Molecules 2010, 15(8), 5282-5335; doi:10.3390/molecules15085282
Review

Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives

1,2,* email and 1
Received: 4 June 2010; in revised form: 14 July 2010 / Accepted: 2 August 2010 / Published: 4 August 2010
(This article belongs to the Special Issue Solid Phase Synthesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Peptoids (N-substituted polyglycines and extended peptoids with variant backbone amino-acid monomer units) are oligomeric synthetic polymers that are becoming a valuable molecular tool in the biosciences. Of particular interest are their applications to the exploration of peptoid secondary structures and drug design. Major advantages of peptoids as research and pharmaceutical tools include the ease and economy of synthesis, highly variable backbone and side-chain chemistry possibilities. At the same time, peptoids have been demonstrated as highly active in biological systems while resistant to proteolytic decay. This review with 227 references considers the solid-phase synthetic aspects of peptoid preparation and utilization up to 2010 from the instigation, by R. N. Zuckermann et al., of peptoid chemistry in 1992.
Keywords: N-substituted polyglycine oligomer; peptoid; solid phase synthesis; synthetic methods
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MDPI and ACS Style

Culf, A.S.; Ouellette, R.J. Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives. Molecules 2010, 15, 5282-5335.

AMA Style

Culf AS, Ouellette RJ. Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives. Molecules. 2010; 15(8):5282-5335.

Chicago/Turabian Style

Culf, Adrian S.; Ouellette, Rodney J. 2010. "Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives." Molecules 15, no. 8: 5282-5335.

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