Special Issue "Chemical Protein and Peptide Synthesis"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 October 2012)
Prof. Dr. Fernando Albericio
1 Institute for Research in Biomedicine (IRB Barcelona), Parc Científic de Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain
2 School of Chemistry, University of KwaZulu-Natal, Durban 4001, South Africa
Phone: +34 93 403 70 88
Fax: +34 93 403 71 26
Interests: marine natural products; bioactive natural products; peptides; solid-phase chemistry; combinatorial chemistry; drug delivery systems
Dr. Thavi Govender
School of Pharmacy and Pharmacology, University of KwaZulu Natal Westville Campus, Durban 4000, South Africa
Interests: asymmetric catalysis; peptide chemistry and mass spectrometry
Today, almost hundred peptides and proteins are in the pharmaceutical world market, and much more are in several clinical phases. Although in the past the pharmaceutical industries had reduced their interest in peptide and protein research, the last decades they rekindled the interest in those chemical entities, due to novel strategy developments, advances in the areas of formulation, enhanced drug delivery technologies, and most importantly to the current chemical technological accomplishments. The objective of this Special Issue of Molecules is to highlight the last breakthroughs in the Chemical Synthesis of Peptides and Proteins.
Prof. Dr. Fernando Albericio
Dr. Thavi Govender
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs) and starting from 1 July 2012, it is 1600 CHF.
- convergent synthesis
- chemical ligation
- coupling reagent
- protecting group
- solid phase synthesis
- solid support
Review: Chemical Synthesis, Backbone Cyclization and Oxidative Folding of Cystine-knot Peptides — Promising Scaffolds for Applications in Drug Design
Molecules 2012, 17(11), 12533-12552; doi:10.3390/molecules171112533
Received: 15 August 2012; in revised form: 19 September 2012 / Accepted: 22 October 2012 / Published: 24 October 2012| Download PDF Full-text (496 KB) | Download XML Full-text
Molecules 2012, 17(12), 14230-14248; doi:10.3390/molecules171214230
Received: 8 October 2012; in revised form: 20 November 2012 / Accepted: 28 November 2012 / Published: 30 November 2012| Download PDF Full-text (768 KB) | Download XML Full-text
Molecules 2012, 17(12), 14361-14376; doi:10.3390/molecules171214361
Received: 22 October 2012; in revised form: 23 November 2012 / Accepted: 30 November 2012 / Published: 5 December 2012| Download PDF Full-text (333 KB)
Molecules 2013, 18(1), 287-310; doi:10.3390/molecules18010287
Received: 14 December 2012; in revised form: 19 December 2012 / Accepted: 19 December 2012 / Published: 27 December 2012| Download PDF Full-text (522 KB)
Molecules 2013, 18(1), 440-465; doi:10.3390/molecules18010440
Received: 28 November 2012; in revised form: 21 December 2012 / Accepted: 24 December 2012 / Published: 2 January 2013| Download PDF Full-text (1437 KB)
Review: Access to Any Site Directed Stable Isotope (2H, 13C, 15N, 17O and 18O) in Genetically Encoded Amino Acids
Molecules 2013, 18(1), 482-519; doi:10.3390/molecules18010482
Received: 25 October 2012; in revised form: 10 December 2012 / Accepted: 24 December 2012 / Published: 2 January 2013| Download PDF Full-text (474 KB)
Molecules 2013, 18(1), 1111-1121; doi:10.3390/molecules18011111
Received: 11 November 2012; in revised form: 10 January 2013 / Accepted: 10 January 2013 / Published: 16 January 2013| Download PDF Full-text (371 KB) |
Article: A Facile Synthesis of Fully Protected meso-Diaminopimelic Acid (DAP) and Its Application to the Preparation of Lipophilic N-Acyl iE-DAP
Molecules 2013, 18(1), 1162-1173; doi:10.3390/molecules18011162
Received: 5 December 2012; in revised form: 8 January 2013 / Accepted: 9 January 2013 / Published: 16 January 2013| Download PDF Full-text (269 KB)
Molecules 2013, 18(2), 1337-1367; doi:10.3390/molecules18021337
