Next Article in Journal
Chromatin Remodeling and Transcriptional Control in Innate Immunity: Emergence of Akirin2 as a Novel Player
Next Article in Special Issue
Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy
Previous Article in Journal
Functional Integration of mRNA Translational Control Programs
Previous Article in Special Issue
Protein Degradation Pathways Regulate the Functions of Helicases in the DNA Damage Response and Maintenance of Genomic Stability
Article Menu

Export Article

Open AccessReview
Biomolecules 2015, 5(3), 1600-1617; doi:10.3390/biom5031600

Transcription Blockage Leads to New Beginnings

1
Department of Radiation Oncology and Translational Oncology Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA
2
Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508-000, Brazil
3
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA
4
Novartis Institutes of Biomedical Sciences, Cambridge, MA 02139, USA
5
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Wolf-Dietrich Heyer, Thomas Helleday and Fumio Hanaoka
Received: 23 June 2015 / Revised: 9 July 2015 / Accepted: 16 July 2015 / Published: 21 July 2015
(This article belongs to the Special Issue DNA Damage Response)
View Full-Text   |   Download PDF [2071 KB, uploaded 21 July 2015]   |  

Abstract

Environmental agents are constantly challenging cells by damaging DNA, leading to the blockage of transcription elongation. How do cells deal with transcription-blockage and how is transcription restarted after the blocking lesions are removed? Here we review the processes responsible for the removal of transcription-blocking lesions, as well as mechanisms of transcription restart. We also discuss recent data suggesting that blocked RNA polymerases may not resume transcription from the site of the lesion following its removal but, rather, are forced to start over from the beginning of genes. View Full-Text
Keywords: DNA damage; DNA repair; RNA polymerase II; recovery of RNA synthesis DNA damage; DNA repair; RNA polymerase II; recovery of RNA synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Andrade-Lima, L.C.; Veloso, A.; Ljungman, M. Transcription Blockage Leads to New Beginnings. Biomolecules 2015, 5, 1600-1617.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top