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Mar. Drugs 2017, 15(12), 365; doi:10.3390/md15120365

Chemical Profiling and Bioactivity of Body Wall Lipids from Strongylocentrotus droebachiensis

1
Saint-Petersburg Institute of Pharmacy, Leningrad Region, Vsevolozhsky District, Kuzmolovo P 245, 188663 Saint-Petersburg, Russia
2
Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5E), FI-00014 Helsinki, Finland
3
VTT Technical Research Centre of Finland Ltd., P.O. Box 1000 (Tietotie 2), FI-02044 VTT Espoo, Finland
*
Author to whom correspondence should be addressed.
Received: 31 August 2017 / Revised: 9 November 2017 / Accepted: 15 November 2017 / Published: 24 November 2017
(This article belongs to the Special Issue Marine Lipids 2017)
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Abstract

The lipids from gonads and polyhydroxynaphthoquinone pigments from body walls of sea urchins are intensively studied. However, little is known about the body wall (BW) lipids. Ethanol extract (55 °C) contained about equal amounts of saturated (SaFA) and monounsaturated fatty acids (MUFA) representing 60% of total fatty acids, with myristic, palmitic and eicosenoic acids as major SaFAs and MUFAs, respectively. Non-methylene-interrupted dienes (13%) were composed of eicosadienoic and docosadienoic acids. Long-chain polyunsaturated fatty acids (LC-PUFA) included two main components, n6 arachidonic and n3 eicosapentaenoic acids, even with equal concentrations (15 μg/mg) and a balanced n6/n3 PUFA ratio (0.86). The UPLC-ELSD analysis showed that a great majority of the lipids (80%) in the ethanolic extract were phosphatidylcholine (60 μg/mg) and phosphatidylethanolamine (40 μg/mg), while the proportion of neutral lipids remained lower than 20%. In addition, alkoxyglycerol derivatives—chimyl, selachyl, and batyl alcohols—were quantified. We have assumed that the mechanism of action of body wall lipids in the present study is via the inhibition of MAPK p38, COX-1, and COX-2. Our findings open the prospective to utilize this lipid fraction as a source for the development of drugs with anti-inflammatory activity. View Full-Text
Keywords: sea urchin; body wall lipids; inhibition of p38 MAPK; COX; GC-MS; UPLC-ELSD sea urchin; body wall lipids; inhibition of p38 MAPK; COX; GC-MS; UPLC-ELSD
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Shikov, A.N.; Laakso, I.; Pozharitskaya, O.N.; Seppänen-Laakso, T.; Krishtopina, A.S.; Makarova, M.N.; Vuorela, H.; Makarov, V. Chemical Profiling and Bioactivity of Body Wall Lipids from Strongylocentrotus droebachiensis. Mar. Drugs 2017, 15, 365.

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