 / Accepted: 29 January 2018 / Published: 31 January 2018
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Abstract
Three new compounds, tuberazines A–C (13), and eleven known compounds (414) were obtained from the ethanolic extract of Taiwanese zoanthid Palythoa tuberculosa. Compounds 14 are rare marine natural products with a pyrazine
[...] Read more.
Three new compounds, tuberazines A–C (13), and eleven known compounds (414) were obtained from the ethanolic extract of Taiwanese zoanthid Palythoa tuberculosa. Compounds 14 are rare marine natural products with a pyrazine moiety, and compound 5 is a tricyclic tryptamine derivative isolated from nature for the first time. The structures of all isolated metabolites were determined by analyzing their IR, Mass, NMR, and UV spectrometric data. The absolute configuration of 1 was confirmed by comparing the trend of experimental electronic circular dichroism (ECD) with calculated ECD spectra. The anti-lymphangiogenic activities of new compounds were evaluated in human lymphatic endothelial cells (LECs). Of these, new compound 3 displayed the most potent anti-lymphangiogenesis property by suppressing cell growth and tube formation of LECs. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Xeniaphyllane-Derived Terpenoids from Soft Coral Sinularia nanolobata
Mar. Drugs 2018, 16(2), 40; https://doi.org/10.3390/md16020040
Received: 28 December 2017 / Revised: 15 January 2018 / Accepted: 19 January 2018 / Published: 24 January 2018
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Abstract
A novel tetranorditerpenoid, sinubatin A (1) (having an unprecedented carbon skeleton), a new norditerpenoid, sinubatin B (2) (a 4,5-epoxycaryophyllene possessing an unusual methylfuran moiety side chain), and a known diterpenoid, gibberosin J (3) were isolated from soft
[...] Read more.
A novel tetranorditerpenoid, sinubatin A (1) (having an unprecedented carbon skeleton), a new norditerpenoid, sinubatin B (2) (a 4,5-epoxycaryophyllene possessing an unusual methylfuran moiety side chain), and a known diterpenoid, gibberosin J (3) were isolated from soft coral Sinularia nanolobata. The structures of the new compounds were elucidated by extensive analysis of spectroscopic data. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Aquaculture Soft Coral Lobophytum crassum as a Producer of Anti-Proliferative Cembranoids
Mar. Drugs 2018, 16(1), 15; https://doi.org/10.3390/md16010015
Received: 22 November 2017 / Revised: 14 December 2017 / Accepted: 19 December 2017 / Published: 7 January 2018
Cited by 1 | PDF Full-text (3991 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Our continuous search for marine bioactive secondary metabolites led to the screening of crude extracts from a variety of aquaculture soft corals. The ethyl acetate (EtOAc) extract of Lobophytum crassum showed a distinctive chemical profile that was different from the wild type. It
[...] Read more.
Our continuous search for marine bioactive secondary metabolites led to the screening of crude extracts from a variety of aquaculture soft corals. The ethyl acetate (EtOAc) extract of Lobophytum crassum showed a distinctive chemical profile that was different from the wild type. It demonstrated significant anti-proliferative activity against Molt 4 leukemia cell with an IC50 value of 1 μg/mL after 24 h. Chemical investigation focusing on the unique peaks in L. crassum profile led to the discovery of a new α-tocopherol crassumtocopherol C (1), and two new cembrane-based diterpenoids culobophylins D (2) and E (3), along with ten known cembranoids (413). The structures of these isolates were elucidated using extensive spectroscopic techniques and a comparison with previously published data of related metabolites. Compound 2 was found to possess the first identified saturated internal C4-O-C14 linkage six-membered ring among all cembrane-type diterpenoids. The anti-proliferative activity of all the isolates (except 3) was evaluated against a limited panel of leukemia cell lines (Molt 4, K562, U937, and Sup-T1). The major compounds 8 and 10 exhibited the most anti-proliferative potent effect, with IC50 values ranging from 1.2 to 7.1 μM. The Structure Activity Relationship (SAR) of the isolates suggested that the presence of lactone moieties is crucial for the anti-proliferative activity against leukemia cells. Our work indicated that the development of an efficient aquaculture protocols for soft corals led to the discovery of new secondary metabolites with unique structural features. Such protocols can lead to a sustainable supply of biologically active compounds in enough quantities for the pharmaceutical industry. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle New Cytotoxic Terpenoids from Soft Corals Nephthea chabroli and Paralemnalia thyrsoides
Mar. Drugs 2017, 15(12), 392; https://doi.org/10.3390/md15120392
Received: 4 November 2017 / Revised: 7 December 2017 / Accepted: 11 December 2017 / Published: 19 December 2017
Cited by 2 | PDF Full-text (1272 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
A novel cytotoxic diterpenoid, chabrolin A (1) (possessing an unprecedented terpenoid skeleton), as well as three new cytotoxic sesquiterpenoids, parathyrsoidins E–G (24), were isolated by cytotoxicity-guided fractionation from soft corals Nephthea chabroli and Paralemnalia thyrsoides. The
[...] Read more.
