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Sumoylation and the DNA Damage Response
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
Programs in Biochemistry, Cell, and Molecular Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA
Current address: Mammalian Genetics Lab, Cancer Research UK London Research Institute, London WC2A 3LY, UK
* Author to whom correspondence should be addressed.
Received: 1 August 2012; in revised form: 23 August 2012 / Accepted: 24 August 2012 / Published: 4 September 2012
Abstract: The cellular response to DNA damage involves multiple pathways that work together to promote survival in the face of increased genotoxic lesions. Proteins in these pathways are often posttranslationally modified, either by small groups such as phosphate, or by protein modifiers such as ubiquitin or SUMO. The recent discovery of many more SUMO substrates that are modified at higher levels in damage conditions adds weight to the accumulated evidence suggesting that sumoylation plays an important functional role in the DNA damage response. Here we discuss the significance of DNA damage-induced sumoylation, the effects of sumoylation on repair proteins, sumoylation dynamics, and crosstalk with other posttranslational modifications in the DNA damage response.
Keywords: sumoylation; DNA damage response; genome integrity
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Cite This Article
MDPI and ACS Style
Cremona, C.A.; Sarangi, P.; Zhao, X. Sumoylation and the DNA Damage Response. Biomolecules 2012, 2, 376-388.
Cremona CA, Sarangi P, Zhao X. Sumoylation and the DNA Damage Response. Biomolecules. 2012; 2(3):376-388.
Cremona, Catherine A.; Sarangi, Prabha; Zhao, Xiaolan. 2012. "Sumoylation and the DNA Damage Response." Biomolecules 2, no. 3: 376-388.