Molecules 2013, 18(2), 1337-1367; doi:10.3390/molecules18021337
Review

Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products

Zentrum für Medizinische Biotechnologie, Fakultät für Biologie, Universitätsstraße 2, 45117 Essen, Germany
* Author to whom correspondence should be addressed.
Received: 3 December 2012; in revised form: 14 January 2013 / Accepted: 16 January 2013 / Published: 24 January 2013
(This article belongs to the Special Issue Chemical Protein and Peptide Synthesis)
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Abstract: Cyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis. Although cyclodepsipeptides feature highly diverse chemical structures, their synthesis is often associated with similar synthetic challenges such as the establishment of a suitable macrocyclization methodology. This review therefore compiles case studies of synthetic approaches to different bioactive cyclodepsipeptide natural products, thereby illustrating obstacles of cyclodepsipeptide synthesis as well as their overcomings.
Keywords: cyclodepsipeptides; total synthesis; natural products; apratoxin A; spiruchostatin; FK228; ramoplanin; micropeptin T-20; Ahp-cyclodepsipeptide; symplocamide A

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MDPI and ACS Style

Stolze, S.C.; Kaiser, M. Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products. Molecules 2013, 18, 1337-1367.

AMA Style

Stolze SC, Kaiser M. Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products. Molecules. 2013; 18(2):1337-1367.

Chicago/Turabian Style

Stolze, Sara C.; Kaiser, Markus. 2013. "Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products." Molecules 18, no. 2: 1337-1367.

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