Received: 3 December 2012; in revised form: 14 January 2013 / Accepted: 16 January 2013 / Published: 24 January 2013| Download PDF Full-text (757 KB)
Review: 3-Substituted Prolines: From Synthesis to Structural Applications, from Peptides to Foldamers
Molecules 2013, 18(2), 2307-2327; doi:10.3390/molecules18022307
Received: 1 February 2013; in revised form: 5 February 2013 / Accepted: 6 February 2013 / Published: 19 February 2013| Download PDF Full-text (1038 KB)
Molecules 2013, 18(3), 3379-3409; doi:10.3390/molecules18033379
Received: 29 December 2012; in revised form: 25 February 2013 / Accepted: 7 March 2013 / Published: 14 March 2013| Download PDF Full-text (540 KB)
Review: Technologies for the Synthesis of mRNA-Encoding Libraries and Discovery of Bioactive Natural Product-Inspired Non-Traditional Macrocyclic Peptides
Molecules 2013, 18(3), 3502-3528; doi:10.3390/molecules18033502
Received: 31 January 2013; in revised form: 4 February 2013 / Accepted: 25 February 2013 / Published: 18 March 2013| Download PDF Full-text (1092 KB)
Article: Lanthanide-Mediated Dephosphorylation Used for Peptide Cleavage during Solid Phase Peptide Synthesis
Molecules 2013, 18(4), 3894-3905; doi:10.3390/molecules18043894
Received: 28 January 2013; in revised form: 27 February 2013 / Accepted: 27 March 2013 / Published: 2 April 2013| Download PDF Full-text (303 KB)
Molecules 2013, 18(4), 4373-4388; doi:10.3390/molecules18044373
Received: 12 March 2013; in revised form: 28 March 2013 / Accepted: 9 April 2013 / Published: 12 April 2013| Download PDF Full-text (408 KB)
Molecules 2013, 18(4), 4703-4717; doi:10.3390/molecules18044703
Received: 17 January 2013; in revised form: 10 April 2013 / Accepted: 17 April 2013 / Published: 19 April 2013| Download PDF Full-text (369 KB)
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products
Authors: Sara-Christina Stolze and Markus Kaiser
Affiliations: Zentrum für Medizinische Biotechnologie, Universität Duisburg-Essen, 45141 Essen, Germany
Abstract: Cyclodepsipeptide natural products often display potent biological activities which turn them into interesting targets for medicinal chemistry efforts. However, their often complex molecular structure frequently represents a challenge for chemical synthesis. In the present review, we will therefore present a selection of recent syntheses of cyclodepsipeptides with the aim to illustrate the synthetic challenges concealed in their molecular frameworks and to summarize methodologies that have evolved to overcome these challenges.
Type of Paper: Review
Title: Chemical Synthesis of Cystine Knots — A Promisinig Scaffold for Applications in Drug Design
Authors: Michael Reinwarth, Daichi Nasu,Harald Kolmar and Olga Avrutina
Affiliation: Institute for Organic Chemistry and Biochemistry, TU Darmstadt, Germany
Abstract: Cystine-knot peptides, so-called knottins, display exceptional structural, thermal, and biological stability. Their eponymous motif consists of six cysteine residues forming three disulfide bonds resulting in a notably rigid structural core. Since they highly tolerate either rational or combinatoric changes in their primary structure, cystine knots are considered to be promising frameworks for peptide-based pharmaceuticals. Although knottins are available /via/chemical and recombinant routes of synthesis, head-to-tail cyclization and oxidative folding towards the respecitve bioactive isomer still are the essential steps in synthesis. Herein we report the topology of cystine knots, their synthetical availability through sploid phase peptide synthesis including postsynthetic modifications as head-to-tail cyclization and oxidative folding. Finally we describe in short recent studies on biological activity using knottins with prescribed binding characteristics to target molecules of medical relevance.
Last update: 25 September 2012