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Molecules 2013, 18(2), 1337-1367; doi:10.3390/molecules18021337
Review

Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products

 and *
Received: 3 December 2012 / Revised: 14 January 2013 / Accepted: 16 January 2013 / Published: 24 January 2013
(This article belongs to the Special Issue Chemical Protein and Peptide Synthesis)
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Abstract

Cyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis. Although cyclodepsipeptides feature highly diverse chemical structures, their synthesis is often associated with similar synthetic challenges such as the establishment of a suitable macrocyclization methodology. This review therefore compiles case studies of synthetic approaches to different bioactive cyclodepsipeptide natural products, thereby illustrating obstacles of cyclodepsipeptide synthesis as well as their overcomings.
Keywords: cyclodepsipeptides; total synthesis; natural products; apratoxin A; spiruchostatin; FK228; ramoplanin; micropeptin T-20; Ahp-cyclodepsipeptide; symplocamide A cyclodepsipeptides; total synthesis; natural products; apratoxin A; spiruchostatin; FK228; ramoplanin; micropeptin T-20; Ahp-cyclodepsipeptide; symplocamide A
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Stolze, S.C.; Kaiser, M. Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products. Molecules 2013, 18, 1337-1367.

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