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• Kousholt, ANedergaard
• Menzel, T
• Sørensen, CStorgaard
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• Kousholt, ANedergaard
• Menzel, T
• Sørensen, CStorgaard
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• Kousholt, ANedergaard
• Menzel, T
• Sørensen, CStorgaard

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Biomolecules 2012, 2(4), 579-607; doi:10.3390/biom2040579

Review

Pathways for Genome Integrity in G2 Phase of the Cell Cycle

Arne Nedergaard Kousholt ^† , Tobias Menzel ^†  and Claus Storgaard Sørensen*

Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark ^† These authors contributed equally to this work.

* Author to whom correspondence should be addressed.

Received: 17 October 2012; in revised form: 17 November 2012 / Accepted: 23 November 2012 / Published: 30 November 2012

(This article belongs to the Special Issue DNA Damage Response)

Download PDF Full-Text [517 KB, Updated Version, uploaded 3 December 2012 14:49 CET]

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Abstract: The maintenance of genome integrity is important for normal cellular functions, organism development and the prevention of diseases, such as cancer. Cellular pathways respond immediately to DNA breaks leading to the initiation of a multi-facetted DNA damage response, which leads to DNA repair and cell cycle arrest. Cell cycle checkpoints provide the cell time to complete replication and repair the DNA damage before it can continue to the next cell cycle phase. The G2/M checkpoint plays an especially important role in ensuring the propagation of error-free copies of the genome to each daughter cell. Here, we review recent progress in our understanding of DNA repair and checkpoint pathways in late S and G2 phases. This review will first describe the current understanding of normal cell cycle progression through G2 phase to mitosis. It will also discuss the DNA damage response including cell cycle checkpoint control and DNA double-strand break repair. Finally, we discuss the emerging concept that DNA repair pathways play a major role in the G2/M checkpoint pathway thereby blocking cell division as long as DNA lesions are present.

Keywords: genome integrity; IR; DNA damage checkpoint; G2/M transition; DNA repair

Correction

• Correction

  A correction was published on 15 January 2013: http://www.mdpi.com/2218-273X/3/1/72 (PDF, 330 KB)

  We have discovered an error in our paper published in Biomolecules [1], in Figure 1 on page 589. The protein names ATR and ATRIP have been swapped. A corrected version of the Figure 1 is provided below.

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