Special Issue "DNA Damage Response"

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A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (30 September 2012)

Special Issue Editors

Guest Editor
Prof. Dr. Wolf-Dietrich Heyer
Professor and Chair, Department of Microbiology & Molecular , University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
Website: http://micro.ucdavis.edu/heyer
E-Mail: wdheyer@ucdavis.edu
Phone: +1 530 752 3001
Fax: +1 530 752 3011
Interests: regulation and mechanisms of homologous recombination; genome stability; DNA damage response

Guest Editor
Prof. Dr. Thomas Helleday
Torsten and Ragnar Söderberg Professor of Translational Medicine Science for Life Laboratory, Division of Translational Medicine and Chemical Biology Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Box 1031, S-171 21 Stockholm, Sweden
Website: http://www.rob.ox.ac.uk/research/researchgroups/thomas-helleday
E-Mail: thomas.helleday@scilifelab.se
Phone: +46 8 524 815 30
Interests: DNA damage signalling; homologous recombination at replication forks in mammalian cells

Guest Editor
Prof. Dr. Fumio Hanaoka
Department of Life Science, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan
Website: http://www.jsps.go.jp/j-bilat/semin/gan_report/2000_cancer/hanaoka.html
E-Mail: fumio.hanaoka@gakushuin.ac.jp
Phone: +81 3 3986 0221 ext. 6457
Fax: +81 3 5992 1029
Interests: molecular mechanisms of translesion synthesis and nucleotide excision repair; understanding the cellular responses to DNA damages; interactions between cell cycle control and DNA repair

Special Issue Information

Dear Colleagues,

In two ground breaking publications in Science in 1988/1989, Ted Weinert and Lee Hartwell conceptualized many previous observations on how cells react to genotoxic stress by developing the checkpoint model. They validated the concept by isolating the first DNA damage checkpoint mutant in the budding yeast Saccharomyces cerevisiae and showing that RAD9 controlled transient cell cycle arrest after ionizing radiation exposure. These seminal discoveries propelled an entire field that is still thriving. We realize over 20 years later that the cell cycle response is only one, albeit critical aspect, of a much broader cellular answer to genotoxic stress that is now called the DNA Damage Response. This issue intends to showcase up to date reviews about emerging concepts from future leaders in this exciting area of research.

We thus invite submission review manuscripts (although original research manuscripts are welcome as well) that cover any aspect of the DNA damage response, a complex web of interconnected pathways that control many cellular processes including DNA replication, DNA repair, the mitotic and meiotic cell cycle, and nuclear architecture. The DNA damage response is intricately linked to cancer. Defects in the DNA damage response predispose humans to cancer, and many forms of anti-cancer treatment involve inducing localized or systemic DNA damage. Thus insights into the fundamental mechanisms of the DNA damage response are poised for translation into clinical practice.

We look forward to reading your contributions.

Prof. Dr. Wolf-Dietrich Heyer
Prof. Dr. Thomas Helleday
Prof. Dr. Fumio Hanaoka
Guest Editors

Keywords

  • DNA damage
  • DNA checkpoints
  • DNA repair
  • DNA replication
  • genome instability
  • heterochromatin
  • cell cycle control

Published Papers (11 papers)

by
Biomolecules 2013, 3(1), 75-84; doi:10.3390/biom3010075
Received: 3 December 2012; in revised form: 9 January 2013 / Accepted: 10 January 2013 / Published: 16 January 2013
Show/Hide Abstract | PDF Full-text (397 KB) | HTML Full-text | XML Full-text
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by  and
Biomolecules 2013, 3(1), 39-71; doi:10.3390/biom3010039
Received: 30 October 2012; in revised form: 11 December 2012 / Accepted: 11 December 2012 / Published: 27 December 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (829 KB) | HTML Full-text | XML Full-text

by , ,  and
Biomolecules 2013, 3(1), 1-17; doi:10.3390/biom3010001
Received: 24 October 2012; in revised form: 1 December 2012 / Accepted: 17 December 2012 / Published: 21 December 2012
Show/Hide Abstract | Cited by 6 | PDF Full-text (414 KB) | HTML Full-text | XML Full-text
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by  and
Biomolecules 2012, 2(4), 635-649; doi:10.3390/biom2040635
Received: 12 October 2012; in revised form: 29 November 2012 / Accepted: 9 December 2012 / Published: 14 December 2012
Show/Hide Abstract | Cited by 4 | PDF Full-text (455 KB) | HTML Full-text | XML Full-text
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by , , , ,  and
Biomolecules 2012, 2(4), 622-634; doi:10.3390/biom2040622
Received: 10 October 2012; in revised form: 30 November 2012 / Accepted: 3 December 2012 / Published: 14 December 2012
Show/Hide Abstract | PDF Full-text (358 KB) | HTML Full-text | XML Full-text
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by ,  and
Biomolecules 2012, 2(4), 579-607; doi:10.3390/biom2040579
Received: 17 October 2012; in revised form: 17 November 2012 / Accepted: 23 November 2012 / Published: 30 November 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (517 KB) | HTML Full-text | XML Full-textCorrection | Supplementary Files
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by , , ,  and
Biomolecules 2012, 2(4), 564-578; doi:10.3390/biom2040564
Received: 15 October 2012; in revised form: 7 November 2012 / Accepted: 9 November 2012 / Published: 15 November 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (833 KB) | HTML Full-text | XML Full-text
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by  and
Biomolecules 2012, 2(4), 524-548; doi:10.3390/biom2040524
Received: 18 September 2012; in revised form: 24 October 2012 / Accepted: 31 October 2012 / Published: 12 November 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (594 KB) | HTML Full-text | XML Full-text
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by , ,  and
Biomolecules 2012, 2(4), 505-523; doi:10.3390/biom2040505
Received: 10 September 2012; in revised form: 10 October 2012 / Accepted: 22 October 2012 / Published: 30 October 2012
Show/Hide Abstract | PDF Full-text (538 KB) | HTML Full-text | XML Full-text
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by ,  and
Biomolecules 2012, 2(4), 483-504; doi:10.3390/biom2040483
Received: 10 August 2012; in revised form: 5 October 2012 / Accepted: 8 October 2012 / Published: 16 October 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (642 KB) | HTML Full-text | XML Full-text

by ,  and
Biomolecules 2012, 2(3), 376-388; doi:10.3390/biom2030376
Received: 1 August 2012; in revised form: 23 August 2012 / Accepted: 24 August 2012 / Published: 4 September 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (680 KB) | HTML Full-text | XML Full-text
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Last update: 25 February 2014

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