Special Issue "Combinatorial Synthesis"


A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (20 January 2014)

Special Issue Editors

Guest Editor
Prof. Dr. Fernando Albericio
1 School of Chemistry, Yachay Tech, Yachay City of Knowledge, 100119-Urcuqui, Ecuador
2 Institute for Research in Biomedicine (IRB Barcelona), Parc Científic de Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain
3 School of Chemistry, University of KwaZulu-Natal, Durban 4001, South Africa
Website: http://www.pcb.ub.es/fama
E-Mail: albericio@irbbarcelona.org
Phone: +34 93 403 70 88
Fax: +34 93 403 71 26
Interests: marine natural products; bioactive natural products; peptides; solid-phase chemistry; combinatorial chemistry; drug delivery systems

Guest Editor
Prof. Dr. Gert Kruger
School of Chemistry, University of KwaZulu-Natal, Durban 4001, South Africa
Website: http://chemistrywst.ukzn.ac.za/Staff_profiles/Prof_Gert_Kruger.aspx
E-Mail: KRUGER@ukzn.ac.za
Interests: chiral catalysis; cage chemistry; pharmaceutical applications of cage compounds

Special Issue Information

Dear Colleagues,

Combinatorial chemistry is a broad field that initially started with peptide synthesis but soon migrated to a much broader range of chemical reactions and applications. The field now involves various synthetic approaches, analytical methods and a magnitude of drug related applications. Synthetic methods involve solid phase and solution phase synthesis, spot synthesis, multicomponent reactions, combinatorial synthesis based on molecular recognition, combinatorial electrochemistry, cosmix-plexing, nucleotides, recombinant DNA synthesis, methods based on Serial Analysis of Gene Expression (SAGE), oligosaccharides, combinatorial catalysis, antibody production, combinatorial biosynthesis, shotgun bacteriophage display cloning and many more. Multiple analytical techniques were developed to facilitate improved methods, and high throughput screening in combination with combinatorial synthesis has also been developed. Finally, the combinatorial philosophy has also been applied to the field of material science.

This special issue of Molecules will consider any submission associated with combinatorial approaches related to the above mentioned topics.

Prof. Dr. Fernando Albericio
Prof. Dr. Gert Kruger
Guest Editors


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).


  • combinatorial chemistry
  • combinatorial biology
  • combinatorial material sciences
  • paralell strategies
  • high throughput screening

Published Papers (3 papers)

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Displaying article 1-3
p. 6330-6348
by  and
Molecules 2014, 19(5), 6330-6348; doi:10.3390/molecules19056330
Received: 7 February 2014; in revised form: 12 May 2014 / Accepted: 13 May 2014 / Published: 16 May 2014
Show/Hide Abstract | Cited by 2 | PDF Full-text (1425 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Combinatorial Synthesis)
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p. 14519-14528
by , , , , , ,  and
Molecules 2013, 18(12), 14519-14528; doi:10.3390/molecules181214519
Received: 30 September 2013; in revised form: 19 November 2013 / Accepted: 19 November 2013 / Published: 25 November 2013
Show/Hide Abstract | PDF Full-text (365 KB)
(This article belongs to the Special Issue Combinatorial Synthesis)
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p. 4120-4139
by , , ,  and
Molecules 2013, 18(4), 4120-4139; doi:10.3390/molecules18044120
Received: 9 January 2013; in revised form: 2 April 2013 / Accepted: 3 April 2013 / Published: 8 April 2013
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Last update: 9 July 2013

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