Next Article in Journal
Binding of Sperm to the Zona Pellucida Mediated by Sperm Carbohydrate-Binding Proteins is not Species-Specific in Vitro between Pigs and Cattle
Next Article in Special Issue
Protein Degradation Pathways Regulate the Functions of Helicases in the DNA Damage Response and Maintenance of Genomic Stability
Previous Article in Journal
Correction: Kousholt, A.N. et al. Pathways for Genome Integrity in G2 Phase of the Cell Cycle. Biomolecules 2012, 2, 579-607
Previous Article in Special Issue
Homologous Recombination as a Replication Fork Escort: Fork-Protection and Recovery
Article Menu

Export Article

Open AccessReview
Biomolecules 2013, 3(1), 75-84; doi:10.3390/biom3010075

Role of the Checkpoint Clamp in DNA Damage Response

Department of Radiation Oncology, Johns Hopkins University, School of Medicine, Baltimore MD 21231, USA
Received: 3 December 2012 / Revised: 9 January 2013 / Accepted: 10 January 2013 / Published: 16 January 2013
(This article belongs to the Special Issue DNA Damage Response)
View Full-Text   |   Download PDF [397 KB, uploaded 16 January 2013]   |  

Abstract

DNA damage occurs during DNA replication, spontaneous chemical reactions, and assaults by external or metabolism-derived agents. Therefore, all living cells must constantly contend with DNA damage. Cells protect themselves from these genotoxic stresses by activating the DNA damage checkpoint and DNA repair pathways. Coordination of these pathways requires tight regulation in order to prevent genomic instability. The checkpoint clamp complex consists of Rad9, Rad1 and Hus1 proteins, and is often called the 9-1-1 complex. This PCNA (proliferating cell nuclear antigen)-like donut-shaped protein complex is a checkpoint sensor protein that is recruited to DNA damage sites during the early stage of the response, and is required for checkpoint activation. As PCNA is required for multiple pathways of DNA metabolism, the checkpoint clamp has also been implicated in direct roles in DNA repair, as well as in coordination of the pathways. Here we discuss roles of the checkpoint clamp in DNA damage response (DDR). View Full-Text
Keywords: DNA damage checkpoint; checkpoint clamp; DNA repair; Rad9 DNA damage checkpoint; checkpoint clamp; DNA repair; Rad9
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kai, M. Role of the Checkpoint Clamp in DNA Damage Response. Biomolecules 2013, 3, 75-84.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top