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Synthesis of Peptide Radiopharmaceuticals for the Therapy and Diagnosis of Tumor Diseases
Department of Nuclear Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany
* Author to whom correspondence should be addressed.
Received: 29 December 2012; in revised form: 25 February 2013 / Accepted: 7 March 2013 / Published: 14 March 2013
Abstract: Despite the advances in molecular biology and biochemistry, the prognosis of patients suffering from tumor diseases remains poor. The limited therapeutic success can be explained by the insufficient performance of the common chemotherapeutic drugs that lack the ability to specifically target tumor tissues. Recently peptide radiopharmaceuticals have been developed that enable the concurrent imaging and therapy of tumors expressing a specific target. Here, with a special emphasis on the synthesis of the building blocks required for the complexation of metallic radioisotopes, the requirements to the design and synthesis of radiolabeled peptides for clinical applications are described.
Keywords: radionuclides; chelator; prosthetic groups; carrier molecules; peptides; medicinal application; radiopharmaceutical; diagnostic imaging; radiotherapeutics
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MDPI and ACS Style
Jamous, M.; Haberkorn, U.; Mier, W. Synthesis of Peptide Radiopharmaceuticals for the Therapy and Diagnosis of Tumor Diseases. Molecules 2013, 18, 3379-3409.
Jamous M, Haberkorn U, Mier W. Synthesis of Peptide Radiopharmaceuticals for the Therapy and Diagnosis of Tumor Diseases. Molecules. 2013; 18(3):3379-3409.
Jamous, Mazen; Haberkorn, Uwe; Mier, Walter. 2013. "Synthesis of Peptide Radiopharmaceuticals for the Therapy and Diagnosis of Tumor Diseases." Molecules 18, no. 3: 3379-3409.