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Special Issue "Marine Glycosides"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 31 January 2018

Special Issue Editors

Guest Editor
Prof. Dr. Thomas E Adrian

Department of Physiology, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates
Website | E-Mail
Interests: identification of novel growth-related cancer therapeutic targets; cancer stem cells; lipoxygenase pathways in cancer; molecular mechanisms of cancer cachexia; drug combination studies
Guest Editor
Prof. Dr. Francisco Sarabia

Department of Organic Chemistry, University of Malaga, Malaga, Spain
Website | E-Mail
Phone: 34 952 134258
Fax: +34 952 131941
Interests: natural products; bioactive compounds; total synthesis; antitumor; antibiotics; cyclodepsipeptides; cyclopeptides
Guest Editor
Dr. Ivan Cheng-Sanchez

Department of Organic Chemistry, University of Malaga, Malaga, Spain
E-Mail
Interests: natural products; bioactive compound; total synthesis; antitumor; antibiotics; cyclodepsipeptides; cyclopeptides

Special Issue Information

Dear Colleagues,

In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides that they use as shark repellents.

The major interest in these compounds as potential drugs stems from the broad spectrum of biological effects. They have been shown to have antimicrobial, antifungal, anti-inflammatory, immune modulatory immune modulatory and anticancer effects. The anticancer effects of marine glycosides include cell cycle suppression, induction of apoptosis, inhibition of migration, invasion and metastasis, as well as antiangiogenesis. Marine glycosides influence membrane permeability and at the molecular level, have been shown to influence membrane transport through effects on transport carriers and pumps, as well as effects on ligand-gated and voltage-gated channels. Various marine glycosides have been shown to activate sphingomyelinase and ceramide synthesis, to inhibit topoisomerase activity, receptor tyrosine kinase activity, multidrug resistance protein activity and to antagonize eicosanoid receptors.

This Special Issue will cover the entire scope of marine organism-derived glycosides that are of potential value as pharmaceutical agents or leads. These include, but are not limited to, tetracyclic triterpene glycosides; other triterpene glycosides; steroid glycosides; and glycosides of non-isoprenoid aglycones.

Prof. Dr. Thomas E Adrian
Prof. Dr. Francisco Sarabia
Dr. Ivan Cheng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Marine glycosides
  • Triterpene glycosides
  • Steroid glycosides
  • Glycolipids
  • Glycosides of non-isoprenoid aglycones
  • Cancer
  • İnflammation
  • Antitumoral
  • Anti-microbial
  • Anti-fungal
  • İmmune modulation

Published Papers (3 papers)

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Research

Open AccessArticle Metabolite Profiling of Triterpene Glycosides of the Far Eastern Sea Cucumber Eupentacta fraudatrix and Their Distribution in Various Body Components Using LC-ESI QTOF-MS
Mar. Drugs 2017, 15(10), 302; doi:10.3390/md15100302
Received: 18 August 2017 / Revised: 21 September 2017 / Accepted: 30 September 2017 / Published: 2 October 2017
PDF Full-text (3365 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The Far Eastern sea cucumber Eupentacta fraudatrix is an inhabitant of shallow waters of the south part of the Sea of Japan. This animal is an interesting and rich source of triterpene glycosides with unique chemical structures and various biological activities. The objective
[...] Read more.
The Far Eastern sea cucumber Eupentacta fraudatrix is an inhabitant of shallow waters of the south part of the Sea of Japan. This animal is an interesting and rich source of triterpene glycosides with unique chemical structures and various biological activities. The objective of this study was to investigate composition and distribution in various body components of triterpene glycosides of the sea cucumber E. fraudatrix. We applied LC-ESI MS (liquid chromatography–electrospray mass spectrometry) of whole body extract and extracts of various body components for metabolic profiling and structure elucidation of triterpene glycosides from the E. fraudatrix. Totally, 54 compounds, including 26 sulfated, 18 non-sulfated and 10 disulfated glycosides were detected and described. Triterpene glycosides from the body walls, gonads, aquapharyngeal bulbs, guts and respiratory trees were extracted separately and the distributions of the detected compounds in various body components were analyzed. Series of new glycosides with unusual structural features were described in E. fraudatrix, which allow clarifying the biosynthesis of these compounds. Comparison of the triterpene glycosides contents from the five different body components revealed that the profiles of triterpene glycosides were qualitatively similar, and only some quantitative variabilities for minor compounds were observed. Full article
(This article belongs to the Special Issue Marine Glycosides)
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Figure 1

