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Molecules 2012, 17(5), 5467-5496; doi:10.3390/molecules17055467
Review

Solid-Phase Parallel Synthesis of Drug-Like Artificial 2H-Benzopyran Libraries

1
 and 2,*
1 Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, 1370, Sangyuk-dong, Buk-gu, Daegu 702-701, Korea 2 Center for Innovative Drug Library Research, Department of Chemistry, College of Natural Science, Dongguk University-Seoul, 26 Pildong 3-ga, Jung-gu, Seoul 100-715, Korea
* Author to whom correspondence should be addressed.
Received: 10 April 2012 / Revised: 25 April 2012 / Accepted: 7 May 2012 / Published: 9 May 2012
(This article belongs to the Special Issue Solid Phase Synthesis)
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Abstract

This review covers the construction of drug-like 2H-benzopyrans and related libraries using solid-phase parallel synthesis. In this context, the preparation of substituted benzopyrans such as mono-, di- and trisubstituted benzopyran derivatives and additional ring-fused benzopyrans such as benzopyranoisoxazoles, benzopyranopyrazoles, six-membered ring-fused benzopyrans, and polycyclic benzopyrans are highlighted.
Keywords: combinatorial chemistry; solid-phase synthesis; chemical library; drug-like molecules; 2H-benzopyran combinatorial chemistry; solid-phase synthesis; chemical library; drug-like molecules; 2H-benzopyran
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lee, T.; Gong, Y.-D. Solid-Phase Parallel Synthesis of Drug-Like Artificial 2H-Benzopyran Libraries. Molecules 2012, 17, 5467-5496.

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