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Mar. Drugs 2017, 15(12), 378; https://doi.org/10.3390/md15120378

Lobocrassin B Induces Apoptosis of Human Lung Cancer and Inhibits Tumor Xenograft Growth

1
Institute of Biomedical Science, National Chung-Hsing University, Taichung 40227, Taiwan
2
Department of Internal Medicine, Division of Chest Medicine, Changhua Christian Hospital, Changhua 500, Taiwan
3
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
4
Department of Health and Nutrition, Asia University, Taichung 413, Taiwan
5
Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 19 September 2017 / Revised: 15 November 2017 / Accepted: 28 November 2017 / Published: 4 December 2017
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Abstract

Lobocrassin B, a natural cembrane-type compound isolated from the soft coral Lobophytum crassum, has been shown to have significant biological effects, including anticancer activity. As the most common cause of cancer mortality worldwide, lung cancer remains a major concern threatening human health. In the current study, we conducted in vitro experiments to demonstrate the inhibiting effect of Lobocrassin B on CL1-5 and H520 human lung cancer cells growth and to explore the underlying mechanisms, as well as in nude mice bearing CL1-5 tumor xenografts. Lobocrassin B exerted cytotoxic effects on lung cancer cells, as shown by decreasing cell viability, and inducing apoptosis, oxidative stress and mitochondrial dysfunction. In addition, the increased level of Bax, cleaved caspase-3, -9 and -8, and the suppression of Bcl-2 were observed in the Lobocrassin B treated cells. Moreover, in vivo assays verified the significance of these results, revealing that Lobocrassin B inhibited CL1-5 tumor xenograft growth and that inhibitory effects were accompanied by a marked increase in tumor cell apoptosis. In conclusion, the results suggested that Lobocrassin B could be a potential anticancer compound for its propensity to inhibit growth and induce apoptosis in human lung cancer cells. View Full-Text
Keywords: Lobocrassin B; lung cancer; apoptosis; mitochondria; caspase; xenograft Lobocrassin B; lung cancer; apoptosis; mitochondria; caspase; xenograft
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Lin, M.-X.; Lin, S.-H.; Li, Y.-R.; Chao, Y.-H.; Lin, C.-H.; Su, J.-H.; Lin, C.-C. Lobocrassin B Induces Apoptosis of Human Lung Cancer and Inhibits Tumor Xenograft Growth. Mar. Drugs 2017, 15, 378.

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