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Special Issue "Organic Synthesis on Solid Phase"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: closed (10 April 2015)

Special Issue Editors

Guest Editor
Prof. Fernando Albericio

1. School of Chemistry, University of KwaZulu-Natal, Durban 4001, South Africa
2. Department of Organic Chemistry, University of Barcelona, 08028-Barcelona, Spain
Website1 | Website2 | E-Mail
Fax: +34 93 403 71 26
Interests: solid-phase chemistry, combinatorial chemistry, drug delivery systems, peptides, peptide drug conjugates, orthogonal chemistry, drug discovery, biomaterials
Guest Editor
Dr. Jan Spengler

Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, E-08028 Barcelona, Spain
Website | E-Mail
Phone: ++34 934037127
Interests: solid-phase chemistry; protecting groups; backbone modified peptides; depsipeptides; synthesis of rare and non-natural peptide building blocks

Special Issue Information

Dear Colleagues,

From its beginnings in the 1960s, solid phase chemistry, i.e., chemical synthesis involving one immobilized reactant, has evolved to become a standard technique in many fields of organic chemistry, especially peptide synthesis and combinatorial chemistry. The great advantage of the easy removal of immobilized products by simple filtration has attracted both industry and academic research to contribute substantial effort to optimize reactions performed on solid supports which is witnessed by the development of a plethora of specialized chemical and analytical tools and the use of microwave heating. This special issue of “Molecules” is devoted to reporting recent applications of the concept of solid phase chemistry.

Prof. Dr. Fernando Albericio
Dr. Jan Spengler
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


Keywords

  • solid phase peptide synthesis
  • solid phase organic synthesis
  • polymeric supports
  • linkers and handles
  • immobilized reagents
  • microwave reactions
  • combinatorial chemistry
  • analytical tools

Published Papers (2 papers)

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Research

Open AccessCommunication Reactivity of Aryl Halides for Reductive Dehalogenation in (Sea)water Using Polymer-Supported Terpyridine Palladium Catalyst
Molecules 2015, 20(6), 9906-9914; doi:10.3390/molecules20069906
Received: 18 March 2015 / Accepted: 26 May 2015 / Published: 28 May 2015
Cited by 2 | PDF Full-text (693 KB) | HTML Full-text | XML Full-text
Abstract
A polymer-supported terpyridine palladium complex was prepared. The complex was found to promote hydrodechlorination of aryl chlorides with potassium formate in seawater. Generally, reductive cleavage of aryl chlorides using transition metal catalysts is more difficult than that of aryl bromides and iodides (reactivity:
[...] Read more.
A polymer-supported terpyridine palladium complex was prepared. The complex was found to promote hydrodechlorination of aryl chlorides with potassium formate in seawater. Generally, reductive cleavage of aryl chlorides using transition metal catalysts is more difficult than that of aryl bromides and iodides (reactivity: I > Br > Cl); however, the results obtained did not follow the general trend. Therefore, we investigated the reaction inhibition agents and found a method to remove these inhibitors. The polymeric catalysts showed high catalytic activity and high reusability for transfer reduction in seawater. Full article
(This article belongs to the Special Issue Organic Synthesis on Solid Phase)
Figures

Open AccessCommunication Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave
Molecules 2015, 20(4), 5276-5285; doi:10.3390/molecules20045276
Received: 13 February 2015 / Revised: 9 March 2015 / Accepted: 18 March 2015 / Published: 24 March 2015
Cited by 3 | PDF Full-text (841 KB) | HTML Full-text | XML Full-text
Abstract
The translation of organometallic reactions into a microwave reactor has numerous advantages. Herein, we describe the application of a previously developed solid-supported Glaser-Hay reaction to microwave conditions. Overall, an array of diynes has been prepared demonstrating the ability to conduct chemoselective reactions in
[...] Read more.
The translation of organometallic reactions into a microwave reactor has numerous advantages. Herein, we describe the application of a previously developed solid-supported Glaser-Hay reaction to microwave conditions. Overall, an array of diynes has been prepared demonstrating the ability to conduct chemoselective reactions in the microwave within 20 min compared to the 16 h thermal conditions. Moreover, non-microwave transparent alkynes have been found to react more quickly, preventing catalyst quenching, and resulting in higher yields. Full article
(This article belongs to the Special Issue Organic Synthesis on Solid Phase)
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