2,087,725 Results Found

Lysine deacetylases (KDACs) are central regulators of chromatin organization, transcription, metabolism, DNA repair, and cellular signaling, yet their molecular and clinical landscape across human cancers has not been systematically defined. Here, we...

Security control assessment under a risk management framework (RMF) is performed by a socio-technical system of assessors, procedures, and tools, so deciding where to automate it is a resource-allocation problem. This study proposes a Delphi–AH...

Background: KRAS mutations occur in over 90% of pancreatic ductal adenocarcinomas (PDAC), and KRASG12D is the most frequent variant. G12D-selective inhibitors are now in clinical development, but computational pathology has so far predicted mutation...

With the rapid advancement of AI-generated content (AIGC) technologies, novel attack paradigms such as image generative tampering and resampling have posed severe challenges to existing robust watermarking algorithms. Current deep learning-based wate...

Background and Objective: Sarcopenic obesity (SO) may contribute to cognitive decline through mechanisms involving the muscle–brain axis. Brain-derived neurotrophic factor (BDNF) and amyloid-β are potential biomarkers linking muscle health...

Faba bean is a promising substrate for tempeh-like products, although its sensory characteristics and the presence of compounds such as vicine, convicine and L-DOPA may limit its wider use. This study investigated whether ozone pretreatment modifies...

This paper qualitatively examines the intersectional precarity experienced by Zimbabwean immigrants in South Africa and its severe impact on transnational care economies, family separation, and cross-border kinship bonds. This study uses a decolonial...

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) and atherosclerosis often occur together and share the same metabolic risk factors. The aim of our study was to assess the prevalence of MASLD and factors associa...

Roadside units that combine a millimetre-wave radar with a camera are becoming part of the road infrastructure, and using the two sensors together requires their extrinsic calibration. Above live lanes a target-based calibration is costly and has to...

This paper develops a High-Frequency Economic Index (HFEI) for Ecuador using a Bayesian dynamic factor model estimated with weekly, monthly, and quarterly official indicators. A pseudo-week structure harmonizes the timing of observations and their ag...

Vegetative propagation from cuttings is a critical horticultural stage, and controlled environments allow regulation of the conditions that affect rooting. This review analyzes how cutting-propagation technologies are studied, protected, and commerci...

Blue phases are characterized by three-dimensional periodic structures self-assembling in chiral nematic—cholesteric liquid crystals (CLCs). They paradoxically combine the fluidity of liquids with the elasticity of crystalline solids. We develo...

Config-driven user interface (CDUI), also called server-driven user interface, moves user interface (UI) layout out of the app binary into server responses so teams can update screens without an app store release. Because one schema serves many insta...

Ergonomically unfavorable postures remain a major risk factor for work-related musculoskeletal disorders (WRMSDs) among ultrasound operators. Dermatologic and facial ultrasound presents specific ergonomic challenges because it requires delicate trans...

Secure image transmission requires encryption schemes with strong diffusion capability, high key sensitivity, and reliable reversibility. This paper designs a color image encryption framework based on a fractional-order Chua system and a matrix semi-...

Objectives: To examine whether sex modifies associations between whole-night and sleep-stage-specific respiratory indices and metabolic parameters in children with obstructive sleep apnea (OSA). Methods: This retrospective cross-sectional secondary a...

Identifying non-linear evolutionary patterns within the water–society–economy–ecology (WSEE) system is fundamental for sustainable development research in arid regions. Taking the Ji-shaped bend of the Yellow River as a case study,...

The long-term stability of brain–computer interface (BCI) electrodes depends not only on the quality of neural signal acquisition but also on mechanical mismatch at the electrode–neural tissue interface, chronic inflammation, glial scarri...

This study proposes the innovative “GIS–Generalized Symmetric Structural Graph” Framework for Restaurant Differentiation (GGSF), integrating GIS spatial analysis with generalized symmetric structural graphs. Taking Changsha’s...

Environmental pollution represents a critical factor influencing the structure, dynamics, and long-term sustainability of ecological systems. This study develops a nonlinear mathematical model that describes the interactions between three biological...

The increasing presence of artificial intelligence (AI) in competitive environments raises questions about whether perceived opponent identity influences individuals’ willingness to enter competitions. This study investigates whether framing op...

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects over 16% of the global population, and its progression to steatohepatitis (MASH) increases the risk of cirrhosis and hepatocellular carcinoma. Long non-coding RNAs (lncRNAs) hav...

Cardiovascular–Kidney–Metabolic (CKM) syndrome, a term introduced by the American Heart Association (AHA) in 2023, reflects the growing recognition of how metabolic dysfunction drives multi-organ pathology through interconnected pathways....

Fresh concrete filling height is difficult to monitor in formwork where direct observation is limited. This study develops a contact-activated U-shaped carbon nanotube/epoxy (CNT/EP) composite sensor for real-time monitoring of this height. Its heigh...

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation therapy with established evidence in the treatment of depression. Despite its clinical use, the mechanism(s) underlying the therapeutic effects of rTMS for depress...

Ichthyophthirius multifiliis is an obligate parasitic ciliate that causes white spot disease in freshwater fish. Its mitochondrial genome has been represented by a single linear sequence from strain G5, leaving variation among isolates largely unexpl...

