2,057,193 Results Found

Patient-derived cancer organoids (PDOs) are increasingly used to investigate tumor biology, treatment response, and precision oncology, yet their correspondence to the tumors from which they originate is often summarized using global terms such as &l...

The performance of biopolymer films depends on both composition and formation conditions. This study evaluated films containing constant amounts of Nopal-Opuntia spp. mucilage, glycerol, and vinegar using a 16-run mixture–process design with fo...

In this study, we proposed and evaluated a new dielectrophoresis (DEP)-based device for the high-throughput, non-invasive separation of cells with similar physical properties. Although DEP is an established technology for separating biological partic...

Capturing CO₂ upstream of artificial photosynthesis is worthwhile only if the utility emissions of the capture step do not offset the captured mass. This study compares 30 wt% methyldiethanolamine (MDEA) absorption, temperature swing adsorption (TSA)...

This work aims to characterize the bioactive metabolite profile and in vitro multifunctional properties of postbiotic cell-free supernatants (Postbiotic-CFSs) derived from three lactic acid bacteria (Levilactobacillus brevis S27, Lactiplantibacillus ...

Background: Rapid screening methods reflecting the metabolic profile of urine are promising for assessing the risk of decreased renal function in children with obstructive uropathies. The aim of this pilot study was to evaluate the applicability of a...

Pyruvate carboxylase (PYC), a multifunctional biotin-dependent enzyme, is essential in diverse metabolic cascades including gluconeogenesis and the tricarboxylic acid (TCA) cycle. This study aimed to dissect the physiological roles of PYC and its suc...

Diabetes is associated with an increased risk of tuberculosis (TB), but whether the class of glucose-lowering therapy is associated with TB outcomes remains uncertain. We conducted a retrospective observational cohort study to examine the association...

The circularity of waste-derived rigid unplasticised poly (vinyl chloride) (PVC-u) is constrained by heterogeneous waste-stream sources, degraded material quality, legacy additives, and inconsistent decision criteria spanning technical, environmental...

The emergence of infections caused by Scedosporium/Lomentospora and Mucorales species poses a major clinical challenge due to their intrinsic resistance to multiple antifungal drugs and the limited number of therapeutic options available. In this stu...

Drought limits pea (Pisum sativum L.) productivity by reducing growth, photosynthesis, and reproductive success, yet comparative field data across contrasting canopy morphologies are scarce. This study evaluated five pea varieties—Alejandrita (...

Cryptotanshinone (CTS), a bioactive diterpenoid extracted from Salvia miltiorrhiza Bunge, has long been recognized as a traditional Chinese herbal compound. This study reveals that CTS exerts potent anti-hypertrophic effects against angiotensin II (A...

Objectives: The objective of this study was to assess the suture distraction technique (SDT) for closing decompression wounds resulting from acute compartment syndrome (ACS) of the lower leg, and to examine whether it may serve as an alternative to s...

Background/Objectives: To assess guideline concordance and indication documentation of new allopurinol prescriptions and whether these differed across clinical specialties. Methods: A retrospective study at a tertiary academic center in Riyadh, Saudi...

The sensitive detection of tumor markers is of great significance for clinical diagnosis. Due to the extremely low abundance of early tumor biomarkers and severe background interference from biological matrices, traditional single-modal atomolar biol...

Background and Objectives: Parkinson’s disease (PD) is frequently associated with postural instability, including camptocormia, an involuntary anterior flexion of the thoracolumbar spine. This retrospective observational pilot study evaluated t...

Natural products remain an important source of structurally diverse compounds for the discovery of new antimicrobial agents. Gliricidia sepium (Jacq.) Kunth ex Walp. is a medicinal species widely distributed in tropical regions and is recognized as a...

The evolving hydrogen transmission network is a key component of Europe’s energy transition. This study assesses whether the planned European hydrogen transmission grid can accommodate projected regional supply and demand in 2030, 2040, and 205...

Background: Long-term quality-of-life (QOL) outcomes after ventral primary and incisional hernia repair are underreported, especially beyond the early postoperative period. This cross-sectional study evaluated postoperative functional status, mental...

Alleviating the cultivated land pressure in the black soil region of Northeast China is an essential requirement for safeguarding national food security. Taking 34 prefecture-level and above cities in the Northeast China black soil region from 2008 t...

Gross extraction yield alone cannot establish product conformity or broader economic and environmental performance. This critical integrative review examines evidence linking laboratory findings to industrially relevant claims for plant-derived biopr...

Background/Objectives: Neurosyphilis is a recognized treatable mimic of amyotrophic lateral sclerosis (ALS); syphilis serology is commonly included in the work-up of suspected motor neuron disease. We describe the converse situation: neurosyphilis th...

Hydropower-dominated systems can experience ultra-low-frequency oscillations (ULFOs, below 0.1 Hz) associated with hydro-governor dynamics and the water hammer effect. This paper investigates how wind power equipped with auxiliary frequency control m...

Children can increase fruit and vegetable intake by consuming smoothies. However, most commercial smoothies contain excessive sugar due to the high proportion of apple juice within recipes. Including children, particularly those from potentially unde...

Nitrogen deficiency limits oat growth and productivity, but the molecular basis of contrasting low-nitrogen responses among oat germplasms remains poorly understood. This study compared the low-nitrogen-tolerant germplasm Jiayan No.2 with the low-nit...

