Molecules 2012, 17(12), 14230-14248; doi:10.3390/molecules171214230
Article

Peptide-Based Selective Inhibitors of Matrix Metalloproteinase-Mediated Activities

1,2, 1, 1, 3,4 and 1,4,* email
Received: 8 October 2012; in revised form: 20 November 2012 / Accepted: 28 November 2012 / Published: 30 November 2012
(This article belongs to the Special Issue Chemical Protein and Peptide Synthesis)
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Abstract: The matrix metalloproteinases (MMPs) exhibit a broad array of activities, some catalytic and some non-catalytic in nature. An overall lack of selectivity has rendered small molecule, active site targeted MMP inhibitors problematic in execution. Inhibitors that favor few or individual members of the MMP family often take advantage of interactions outside the enzyme active site. We presently focus on peptide-based MMP inhibitors and probes that do not incorporate conventional Zn2+ binding groups. In some cases, these inhibitors and probes function by binding only secondary binding sites (exosites), while others bind both exosites and the active site. A myriad of MMP mediated-activities beyond selective catalysis can be inhibited by peptides, particularly cell adhesion, proliferation, motility, and invasion. Selective MMP binding peptides comprise highly customizable, unique imaging agents. Areas of needed improvement for MMP targeting peptides include binding affinity and stability.
Keywords: matrix metalloproteinase; protease inhibitor; secondary binding site; cyclic peptide; phage display; triple-helix
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ndinguri, M.W.; Bhowmick, M.; Tokmina-Roszyk, D.; Robichaud, T.K.; Fields, G.B. Peptide-Based Selective Inhibitors of Matrix Metalloproteinase-Mediated Activities. Molecules 2012, 17, 14230-14248.

AMA Style

Ndinguri MW, Bhowmick M, Tokmina-Roszyk D, Robichaud TK, Fields GB. Peptide-Based Selective Inhibitors of Matrix Metalloproteinase-Mediated Activities. Molecules. 2012; 17(12):14230-14248.

Chicago/Turabian Style

Ndinguri, Margaret W.; Bhowmick, Manishabrata; Tokmina-Roszyk, Dorota; Robichaud, Trista K.; Fields, Gregg B. 2012. "Peptide-Based Selective Inhibitors of Matrix Metalloproteinase-Mediated Activities." Molecules 17, no. 12: 14230-14248.


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