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Molecules 2010, 15(7), 4924-4933; doi:10.3390/molecules15074924
Article

Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers

1, 1, 2, 2, 3,4,5, 6, 6 and 1,*
Received: 11 June 2010 / Revised: 14 July 2010 / Accepted: 15 July 2010 / Published: 15 July 2010
(This article belongs to the Special Issue Solid Phase Synthesis)
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Abstract

Trp(Nps)-Lys-NH2 derivatives, bearing alkyl or guanidine groups either at the N–terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists.
Keywords: solid-phase; Trp(Nps) dipeptides; TRPV1 channel blockers solid-phase; Trp(Nps) dipeptides; TRPV1 channel blockers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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De Vega, M.J.P.; García-López, M.T.; Zaccaro, L.; Royo, M.; Albericio, F.; Fernández-Carvajal, A.; Ferrer-Montiel, A.; González-Muñiz, R. Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers. Molecules 2010, 15, 4924-4933.

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