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Molecules 2012, 17(12), 14361-14376; doi:10.3390/molecules171214361
Article

Oxime-Based Carbonates as Useful Reagents for Both N-Protection and Peptide Coupling

1, 1, 1,2,3,*  and 3,4,5,6,*
1 Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, 21321 Alexandria, Egypt 2 Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, 11451 Riyadh, Saudi Arabia 3 Department of Chemistry and Molecular Pharmacology, Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028 Barcelona, Spain 4 CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028 Barcelona, Spain 5 Department of Organic Chemistry, University of Barcelona, Martí i Franqués 1-11, 08028 Barcelona, Spain 6 School of Chemistry, University of KwaZulu-Natal, 4041 Durban, South Africa
* Authors to whom correspondence should be addressed.
Received: 22 October 2012 / Revised: 23 November 2012 / Accepted: 30 November 2012 / Published: 5 December 2012
(This article belongs to the Special Issue Chemical Protein and Peptide Synthesis)
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Abstract

We have demonstrated that oxime-based mixed carbonates are very effective reagents for both N-protection and peptide coupling.
Keywords: oxime; additives; N-protection; activation; coupling; peptide oxime; additives; N-protection; activation; coupling; peptide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Jad, Y.E.-S.; Khattab, S.N.; El-Faham, A.; Albericio, F. Oxime-Based Carbonates as Useful Reagents for Both N-Protection and Peptide Coupling. Molecules 2012, 17, 14361-14376.

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