2,059,930 Results Found

Class imbalance remains a central problem in machine learning because the rare class is often the event of scientific, clinical, financial, or operational interest. Yet the literature is fragmented across sampling, cost-sensitive learning, ensembles,...

S-adenosylmethionine (SAMe) depletion may represent a rate-limiting nexus linking oxidative/nitrosative stress to epigenetic failure during neurulation. In this review, we synthesize evidence that diverse teratogenic and metabolic insults, including...

mRNA vaccines have emerged as a promising platform in vaccinology, enabling rapid and flexible antigen design. By delivering mRNA encoding target antigens, they allow in situ protein expression and induction of adaptive immune responses. Advances in...

The large-scale integration of offshore wind power increases the flexibility requirements of the integrated power grid. To address this issue, a low-carbon dispatch strategy is proposed for an offshore-wind-integrated electricity–gas–meth...

We present a generalized electrostatic SWAP gate realized in a chain of two double quantum dots operated in the single-electron regime. Using a minimalist tight-binding model, we derive analytical results and corroborate them with numerical simulatio...

Because of the adverse ecological impact of rapid urbanization, coupling the study of urban land use efficiency (ULUE) and ecological carrying capacity (ECC) is vital for harmonizing socioeconomic growth and environmental protection, and promoting re...

Electroencephalography (EEG) is a cost-effective and noninvasive modality for identifying neurophysiological alterations associated with Alzheimer’s disease (AD). To robustly extract disease-specific features, this study presents contrastive mu...

Crude petroleum oil (CPO), acting as an abiotic soil factor, significantly influences the chemical properties of tropical riverine mangrove roots; however, there has been a lack of systematic explanation regarding the effects of varying concentration...

Aortic aneurysms are associated with substantial morbidity and mortalitbecause of the risk of progressive dilation, rupture, and related acute aortic complications. Although diabetes mellitus (DM) is a major cardiovascular risk factor, epidemiologica...

Museum digitalization is often evaluated through adoption, satisfaction, or operational efficiency, while its relationship to cultural sustainability is less clearly specified. This study examines the association between museum digital service qualit...

Mamba has recently become a popular visual representation architecture for building change detection (BCD) in the remote sensing field. Although it effectively models global spatial dependencies, it still struggles to capture fine-grained local struc...

The nonlinear interaction between storm surge and astronomical tide controls coastal flood levels in macrotidal regions, but the effect of tidal phase on the surge of a given typhoon is rarely quantified. Using a high-resolution MIKE 21 FM model of t...

Objectives: Epidemiological surveys in rural China have reported comparatively high adolescent self-harm rates. Evidence on how peer relationships and father involvement jointly relate to this risk and on whether depression or anxiety helps to explai...

This study presents a practical approach to developing a prototype outdoor cleaning robot with reduced hardware and software complexity. While indoor cleaning robots are widely adopted, their outdoor counterparts remain costly and less accessible due...

Rapid landslide mapping is important for disaster response, yet modern segmentation networks can require substantial computation and storage. This study proposes Geography-, Boundary-, and Scar-Aware Structured Pruning (GeoBASP) for compact landslide...

Background/Objectives. Although onabotulinumtoxinA (BoNTA) is an established therapy for chronic migraine (CM), its effectiveness in high-frequency episodic migraine (HFEM) remains uncertain. We conducted an 18-year, single-center, retrospective stud...

PSY is a three-herb formula comprising Patriniae Radix, Mori Cortex Radicis, and Coix Seed that was previously shown to inhibit STAT3 signaling in colorectal cancer (CRC) cells. Here, we investigated molecular and metabolic responses to PSY, its anti...

The transition from peat-based to sustainable, compost-based growing media represents a critical challenge and opportunity in modern organic horticulture. This review comprehensively analyzes the theoretical frameworks, methodological approaches, and...

Rapid encroachment of edge and bottom water in ultra-deep gas reservoirs often leads to water breakthrough in gas wells and productivity decline, which has become a major engineering issue restricting the long-term stable development of the Keshen Bl...

This paper presents a circular ultra-thin vapor chamber (UTVC) with a thickness of 1.3 mm for LED lamp thermal management. Superhydrophilic patterned microstructure (SPMS) arrays are fabricated on the upper and bottom covers to replace the traditiona...

Large gravity anchorages founded on soft marine deposits often rely on partial cement-based ground improvement, creating a composite-foundation base in which treated area and mechanical contribution are not equivalent. This study develops a normal-lo...

Frictional finite-element solves of spur-gear tooth stress take tens of seconds. A ten-member Fourier neural operator (FNO) ensemble, trained on 270 of 432 quasi-static plane-strain solutions with Coulomb friction in the single-tooth contact zone, pr...

Forest resources are globally valuable and critical in many ecological processes. The forest canopy remote sensing model is an essential tool for understanding forest growth conditions. Over time, the model has evolved to consider the effects of the...

The fire safety of lithium-ion battery systems in electric vehicles is often examined through separate studies of thermal runaway, propagation, early warning, and fire suppression, making it difficult to translate fragmented evidence into system-leve...