Open AccessFeature PaperArticle Nine New Triterpene Glycosides, Magnumosides A1–A4, B1, B2, C1, C2 and C4, from the Vietnamese Sea Cucumber Neothyonidium (=Massinium) magnum: Structures and Activities against Tumor Cells Independently and in Synergy with Radioactive Irradiation
Mar. Drugs 2017, 15(8), 256; doi:10.3390/md15080256
Received: 25 July 2017 / Revised: 8 August 2017 / Accepted: 11 August 2017 / Published: 16 August 2017
Cited by 1 | PDF Full-text (1689 KB) | HTML Full-text | XML Full-text
Abstract
Nine new sulfated triterpene glycosides, magnumosides A1 (1), A2 (2), A3 (3), A4 (4), B1 (5), B2 (6), C1 (7), C2
[...] Read more.
Nine new sulfated triterpene glycosides, magnumosides A1 (1), A2 (2), A3 (3), A4 (4), B1 (5), B2 (6), C1 (7), C2 (8) and C4 (9) as well as a known colochiroside B2 (10) have been isolated from the tropical Indo-West Pacific sea cucumber Neothynidium (=Massinium) magnum (Phyllophoridae, Dendrochirotida) collected in the Vietnamese shallow waters. The structures of new glycosides were elucidated by 2D NMR spectroscopy and mass-spectrometry. All the isolated new glycosides were characterized by the non-holostane type lanostane aglycones having 18(16)-lactone and 7(8)-double bond and differed from each other by the side chains and carbohydrate moieties structures. Magnumoside A1 (1) has unprecedented 20(24)-epoxy-group in the aglycone side chain. Magnumosides of the group A (14) contained disaccharide monosulfated carbohydrate moieties, of the group B (5, 6)—tetrasaccharide monosulfated carbohydrate moieties and, finally, of the group C (79)—tetrasaccharide disulfated carbohydrate moieties. The cytotoxic activities of the compounds 19 against mouse spleen lymphocytes, the ascites form of mouse Ehrlich carcinoma cells, human colorectal carcinoma DLD-1 cells as well as their hemolytic effects have been studied. Interestingly, the erythrocytes were more sensitive to the glycosides action than spleenocytes and cancer cells tested. The compounds 3 and 7 significantly inhibited the colony formation and decreased the size of colonies of DLD-1 cancer cells at non-cytotoxic concentrations. Moreover, the synergism of effects of radioactive irradiation and compounds 3 and 79 at subtoxic doses on proliferation of DLD-1 cells was demonstrated. Full article
(This article belongs to the Special Issue Marine Glycosides)
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Figure 1

Open AccessArticle Poecillastrosides, Steroidal Saponins from the Mediterranean Deep-Sea Sponge Poecillastra compressa (Bowerbank, 1866)
Mar. Drugs 2017, 15(7), 199; doi:10.3390/md15070199
Received: 17 May 2017 / Revised: 15 June 2017 / Accepted: 21 June 2017 / Published: 26 June 2017
PDF Full-text (756 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The first chemical investigation of the Mediterranean deep-sea sponge Poecillastra compressa (Bowerbank, 1866) led to the identification of seven new steroidal saponins named poecillastrosides A–G (17). All saponins feature an oxidized methyl at C-18 into a primary alcohol or
[...] Read more.
The first chemical investigation of the Mediterranean deep-sea sponge Poecillastra compressa (Bowerbank, 1866) led to the identification of seven new steroidal saponins named poecillastrosides A–G (17). All saponins feature an oxidized methyl at C-18 into a primary alcohol or a carboxylic acid. While poecillastrosides A–D (14) all contain an exo double bond at C-24 of the side-chain and two osidic residues connected at O-2′, poecillastrosides E–G (57) are characterized by a cyclopropane on the side-chain and a connection at O-3′ between both sugar units. The chemical structures were elucidated through extensive spectroscopic analysis (High-Resolution Mass Spectrometry (HRESIMS), 1D and 2D NMR) and the absolute configurations of the sugar residues were assigned after acidic hydrolysis and cysteine derivatization followed by LC-HRMS analyses. Poecillastrosides D and E, bearing a carboxylic acid at C-18, were shown to exhibit antifungal activity against Aspergillus fumigatus. Full article
(This article belongs to the Special Issue Marine Glycosides)
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