Transcription Blockage Leads to New Beginnings
AbstractEnvironmental agents are constantly challenging cells by damaging DNA, leading to the blockage of transcription elongation. How do cells deal with transcription-blockage and how is transcription restarted after the blocking lesions are removed? Here we review the processes responsible for the removal of transcription-blocking lesions, as well as mechanisms of transcription restart. We also discuss recent data suggesting that blocked RNA polymerases may not resume transcription from the site of the lesion following its removal but, rather, are forced to start over from the beginning of genes. View Full-Text
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Andrade-Lima, L.C.; Veloso, A.; Ljungman, M. Transcription Blockage Leads to New Beginnings. Biomolecules 2015, 5, 1600-1617.
Andrade-Lima LC, Veloso A, Ljungman M. Transcription Blockage Leads to New Beginnings. Biomolecules. 2015; 5(3):1600-1617.Chicago/Turabian Style
Andrade-Lima, Leonardo C.; Veloso, Artur; Ljungman, Mats. 2015. "Transcription Blockage Leads to New Beginnings." Biomolecules 5, no. 3: 1600-1617.