Special Issue "Solid Phase Synthesis"
Deadline for manuscript submissions: 15 May 2018
Prof. Fernando Albericio
1. School of Chemistry, University of KwaZulu-Natal, Durban 4001, South Africa
2. Department of Organic Chemistry, University of Barcelona, 08028-Barcelona, Spain
Website1 | Website2 | E-Mail
Fax: +34 93 403 71 26
Interests: solid-phase chemistry, combinatorial chemistry, drug delivery systems, peptides, peptide drug conjugates, orthogonal chemistry, drug discovery, biomaterials
Dr. Jan Spengler
Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, E-08028 Barcelona, Spain
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Phone: ++34 934037127
Interests: solid-phase chemistry; protecting groups; backbone modified peptides; depsipeptides; synthesis of rare and non-natural peptide building blocks
This Special Issue of Molecules is dedicated to “Solid-Phase Synthesis”. The concept of solid-phase (SP) peptide synthesis was revealed by Bruce Merrifield in 1963 and its potential for general organic chemistry was soon recognized. However, it was not until the onset of combinatorial chemistry in early 1990s when the application of SP organic synthesis started to flourish.
Today, SP synthesis is widely used particularly in the area of drug discovery. Critical advantages of SP synthesis include very efficient isolation of intermediates by washing resin beads. Consequently, high boiling solvents, such as DMF and DMSO, can be used beneficially without the need to evaporate them.
Drug discovery efforts benefited from the time efficient synthesis of compounds decks for high throughput screening as well as dedicated libraries for hit/lead optimization. Diversity oriented synthesis (DOS) that was mainly focused on synthesis of structurally dissimilar compounds has now shifted to biology oriented synthesis (BIOS) focused on the design of structures resembling natural products, including complex chiral molecular scaffolds with three-dimensional architecture.
This Special Issue will provide an opportunity to publish research results dedicated to all aspects of SP synthesis including, but not limited to, development of new chemical transformations, new resins, linkers, methodology, catalyst development, combinatorial synthesis, solid-phase reagents, synthesis of drug-like molecules, peptides, preparation of compound decks for high throughput screening, etc.
Prof. Viktor Krchnak
- development of new chemical transformations
- new resins
- catalyst development
- combinatorial synthesis
- solid-phase reagents
- synthesis of drug-like molecules
- preparation of compound decks for high throughput screening