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Molecules 2010, 15(7), 4961-4983; doi:10.3390/molecules15074961
Article

Solid-Phase Synthetic Route to Multiple Derivatives of a Fundamental Peptide Unit

1,* , 1, 2, 2 and 1,*
Received: 7 June 2010; in revised form: 23 June 2010 / Accepted: 12 July 2010 / Published: 20 July 2010
(This article belongs to the Special Issue Solid Phase Synthesis)
Download PDF [357 KB, uploaded 18 June 2014]
Abstract: Amino acids are Nature’s combinatorial building blocks. When substituted on both the amino and carboxyl sides they become the basic scaffold present in all peptides and proteins. We report a solid-phase synthetic route to large combinatorial variations of this fundamental scaffold, extending the variety of substituted biomimetic molecules available to successfully implement the Distributed Drug Discovery (D3) project. In a single solid-phase sequence, compatible with basic amine substituents, three-point variation is performed at the amino acid a-carbon and the amino and carboxyl functionalities.
Keywords: Distributed Drug Discovery (D3); fundamental peptide scaffold; biomimetics; solid-phase organic synthesis; combinatorial chemistry Distributed Drug Discovery (D3); fundamental peptide scaffold; biomimetics; solid-phase organic synthesis; combinatorial chemistry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Scott, W.L.; Zhou, Z.; Zajdel, P.; Pawłowski, M.; O’Donnell, M.J. Solid-Phase Synthetic Route to Multiple Derivatives of a Fundamental Peptide Unit. Molecules 2010, 15, 4961-4983.

AMA Style

Scott WL, Zhou Z, Zajdel P, Pawłowski M, O’Donnell MJ. Solid-Phase Synthetic Route to Multiple Derivatives of a Fundamental Peptide Unit. Molecules. 2010; 15(7):4961-4983.

Chicago/Turabian Style

Scott, William L.; Zhou, Ziniu; Zajdel, Paweł; Pawłowski, Maciej; O’Donnell, Martin J. 2010. "Solid-Phase Synthetic Route to Multiple Derivatives of a Fundamental Peptide Unit." Molecules 15, no. 7: 4961-4983.


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