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Molecules 2012, 17(5), 5467-5496; doi:10.3390/molecules17055467

Solid-Phase Parallel Synthesis of Drug-Like Artificial 2H-Benzopyran Libraries

1
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, 1370, Sangyuk-dong, Buk-gu, Daegu 702-701, Korea
2
Center for Innovative Drug Library Research, Department of Chemistry, College of Natural Science, Dongguk University-Seoul, 26 Pildong 3-ga, Jung-gu, Seoul 100-715, Korea
*
Author to whom correspondence should be addressed.
Received: 10 April 2012 / Revised: 25 April 2012 / Accepted: 7 May 2012 / Published: 9 May 2012
(This article belongs to the Special Issue Solid Phase Synthesis)
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Abstract

This review covers the construction of drug-like 2H-benzopyrans and related libraries using solid-phase parallel synthesis. In this context, the preparation of substituted benzopyrans such as mono-, di- and trisubstituted benzopyran derivatives and additional ring-fused benzopyrans such as benzopyranoisoxazoles, benzopyranopyrazoles, six-membered ring-fused benzopyrans, and polycyclic benzopyrans are highlighted.
Keywords: combinatorial chemistry; solid-phase synthesis; chemical library; drug-like molecules; 2H-benzopyran combinatorial chemistry; solid-phase synthesis; chemical library; drug-like molecules; 2H-benzopyran
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lee, T.; Gong, Y.-D. Solid-Phase Parallel Synthesis of Drug-Like Artificial 2H-Benzopyran Libraries. Molecules 2012, 17, 5467-5496.

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