Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products

doi:10.3390/molecules18021337

This article is

freely available
re-usable

Molecules 2013, 18(2), 1337-1367; doi:10.3390/molecules18021337

Review

Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products

Sara C. Stolze and Markus Kaiser*

Zentrum für Medizinische Biotechnologie, Fakultät für Biologie, Universitätsstraße 2, 45117 Essen, Germany

* Author to whom correspondence should be addressed.

Received: 3 December 2012; in revised form: 14 January 2013 / Accepted: 16 January 2013 / Published: 24 January 2013

(This article belongs to the Special Issue Chemical Protein and Peptide Synthesis)

Download PDF Full-Text [757 KB, uploaded 24 January 2013 12:59 CET]

Abstract: Cyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis. Although cyclodepsipeptides feature highly diverse chemical structures, their synthesis is often associated with similar synthetic challenges such as the establishment of a suitable macrocyclization methodology. This review therefore compiles case studies of synthetic approaches to different bioactive cyclodepsipeptide natural products, thereby illustrating obstacles of cyclodepsipeptide synthesis as well as their overcomings.

Keywords: cyclodepsipeptides; total synthesis; natural products; apratoxin A; spiruchostatin; FK228; ramoplanin; micropeptin T-20; Ahp-cyclodepsipeptide; symplocamide A

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Stolze, S.C.; Kaiser, M. Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products. Molecules 2013, 18, 1337-1367.

AMA Style

Stolze SC, Kaiser M. Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products. Molecules. 2013; 18(2):1337-1367.

Chicago/Turabian Style

Stolze, Sara C.; Kaiser, Markus. 2013. "Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products." Molecules 18, no. 2: 1337-1367.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert