Next Article in Journal / Special Issue
Diversity of Endonuclease V: From DNA Repair to RNA Editing
Previous Article in Journal
Uncommon Glycosidases for the Enzymatic Preparation of Glycosides
Previous Article in Special Issue
Managing Single-Stranded DNA during Replication Stress in Fission Yeast
Article Menu

Export Article

Open AccessReview
Biomolecules 2015, 5(4), 2184-2193; doi:10.3390/biom5042184

Arsenic Disruption of DNA Damage Responses—Potential Role in Carcinogenesis and Chemotherapy

1
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
2
Departments of Radiation Oncology and Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109-2800, USA
3
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Wolf-Dietrich Heyer, Thomas Helleday and Fumio Hanaoka
Received: 14 August 2015 / Revised: 6 September 2015 / Accepted: 9 September 2015 / Published: 24 September 2015
(This article belongs to the Special Issue DNA Damage Response)
View Full-Text   |   Download PDF [426 KB, uploaded 24 September 2015]   |  

Abstract

Arsenic is a Class I human carcinogen and is widespread in the environment. Chronic arsenic exposure causes cancer in skin, lung and bladder, as well as in other organs. Paradoxically, arsenic also is a potent chemotherapeutic against acute promyelocytic leukemia and can potentiate the cytotoxic effects of DNA damaging chemotherapeutics, such as cisplatin, in vitro. Arsenic has long been implicated in DNA repair inhibition, cell cycle disruption, and ubiquitination dysregulation, all negatively impacting the DNA damage response and potentially contributing to both the carcinogenic and chemotherapeutic potential of arsenic. Recent studies have provided mechanistic insights into how arsenic interferes with these processes including disruption of zinc fingers and suppression of gene expression. This review discusses these effects of arsenic with a view toward understanding the impact on the DNA damage response. View Full-Text
Keywords: arsenic; DNA repair; DNA damage response; ubiquitination; XPC; MSH2 arsenic; DNA repair; DNA damage response; ubiquitination; XPC; MSH2
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Muenyi, C.S.; Ljungman, M.; States, J.C. Arsenic Disruption of DNA Damage Responses—Potential Role in Carcinogenesis and Chemotherapy. Biomolecules 2015, 5, 2184-2193.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top