A novel cytotoxic diterpenoid, chabrolin A (1) (possessing an unprecedented terpenoid skeleton), as well as three new cytotoxic sesquiterpenoids, parathyrsoidins E–G (24), were isolated by cytotoxicity-guided fractionation from soft corals Nephthea chabroli and Paralemnalia thyrsoides. The structures of the new compounds were determined by extensive analysis of spectroscopic data. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Anti-Inflammatory Lobane and Prenyleudesmane Diterpenoids from the Soft Coral Lobophytum varium
Mar. Drugs 2017, 15(10), 300; https://doi.org/10.3390/md15100300
Received: 29 August 2017 / Revised: 22 September 2017 / Accepted: 27 September 2017 / Published: 29 September 2017
Cited by 1 | PDF Full-text (1864 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
New lobane-based diterpenoids lobovarols A–D (14) and a prenyleudesmane-type diterpenoid lobovarol E (5) along with seven known related diterpenoids (612) were isolated from the ethyl acetate extract of a Taiwanese soft coral Lobophytum
[...] Read more.
New lobane-based diterpenoids lobovarols A–D (14) and a prenyleudesmane-type diterpenoid lobovarol E (5) along with seven known related diterpenoids (612) were isolated from the ethyl acetate extract of a Taiwanese soft coral Lobophytum varium. Their structures were identified on the basis of multiple spectroscopic analyses and spectral comparison. The absolute configuration at C-16 of the known compound 11 is reported herein for the first time. The anti-inflammatory activities of compounds 112 were assessed by measuring their inhibitory effect on N-formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release in human neutrophils. Metabolites 2, 5, and 11 were found to show moderate inhibitory activity on the generation of superoxide anion, while compounds 5, 8, 11, and 12 could effectively suppress elastase release in fMLP/CB-stimulated human neutrophil cells at 10 μM. All of the isolated diterpenoids did not exhibit cytotoxic activity (IC50 > 50 μM) towards a limited panel of cancer cell lines. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank
Mar. Drugs 2017, 15(9), 280; https://doi.org/10.3390/md15090280
Received: 11 August 2017 / Revised: 29 August 2017 / Accepted: 30 August 2017 / Published: 1 September 2017
Cited by 2 | PDF Full-text (1648 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular, 1
[...] Read more.
A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular, 1 possesses a β-D-xylopyranose. The structures of the new compounds were elucidated on the basis of spectroscopic analyses. The cytotoxicities of compounds 1–4 against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of these new compounds 1–4 were also evaluated by measuring their ability to suppress superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils. Compounds 2 and 3 were shown to exhibit significant cytotoxicity, and compounds 3 and 4 were also found to display attracting anti-inflammatory activities. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Sinulariolide Suppresses Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase through the PI3K/AKT/mTOR Signaling Pathway in Human Bladder Cancer Cells
Mar. Drugs 2017, 15(8), 238; https://doi.org/10.3390/md15080238
Received: 17 April 2017 / Revised: 26 July 2017 / Accepted: 26 July 2017 / Published: 2 August 2017
Cited by 4 | PDF Full-text (6121 KB) | HTML Full-text | XML Full-text
Abstract
Sinulariolide is a natural product extracted from the cultured-type soft coral Sinularia flexibilis, and possesses bioactivity against the movement of several types of cancer cells. However, the molecular pathway behind its effects on human bladder cancer remain poorly understood. Using a human
[...] Read more.
Sinulariolide is a natural product extracted from the cultured-type soft coral Sinularia flexibilis, and possesses bioactivity against the movement of several types of cancer cells. However, the molecular pathway behind its effects on human bladder cancer remain poorly understood. Using a human bladder cancer cell line as an in vitro model, this study investigated the underlying mechanism of sinulariolide against cell migration/invasion in TSGH-8301 cells. We found that sinulariolide inhibited TSGH-8301 cell migration/invasion, and the effect was concentration-dependent. Furthermore, the protein expressions of matrix metalloproteinases (MMPs) MMP-2 and MMP-9, as well as urokinase, were significantly decreased after 24-h sinulariolide treatment. Meanwhile, the increased expression of tissue inhibitors of metalloproteinases (TIMPs) TIMP-1 and TIMP-2 were in parallel with an increased concentration of sinulariolide. Finally, the expressions of several key phosphorylated proteins in the mTOR signaling pathway were also downregulated by sinulariolide treatment. Our results demonstrated that sinulariolide has significant effects against TSGH-8301 cell migration/invasion, and its effects were associated with decreased levels of MMP-2/-9 and urokinase expression, as well as increased TIMP-1/TIMP-2 expression. The inhibitory effects were mediated by reducing phosphorylation proteins of the PI3K, AKT, and mTOR signaling pathway. The findings suggested that sinulariolide is a good candidate for advanced investigation with the aim of developing a new drug for the treatment of human bladder cancer. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Sterols from the Octocoral Nephthea columnaris
Mar. Drugs 2017, 15(7), 212; https://doi.org/10.3390/md15070212
Received: 23 May 2017 / Revised: 26 June 2017 / Accepted: 1 July 2017 / Published: 4 July 2017
PDF Full-text (1262 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2
[...] Read more.
Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2 were elucidated by using spectroscopic methods and comparing the spectroscopic data with those of known related metabolites. Sterol 3 was found to suppress superoxide anion production and elastase secretion by human neutrophils. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle 24-Methyl-Cholesta-5,24(28)-Diene-3β,19-diol-7β-Monoacetate Inhibits Human Small Cell Lung Cancer Growth In Vitro and In Vivo via Apoptosis Induction
Mar. Drugs 2017, 15(7), 210; https://doi.org/10.3390/md15070210
Received: 19 April 2017 / Revised: 13 June 2017 / Accepted: 26 June 2017 / Published: 1 July 2017
Cited by 1 | PDF Full-text (2516 KB) | HTML Full-text | XML Full-text
Abstract
24-methyl-cholesta-5,24(28)-diene-3β,19-diol-7β-monoacetate (MeCDDA) is a natural steroid compound isolated from a wild-type soft coral (Nephthea erecta). The present study aimed to investigate the anti-small cell lung cancer (SCLC) effects of MeCDDA in vitro and in vivo, as well as to elucidate its
[...] Read more.
24-methyl-cholesta-5,24(28)-diene-3β,19-diol-7β-monoacetate (MeCDDA) is a natural steroid compound isolated from a wild-type soft coral (Nephthea erecta). The present study aimed to investigate the anti-small cell lung cancer (SCLC) effects of MeCDDA in vitro and in vivo, as well as to elucidate its underlying mechanism. Our results indicated that H1688 and H146 cells show relevant sensitivity to MeCDDA, and the exposure to MeCDDA in SCLC cells caused dose-dependent growth inhibitory responses. In addition, MeCDDA treatment promoted cell apoptosis and increased the activities of caspases in H1688 cells, reducing the mitochondrial membrane potential and stimulating the release of cytochrome c into the cytosol. Along with the increase in Bax expression and reduction in Bcl-2, the MeCDDA treatment also significantly decreased Akt and mTOR phosphorylation. Finally, MeCDDA treatment in the mouse xenograft model of H1688 cells exhibited significant inhibition of tumor growth, corroborating MeCDDA as a potential pre-clinical candidate for the treatment of SCLC. Overall, our results demonstrate that the cytotoxic effects of MeCDDA towards H1688 and H146 cells, possibly through the activation of the mitochondrial apoptotic pathway and inhibition of the PI3K/Akt/mTOR pathway, merit further studies for its possible clinical application in chemotherapy. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Open AccessArticle Isoprenoids from the Soft Coral Sarcophyton glaucum
Mar. Drugs 2017, 15(7), 202; https://doi.org/10.3390/md15070202
Received: 6 June 2017 / Revised: 16 June 2017 / Accepted: 22 June 2017 / Published: 27 June 2017
Cited by 2 | PDF Full-text (2119 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Five new isoprenoids, 3,4,8,16-tetra-epi-lobocrasol (1), 1,15β-epoxy-deoxysarcophine (2), 3,4-dihydro-4α,7β,8α-trihydroxy-Δ2-sarcophine (3), ent-sarcophyolide E (4), and 16-deacetyl- halicrasterol B (5) and ten known compounds 6‒15, were characterized from the marine soft coral Sarcophyton glaucum,
[...] Read more.
Five new isoprenoids, 3,4,8,16-tetra-epi-lobocrasol (1), 1,15β-epoxy-deoxysarcophine (2), 3,4-dihydro-4α,7β,8α-trihydroxy-Δ2-sarcophine (3), ent-sarcophyolide E (4), and 16-deacetyl- halicrasterol B (5) and ten known compounds 6‒15, were characterized from the marine soft coral Sarcophyton glaucum, collected off Taitung coastline. Their structures were defined by analyzing spectra data, especially 2D NMR and electronic circular dichroism (ECD). The structure of the known compound lobocrasol (7) was revised. Cytotoxicity potential of the isolated compounds was reported, too. Full article
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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