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Mar. Drugs 2017, 15(12), 389; doi:10.3390/md15120389

α-Pyrone Polyketides from Streptomyces ambofaciens BI0048, an Endophytic Actinobacterial Strain Isolated from the Red Alga Laurencia glandulifera

1
Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece
2
Laboratory of Biotechnology, School of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str., Zografou Campus, Athens 15780, Greece
*
Author to whom correspondence should be addressed.
Received: 2 November 2017 / Revised: 5 December 2017 / Accepted: 7 December 2017 / Published: 14 December 2017
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Abstract

Four new (14) and six previously reported (510) α-pyrone polyketides, along with benzoic acid, hydrocinnamic acid, and (E)-cinnamic acid, were isolated from the organic extract resulting from the cultivation of the algicolous strain Streptomyces ambofaciens BI0048, which in turn was isolated from the inner tissues of the red alga Laurencia glandulifera. The structure elucidation of the isolated natural products was based on extensive analysis of their spectroscopic data (NMR, MS, UV, IR). Compounds 110 were evaluated for their antibacterial and cytotoxic activities against two multidrug-resistant strains of Staphylococcus aureus and one strain of Escherichia coli, as well as two human cancer cell lines. View Full-Text
Keywords: Streptomyces ambofaciens; algicolous actinobacterium; endophytic strain; polyketides; α-pyrone; structure elucidation; bioactivity evaluation Streptomyces ambofaciens; algicolous actinobacterium; endophytic strain; polyketides; α-pyrone; structure elucidation; bioactivity evaluation
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Rab, E.; Kekos, D.; Roussis, V.; Ioannou, E. α-Pyrone Polyketides from Streptomyces ambofaciens BI0048, an Endophytic Actinobacterial Strain Isolated from the Red Alga Laurencia glandulifera. Mar. Drugs 2017, 15, 389.

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