Molecules 2012, 17(12), 14361-14376; doi:10.3390/molecules171214361
Article

Oxime-Based Carbonates as Useful Reagents for Both N-Protection and Peptide Coupling

Yahya El-Sayed Jad 1 , Sherine N. Khattab 1 , Ayman El-Faham 1,2,3,* email and Fernando Albericio 3,4,5,6,* email
1 Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, 21321 Alexandria, Egypt 2 Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, 11451 Riyadh, Saudi Arabia 3 Department of Chemistry and Molecular Pharmacology, Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028 Barcelona, Spain 4 CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028 Barcelona, Spain 5 Department of Organic Chemistry, University of Barcelona, Martí i Franqués 1-11, 08028 Barcelona, Spain 6 School of Chemistry, University of KwaZulu-Natal, 4041 Durban, South Africa
* Authors to whom correspondence should be addressed.
Received: 22 October 2012; in revised form: 23 November 2012 / Accepted: 30 November 2012 / Published: 5 December 2012
(This article belongs to the Special Issue Chemical Protein and Peptide Synthesis)
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Abstract: We have demonstrated that oxime-based mixed carbonates are very effective reagents for both N-protection and peptide coupling.
Keywords: oxime; additives; N-protection; activation; coupling; peptide

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Cite This Article

MDPI and ACS Style

Jad, Y.E.-S.; Khattab, S.N.; El-Faham, A.; Albericio, F. Oxime-Based Carbonates as Useful Reagents for Both N-Protection and Peptide Coupling. Molecules 2012, 17, 14361-14376.

AMA Style

Jad YE-S, Khattab SN, El-Faham A, Albericio F. Oxime-Based Carbonates as Useful Reagents for Both N-Protection and Peptide Coupling. Molecules. 2012; 17(12):14361-14376.

Chicago/Turabian Style

Jad, Yahya E.-S.; Khattab, Sherine N.; El-Faham, Ayman; Albericio, Fernando. 2012. "Oxime-Based Carbonates as Useful Reagents for Both N-Protection and Peptide Coupling." Molecules 17, no. 12: 14361-14376.

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