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Molecules 2010, 15(7), 4924-4933; doi:10.3390/molecules15074924
Article

Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers

1, 1, 2, 2, 3,4,5, 6, 6 and 1,*
1 Instituto de Química Médica, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain 2 Combinatorial Chemistry Unit, Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain 3 Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain 4 CIBER-BBN, Networking Centre on Bioengineering Biomaterials and Nanomedicine, Barcelona 08028, Spain 5 Department of Organic Chemistry, University of Barcelona, Barcelona 08028, Spain 6 IBMC-UMH, Ed. Torregaitán, Av. de la Universidad s/n, 03202 Elche, Spain
* Author to whom correspondence should be addressed.
Received: 11 June 2010 / Revised: 14 July 2010 / Accepted: 15 July 2010 / Published: 15 July 2010
(This article belongs to the Special Issue Solid Phase Synthesis)
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Abstract

Trp(Nps)-Lys-NH2 derivatives, bearing alkyl or guanidine groups either at the N–terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists.
Keywords: solid-phase; Trp(Nps) dipeptides; TRPV1 channel blockers solid-phase; Trp(Nps) dipeptides; TRPV1 channel blockers
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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De Vega, M.J.P.; García-López, M.T.; Zaccaro, L.; Royo, M.; Albericio, F.; Fernández-Carvajal, A.; Ferrer-Montiel, A.; González-Muñiz, R. Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers. Molecules 2010, 15, 4924-4933.

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