Acute heat exposure challenges honey bee (Apis mellifera) workers, yet the associated small-molecule response and its relationship to nutritional status remain incompletely resolved. Workers were conditioned for 7 days on bee bread plus sucrose (B+S)...

Urban shrinkage causes inefficient land utilization and landscape fragmentation. Green spaces are critical nature-based solutions for the sustainable development of shrinking cities, and play an important role in enhancing urban environmental quality...

Driven by the digital economy, a new model of activities that integrates online and offline elements is reshaping the spatial patterns of urban vitality. Taking the central urban area of Changsha as the study region, this paper constructs an evaluati...

Styrene–acrylic elastomeric waterproofing membranes are widely used in exterior construction because of their flexibility, adhesion, and ease of application; however, their long-term performance depends on resistance to environmental aging and...

Whole black wheat increases the dietary fiber and anthocyanin content of bread, but reduces loaf-specific volume and increases crumb firmness. This study evaluated Cili (Rosa roxburghii Tratt.) fruit co-culture fermented with Bacillus subtilis and La...

This paper presents the design and preliminary mechanical validation of a bistable switching module driven by shape memory alloy (SMA) springs for CubeSat reflector-panel applications. A pre-compressed curved compliant beam provides passive state ret...

Although acute aerobic exercise selectively influences specific subcomponents of working memory, whether such benefits transfer to a subsequent cognitive task engaging a different domain remains unclear. Forty-seven participants completed, in randomi...

Preclinical drug development suffers from a persistent translational gap, as conventional animal models fail to reproduce the human immune response, contributing to high attrition rates of drug candidates in clinical trials. To address this, we previ...

Grass carp hemorrhagic disease (GCHD) induced by grass carp reovirus (GCRV) causes severe economic losses in the grass carp aquaculture industry, and breeding for GCRV resistance is of great significance for disease prevention and genetic improvement...

Intertidal red algae show much stronger tolerance to hypersaline stress than terrestrial plants. However, the characteristics of Ca²⁺ signaling and the SOS-related ion regulatory mechanisms involved in their hypersaline stress responses remain unclea...

The transition from conventional manufacturing processes to flexible production systems represents a key enabler for improving adaptability for faster product change and therefore manufacturing efficiency. However, the increased complexity of such ma...

Wild canids inhabiting anthropized landscapes can act as environmental indicators and potential reservoirs of zoonotic parasites, connecting transmission cycles among wild, domestic, and human hosts. We aimed to identify and characterize helminths in...

Zoology has entered an era in which molecular approaches are no longer ancillary tools, but central components to grasp animal diversity, evolution, physiology, adaptation, and conservation [...]

Immune imprinting shapes every subsequent response to antigenically related pathogens and is now central to designing updated vaccines for influenza, SARS-CoV-2, and respiratory syncytial virus (RSV). The label “Original Antigenic Sin” ha...

Land subsidence is a geohazard in groundwater-dependent regions, requiring assessment to support hazard mitigation and regional planning. This study presents an integrated framework combining Sentinel-1 deformation monitoring and machine learning-bas...

Background: Erythrocyte proteins released into plasma carry oxidation-related annotations and can be read as evidence of oxidative stress. We examined whether this applies to an oxidative-stress enrichment reported in a plasma proteomic study of obst...

Cancer cells hijack RNA metabolism, including splicing, polyadenylation, nuclear export and translation, to change both the amount and the form of the proteins they produce. This creates therapeutic vulnerabilities beyond the mutations and translocat...

Background/Objectives: Sustained drug-free status is an emerging milestone after atezolizumab plus bevacizumab for unresectable hepatocellular carcinoma. We examined baseline host biomarkers associated with achievement of 6-month sustained drug-free...

Noise-induced spectral fluctuations can substantially degrade gas concentration retrieval in tunable diode laser absorption spectroscopy (TDLAS), particularly when the absorption features are weak. A coordinate-attention-enhanced convolutional neural...

Background/Objectives: Phenoconversion extends pharmacogenomics beyond genetic variation by accounting for non-genetic factors that can also dynamically alter metabolism, influence treatment response, adverse effect risk and overall patient outcomes....

Background/Objectives: Pharmacovigilance studies typically evaluate adverse events as isolated drug–event pairs, potentially overlooking symptoms and functional impairments reported concurrently within the same case. We investigated co-reported...

Piezoelectric braided cords composed of poly-L-lactic acid (PLLA) fibers can be integrated into textiles to detect mechanical signals without requiring sensors to be attached directly to the body. In this study, we investigated the potential of a bed...

Most spoken word recognition models assume that a target word co-activates phonologically similar neighbors that compete for recognition, a process reflected in inhibitory neighborhood density effects. Sign languages provide a critical test for the g...

The transition towards a circular economy has significantly increased the use of recycled construction materials, including products intended for interior applications. While the environmental benefits of material recycling are well recognised, consi...

Agricultural compression-ignition engines require decarbonization strategies that can reduce fossil-diesel demand without replacing robust power units already operating in the field. This study experimentally evaluates an autonomous hydrous-ethanol p...

Conventional indicators such as out-of-pocket expenditure (OOP), catastrophic health expenditure (CHE), and impoverishing health expenditure (IHE) capture important dimensions of financial hardship but do not fully represent the structural conditions...