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Molecules 2010, 15(7), 4924-4933; doi:10.3390/molecules15074924
Article

Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers

1, 1, 2, 2, 3,4,5, 6, 6 and 1,*
1 Instituto de Química Médica, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain 2 Combinatorial Chemistry Unit, Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain 3 Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain 4 CIBER-BBN, Networking Centre on Bioengineering Biomaterials and Nanomedicine, Barcelona 08028, Spain 5 Department of Organic Chemistry, University of Barcelona, Barcelona 08028, Spain 6 IBMC-UMH, Ed. Torregaitán, Av. de la Universidad s/n, 03202 Elche, Spain
* Author to whom correspondence should be addressed.
Received: 11 June 2010 / Revised: 14 July 2010 / Accepted: 15 July 2010 / Published: 15 July 2010
(This article belongs to the Special Issue Solid Phase Synthesis)
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Abstract

Trp(Nps)-Lys-NH2 derivatives, bearing alkyl or guanidine groups either at the N–terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists.
Keywords: solid-phase; Trp(Nps) dipeptides; TRPV1 channel blockers solid-phase; Trp(Nps) dipeptides; TRPV1 channel blockers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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De Vega, M.J.P.; García-López, M.T.; Zaccaro, L.; Royo, M.; Albericio, F.; Fernández-Carvajal, A.; Ferrer-Montiel, A.; González-Muñiz, R. Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers. Molecules 2010, 15, 4924-4933.

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