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Molecules 2009, 14(10), 3914-3921; doi:10.3390/molecules14103914
Article

Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker

,  and *
Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, Athens 15773, Greece
* Author to whom correspondence should be addressed.
Received: 8 September 2009 / Revised: 29 September 2009 / Accepted: 30 September 2009 / Published: 30 September 2009
(This article belongs to the Special Issue Solid Phase Synthesis)
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Abstract

An efficient three-step solid-phase synthesis of diverse 3,5-disubstituted-2-aminofuranones has been developed. α-Hydroxy acids loaded on a nitrophenyl carbonate derivative of Wang resin are used as acylating agents for the C-acylation of active methylene compounds and the resulting intermediates provided, through a cyclative cleavage reaction, the desired product.
Keywords: 2-aminofuranones; solid-phase synthesis; heterocycles; lactones; acylations 2-aminofuranones; solid-phase synthesis; heterocycles; lactones; acylations
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Matiadis, D.; Prousis, K.C.; Igglessi-Markopoulou, O. Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker. Molecules 2009, 14, 3914-3921.

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