Wearable sensors offer promising solutions for continuous gait monitoring in healthcare, rehabilitation, and sports. In this paper, a novel, soft, flexible, and easily made wearable sensor to detect the pressure generated by human gait was developed....

Carpal tunnel syndrome (CTS) is a common condition caused by increased carpal tunnel pressure and compression of the median nerve. Wrist–hand orthosis is widely used as a nonsurgical treatment to maintain the wrist in a near-neutral position an...

Five compounds with the formula Ln₂Zr₂O₇ (Ln = La, Nd, Sm, Eu, and Gd) were investigated. These materials exhibit important physicochemical properties and find practical applications for the development of high-temperature barriers, gas traps, and th...

Thirty-four binary systems were prepared by co-sputtering dissimilar metals onto a moving substrate. In the present work, the experimentally controlled size parameter is the nominal thickness of a single metal sublayer deposited during one substrate...

To investigate a combined chemical–physical modification strategy for improving the wetting–drying resistance of coal gangue concrete (CGC), CGC was prepared by replacing 25 wt.% of natural coarse aggregate with coal gangue coarse aggrega...

The efficacy of microbial inoculants in enhancing plant drought tolerance is context-dependent, varying with drought severity and the dynamic interactions within the plant–soil microbe system. We conducted a two-factor pot experiment using Achn...

Heme promotes oxidative modification of low-density lipoprotein (LDL), a process implicated in atherosclerosis. However, the fate of heme during LDL oxidation and the mechanisms governing its degradation remain poorly understood. We investigated heme...

Larix sibirica is a conifer and a renewable source of chemically diverse constituents with pharmacological uses. This review examines its phytochemical composition, extraction strategies, and reported pharmacological activities, including preliminary...

This paper exploits the staggered establishment of 43 social credit system pilot cities across two batches in China (2015 and 2016) as a quasi-natural experiment to examine the effect of institution-based trust on firm-level supply chain risk. Using...

Background/Objectives: This is the first study in Eastern Europe to integrate skin and iris phenotypic characteristics with selected polymorphisms in genes related to skin aging, melanogenesis and skin pigmentation, and inflammatory regulation in rel...

Against the backdrop of high-quality development, diagnosing coupling mismatches between new quality productive forces and urban resilience is crucial for sustainable, resilient regional growth. This study diagnoses these spatial network mismatches a...

Background: Methyltransferase-like 26 (METTL26) is a poorly characterized member of the METTL family that has been included in previous pan-cancer analyses, but its disease-specific clinical and molecular relevance in head and neck squamous cell carc...

Multi-pass cold drawing and subsequent annealing are critical processing steps determining the microstructure and mechanical performance of vanadium wires, as they directly influence the performance of the final product. This study systematically inv...

Background: Chemotherapy-induced peripheral neuropathy (CIPN) affects two-thirds of patients who receive neurotoxic chemotherapy. In almost half of these patients, CIPN is persistent, with limited treatment options. Exercise-based rehabilitation show...

Published aphid volatile records are difficult to explore when chemical annotations, identification confidence and biological context are stored separately. We developed VOC·BIO Library to integrate these evidence layers with reproducible comp...

Urban morphology strongly affects spatial quality and residents’ quality of life, yet many assessments rely on aggregated indicators and overlook causal links between street-scale attributes. This study proposes a multicriteria framework that c...

Sickle cell disease is associated with abnormal erythrocyte deformation and altered blood rheology, which may increase resistance to blood flow and contribute to impaired tissue perfusion. The presence of arterial stenosis can further modify the haem...

Sleep and nutrition are closely interconnected through behavioral, metabolic, and circadian pathways, yet the strength of evidence varies considerably across dietary exposures. This narrative review synthesizes current evidence on nutrients, foods, d...

Infections caused by the Klebsiella pneumoniae species complex (KpSC) are particularly challenging to manage, especially in healthcare systems. Members of the KpSC are frequently identified as K. pneumoniae by conventional automated or proteomic syst...

Wearable health monitoring is expanding from physical signals, such as heart rate and body temperature, to molecular information at body interfaces and in biofluids. Raman spectroscopy provides chemically specific vibrational fingerprints and support...

The “closed-loop design, open-loop operation” scheme traditionally adopted by distribution networks results in limited power-flow regulation capability and insufficient supply reliability. Existing flexible interconnection solutions mostl...

Genetic and molecular studies increasingly explain anesthetic and analgesic responses at the level of defined conductances, neuronal populations, and injury states. Their clinical implications depend on distinguishing target engagement from changes i...

Background/Objectives: Biofilm formation is a major bacterial survival strategy in response to antibiotic stress. The bacterial second messenger cyclic di-GMP (c-di-GMP) is a central regulator of biofilm development. Sub-minimum inhibitory concentrat...

The ovarian lymphatic vasculature has emerged as a potential regulator of ovarian function, yet its role in follicular development remains poorly defined. Here, we aimed to elucidate the dynamic changes in ovarian lymphatic vessels during follicular...

Owing to their well-established formulations and high performance, traditional cement-based materials are among the most widely used construction materials worldwide. However, their production generates substantial greenhouse gas emissions and relies...