Molecules 2010, 15(7), 4924-4933; doi:10.3390/molecules15074924
Article

Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers

Mª Jesús Pérez De Vega 1 , Mª Teresa García-López 1 , Laura Zaccaro 2 , Miriam Royo 2 , Fernando Albericio 3,4,5 , Asia Fernández-Carvajal 6 , Antonio Ferrer-Montiel 6  and Rosario González-Muñiz 1,* email
1 Instituto de Química Médica, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain 2 Combinatorial Chemistry Unit, Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain 3 Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain 4 CIBER-BBN, Networking Centre on Bioengineering Biomaterials and Nanomedicine, Barcelona 08028, Spain 5 Department of Organic Chemistry, University of Barcelona, Barcelona 08028, Spain 6 IBMC-UMH, Ed. Torregaitán, Av. de la Universidad s/n, 03202 Elche, Spain
* Author to whom correspondence should be addressed.
Received: 11 June 2010; in revised form: 14 July 2010 / Accepted: 15 July 2010 / Published: 15 July 2010
(This article belongs to the Special Issue Solid Phase Synthesis)
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Abstract: Trp(Nps)-Lys-NH2 derivatives, bearing alkyl or guanidine groups either at the N–terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists.
Keywords: solid-phase; Trp(Nps) dipeptides; TRPV1 channel blockers

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MDPI and ACS Style

De Vega, M.J.P.; García-López, M.T.; Zaccaro, L.; Royo, M.; Albericio, F.; Fernández-Carvajal, A.; Ferrer-Montiel, A.; González-Muñiz, R. Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers. Molecules 2010, 15, 4924-4933.

AMA Style

De Vega MJP, García-López MT, Zaccaro L, Royo M, Albericio F, Fernández-Carvajal A, Ferrer-Montiel A, González-Muñiz R. Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers. Molecules. 2010; 15(7):4924-4933.

Chicago/Turabian Style

De Vega, Mª Jesús Pérez; García-López, Mª Teresa; Zaccaro, Laura; Royo, Miriam; Albericio, Fernando; Fernández-Carvajal, Asia; Ferrer-Montiel, Antonio; González-Muñiz, Rosario. 2010. "Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers." Molecules 15, no. 7: 4924-4933.

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