Postmenopausal osteoporosis (PMO) caused by estrogen deficiency remains a major global health challenge, yet safe and effective nutritional strategies to alleviate its associated bone loss are limited. Here we developed two synbiotic yogurt formulati...

Stress-related proteins are overexpressed in plants under adverse growth conditions, helping them to survive. The identification and quantification of these proteins are limited in non-model organisms. Furthermore, the high concentration of storage p...

Anaplasma spp. are tick-borne zoonotic pathogens, but their molecular detection frequency and clinical sinificance in domestic cats in urban China remain largely unknown. To address this gap, we investigated Anaplasma infection in cats from Zhengzhou...

Assessing heavy metals in vegetables obtained from retail markets is essential, as it reflects actual human consumption and serves as the final safeguard for public food safety. Therefore, this study aimed to measure the concentrations of the followi...

Brassica juncea (Indian mustard) is an economically important oilseed crop, but high erucic acid in traditional seed oils and elevated glucosinolates in seed meal remain important quality-improvement targets. Its allotetraploid genome, developmental...

Ochroma lagopus is the lightest wood species in the world and is typically limited by nitrogen availability during its growth. To reveal the “carbon–nutrient” adaptation mechanism of this fast-growing tree species to different nitro...

Background/Objectives: BMI does not capture prior weight trajectory. We assessed whether historical weight difference from self-reported lifetime maximum weight and erythrocyte sedimentation rate (ESR) were associated with all-cause mortality in type...

Oxidative stress has traditionally been viewed as an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, leading to cellular damage and disease progression. However, the failure of conventional antioxidant therapies i...

Vehicle detection in satellite videos is challenging because of the small size of vehicles, low contrast, and complex backgrounds. In sparse detectors trained with center-based supervision, output nodes may be present within a vehicle’s boundin...

Racetams are structurally related but pharmacologically heterogeneous compounds studied in relation to cognition. This narrative and critical review compares piracetam, aniracetam, oxiracetam, pramiracetam, phenylpiracetam, fasoracetam, and levetirac...

Accurate mapping of small wetlands remains challenging due to their limited spatial extent, fragmented boundaries, and spectral similarity to surrounding land-cover types. To address these challenges, this study proposes RSF-HG-BDResUNet, a deep lear...

Some edible oils are produced by heterotrophic fermentation of Prototheca, a genus of non-photosynthetic green algae. Two accessions from the University of Texas Culture Collection of Algae (UTEX) have been used for oil production: UTEX 1435 historic...

This study analyzes the autocovariance function of a binary sequence generated by switching between two stationary binary source sequences according to a third binary control sequence. Assuming that the three component sequences are mutually statisti...

Trait emotional intelligence (trait EI) is relevant to children’s emotional and social functioning, yet its psychometric organization and its position within the broader school context remain incompletely understood during middle childhood. The...

Background/Objectives: Vaccination is a key public health intervention for preventing vaccine-preventable diseases among adults aged 65 years and older. In Australia, five vaccines are currently recommended and funded for older adults: COVID-19, infl...

Cancer vaccines can generate durable, tumor-specific T-cell responses, yet immunogenicity remains an imperfect surrogate for tumor control. An important, incompletely characterized contributor may be the metabolic fitness of the vaccine-induced immun...

Artificial lighting offers a practical method for regulating plant growth and nutritional content. This study examined how LED light quality, intensity, and exposure duration affect S. oleracea growth and individual flavonoid accumulation. After 4 we...

Background/Objectives: Psoriasis is a common chronic inflammatory skin disorder, affecting approximately 0.6–1.1% of adults worldwide. Guselkumab, a selective interleukin (IL)-23 inhibitor, is highly effective in moderate-to-severe plaque psori...

This work examines the acoustic modelling and design of Helmholtz resonators (HRs) for the noise in a shop-floor cabin housing a friction stir processing (FSP) machine, whose spectrum has a dominant tone at 470 Hz. The main contribution lies in the m...

A subtilisin-like protease from Solanum elaeagnifolium (Sela-SP1) was partially purified using a chromatography protocol combining IEC, HIC, and SEC. Sela-SP1 exhibited an apparent molecular mass of 70 kDa, and its activity was inhibited by the serin...

Inherited cancer susceptibility and tumor microevolution concern different levels of cancer biology. This critical narrative review examines their connections in gastric, colorectal, hepatocellular, biliary tract and pancreatic cancers. We organize t...

As a major toxic component of environmental fine particulate matter (PM_2.5), polycyclic aromatic hydrocarbons (PAHs) pose a significant risk to human health, particularly for liver damage, following inhalation or ingestion. However, their comprehensi...

Mikania micrantha is a globally destructive invasive weed, and the botanical herbicide 4-O-α-thevetopyranosyldiphyllin exhibits potent activity against it. We previously showed that this compound downregulated seven photosynthetic genes (PsaA, ...

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder driven by abnormal interactions between fibroblast-like synoviocytes (RA-FLSs) and synovial macrophages, leading to sustained synovitis. Although transcriptomic evidence reveals...