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Biomolecules 2015, 5(4), 2935-2977; doi:10.3390/biom5042935

The RNA Splicing Response to DNA Damage

Microbiologie et d’Infectiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada
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Academic Editors: Wolf-Dietrich Heyer, Thomas Helleday and Fumio Hanaoka
Received: 12 August 2015 / Revised: 20 September 2015 / Accepted: 16 October 2015 / Published: 29 October 2015
(This article belongs to the Special Issue DNA Damage Response)
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Abstract

The number of factors known to participate in the DNA damage response (DDR) has expanded considerably in recent years to include splicing and alternative splicing factors. While the binding of splicing proteins and ribonucleoprotein complexes to nascent transcripts prevents genomic instability by deterring the formation of RNA/DNA duplexes, splicing factors are also recruited to, or removed from, sites of DNA damage. The first steps of the DDR promote the post-translational modification of splicing factors to affect their localization and activity, while more downstream DDR events alter their expression. Although descriptions of molecular mechanisms remain limited, an emerging trend is that DNA damage disrupts the coupling of constitutive and alternative splicing with the transcription of genes involved in DNA repair, cell-cycle control and apoptosis. A better understanding of how changes in splice site selection are integrated into the DDR may provide new avenues to combat cancer and delay aging. View Full-Text
Keywords: DNA damage response; R-loops; RNA binding proteins; pre-mRNA; splicing factors; alternative splicing; splice site selection; chromatin; transcription; signal transduction DNA damage response; R-loops; RNA binding proteins; pre-mRNA; splicing factors; alternative splicing; splice site selection; chromatin; transcription; signal transduction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Shkreta, L.; Chabot, B. The RNA Splicing Response to DNA Damage. Biomolecules 2015, 5, 2935-2977.

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