Special Issue "Combinatorial Synthesis"
QuicklinksA special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (31 January 2013)
Special Issue Editors
Guest Editor
Prof. Dr. Fernando Albericio
1 Institute for Research in Biomedicine (IRB Barcelona), Parc CientÃfic de Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain
2 School of Chemistry, University of KwaZulu-Natal, Durban 4001, South Africa
Website: http://www.pcb.ub.es/fama
E-Mail: albericio@irbbarcelona.org
Phone: +34 93 403 70 88
Fax: +34 93 403 71 26
Interests: marine natural products; bioactive natural products; peptides; solid-phase chemistry; combinatorial chemistry; drug delivery systems
Guest Editor
Prof. Dr. Gert Kruger
School of Chemistry, University of KwaZulu-Natal, Durban 4001, South Africa
Website: http://chemistrywst.ukzn.ac.za/Staff_profiles/Prof_Gert_Kruger.aspx
E-Mail: KRUGER@ukzn.ac.za
Interests: chiral catalysis; cage chemistry; pharmaceutical applications of cage compounds
Special Issue Information
Dear Colleagues,
Combinatorial chemistry is a broad field that initially started with peptide synthesis but soon migrated to a much broader range of chemical reactions and applications. The field now involves various synthetic approaches, analytical methods and a magnitude of drug related applications. Synthetic methods involve solid phase and solution phase synthesis, spot synthesis, multicomponent reactions, combinatorial synthesis based on molecular recognition, combinatorial electrochemistry, cosmix-plexing, nucleotides, recombinant DNA synthesis, methods based on Serial Analysis of Gene Expression (SAGE), oligosaccharides, combinatorial catalysis, antibody production, combinatorial biosynthesis, shotgun bacteriophage display cloning and many more. Multiple analytical techniques were developed to facilitate improved methods, and high throughput screening in combination with combinatorial synthesis has also been developed. Finally, the combinatorial philosophy has also been applied to the field of material science.
This special issue of Molecules will consider any submission associated with combinatorial approaches related to the above mentioned topics.
Prof. Dr. Fernando Albericio
Prof. Dr. Gert Kruger
Guest Editors
Submission
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).
Keywords
- combinatorial chemistry
- combinatorial biology
- combinatorial material sciences
- paralell strategies
- high throughput screening
Published Papers (1 paper)
 Molecules 2013, 18(4), 4120-4139; doi:10.3390/molecules18044120
Received: 9 January 2013; in revised form: 2 April 2013 / Accepted: 3 April 2013 / Published: 8 April 2013
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Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Integrated Solid Phase Combinatorial Chemistry
Author: Morten Meldal
Affiliation: Department of Chemistry, Nano Science Center, Copenhagen University, Denmark
Abstract: Review of methods that takes into account all the steps of molecular evolution in Solid Phase Combinatorial Chemistry These includes the generation of compound libraries through quantitative chemical transformations, incorporation of selection criteria and auxiliary molecules that allow screening on solid support, screening systems that allow combinatorial selection of active substances without false positives, structure determination from single beads or positions, and reiteration. Particular emphases will be on the encoding in solid phase chemistry and biology.
Last update: 4 February 2013