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Solid-Phase Parallel Synthesis of Drug-Like Artificial 2H-Benzopyran Libraries
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, 1370, Sangyuk-dong, Buk-gu, Daegu 702-701, Korea
Center for Innovative Drug Library Research, Department of Chemistry, College of Natural Science, Dongguk University-Seoul, 26 Pildong 3-ga, Jung-gu, Seoul 100-715, Korea
* Author to whom correspondence should be addressed.
Received: 10 April 2012; in revised form: 25 April 2012 / Accepted: 7 May 2012 / Published: 9 May 2012
Abstract: This review covers the construction of drug-like 2H-benzopyrans and related libraries using solid-phase parallel synthesis. In this context, the preparation of substituted benzopyrans such as mono-, di- and trisubstituted benzopyran derivatives and additional ring-fused benzopyrans such as benzopyranoisoxazoles, benzopyranopyrazoles, six-membered ring-fused benzopyrans, and polycyclic benzopyrans are highlighted.
Keywords: combinatorial chemistry; solid-phase synthesis; chemical library; drug-like molecules; 2H-benzopyran
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MDPI and ACS Style
Lee, T.; Gong, Y.-D. Solid-Phase Parallel Synthesis of Drug-Like Artificial 2H-Benzopyran Libraries. Molecules 2012, 17, 5467-5496.
Lee T, Gong Y-D. Solid-Phase Parallel Synthesis of Drug-Like Artificial 2H-Benzopyran Libraries. Molecules. 2012; 17(5):5467-5496.
Lee, Taeho; Gong, Young-Dae. 2012. "Solid-Phase Parallel Synthesis of Drug-Like Artificial 2H-Benzopyran Libraries." Molecules 17, no. 5: 5467-5496.