Special Issue "Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis"
Deadline for manuscript submissions: 31 May 2018
Prof. Dr. Marcello Locatelli
Department of Pharmacy, University of G. d'Annunzio Chieti and Pescara, Chieti, Italy
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Interests: analytical and Bioanalytical Chemistry; innovative (micro)extraction procedures; hyphenated instrument configurations; method validation; biological active molecules both synthetic and natural-derived
Dr. Locatelli has been an Assistant Professor at the Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara since 2008 where he teaches “Analytical Chemistry and Laboratory of Analytical Chemistry”, and “Clinical Analytical Chemistry”. He held Master's degree in chemistry in 2003, and a Ph.D. in Chemistry Sciences in 2007. He has 12 years of experience in the development and validation of innovative analytical protocols for quantification of drugs, metabolites and natural compounds. The research activity is aimed at the development and validation of chromatographic methods (according to international guidelines, ICH) for the qualitative and quantitative determination of biologically active molecules in human and animal, cosmetics, food, and environmental complex matrices. It provides, in addition, to the study of all processes related to pre-analytical stages such as sampling, extraction and purification, separation, enrichment, even the application of conventional and hyphenated analytical methods for the accurate, sensitive and selective determination of biologically active molecules. These procedures have been applied to different analytes also finding application in clinical and pre-clinical studies designed to assess the pharmacokinetic, bioequivalence and Absorption, Distribution, Metabolism and Excretion (ADME) of the formulations examined, in order to characterize new delivery systems of the active principle to improve their pharmacological properties. In the development of the method, predictive and chemometric models both are applied for the optimization of extraction protocols and for final data processing. Particular attention is given to the new instrument configurations for the quantitative analysis in complex matrix. Scientific activity was attested by more than 83 manuscripts, more than 85 congress communications, 1 patent subject to approval, and 8 book chapters, being also the guest editor for 4 special issues for international peer-reviewed journals, and coeditor of 2 books.
Prof. Dr. Simone Carradori
Deptartment of Pharmacy, University “G. d'Annunzio” of Chieti and Pescara, Chieti, Italy
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Interests: medicinal chemistry; innovative (micro)extraction procedures; microwave-assisted extraction; synthetic and natural-derived biologically active molecules; monoamine oxidase inhibitors; carbonic anhydrase inhibitors; anticancer agents; antifungal agents; anti-leishmanial and anti-Malaria compounds
Dr. Simone Carradori graduated with honors in 2003 in “Drug Chemistry and Technology”, in 2009 with honors in Pharmacy and then in “Applied Pharmaceutical Sciences” in 2016. In 2006 he completed his PhD in “Pharmaceutical Sciences” at the Laboratory of Medicinal Chemistry. In 2007 he received with honors the II level Master in "Natural Organic Substances". Dr. Carradori is an Assistant Professor at the Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara. He holds the course of “Molecular fundaments in the medicinal activities of natural products” for the II level Master in "Nutraceutical and Cosmeceutical products from natural origin", at the University of Rome "La Sapienza". He has several years of experience in the design, synthesis, extraction and isolation of biologically active compounds. The research activity is aimed at the discovery of structure-activity relationships within naturally occurring chemical scaffolds. His scientific activity is attested by more than 119 papers in peer-reviewed journals and 1 patent. He is also Co-editor-in-chief of “Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry” (Bentham Science Publishers). He is member of the Editorial Board of “Journal of Enzyme Inhibition and Medicinal Chemistry” (Taylor & Francis), “Expert Opinion on Therapeutic Patents” (Taylor & Francis), and “Current Enzyme Inhibition” (Bentham Science Publishers).
Dr. Andrei Mocan
Department of Pharmaceutical Botany, Iuliu Hațieganu University of Medicine and Pharmacy, 23 Ghe. Marinescu Street, Cluj-Napoca 400337, Romania
Interests: pharmaceutical Biology (botany); valorization of traditional medicinal and edible plants and fungi; extraction optimization of bioactive compounds from plant materials; experimental design applied to extraction and process optimization; bioactivity and chemical characterization of natural products, development of new nutraceuticals based on medicinal plants and fungi
Dr. Andrei Mocan has graduated in 2012 Pharmacy at “Iuliu Hațieganu” University of Medicine and Pharmacy from Cluj-Napoca, Romania. In February 2017 he graduated SUMMA CUM LAUDAE his PhD in “Pharmacy” by completing a joint degree between “Iuliu Hațieganu” University of Medicine and Pharmacy and the University of Hamburg, Germany. Since 2017, Dr. Mocan has been appointed a lecturer in the Faculty of Pharmacy, from “Iuliu Hațieganu” University of Medicine and Pharmacy where he teaches Pharmaceutical Botany.
Dr. Andrei Mocan has carried out his scientific works collaborating with several foreign groups as well as within several national collaborations/projects. For his results, in September 2016 he has been awarded with “The prize for excellence in scientific research” from the Romanian Society of Pharmaceutical Sciences, and in November 2017 with “The prize of excellence in Romanian Pharmaceutical Research” by the Romanian College of Pharmacists. His scientific activity is documented from about 54 papers in international peer-reviewed journals and participations in several conferences as well as national and international research grants.
Guest editor on a special issue on “Natural Enzyme Inhibitors” in South African Journal of Botany – Elsevier, guest editor on a special issue on “Antioxidant Essential Oils and Main Compounds to Treat Chronic Diseases: Current Developments and Trends” in Oxidative Medicine and Cellular Longevity –Hindawi.
Techniques that can be employed to accelerate extractions, work up, and isolation/purification of the products/metabolites, may be of interest both in the fields of natural products (food, plants, plant-derived products) and in analytical chemistry (biological matrices, clinical trials, sample preparation). In the last few years, the development of innovative procedures has deeply impacted the work of chemists.
The present Special Issue, “Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis”, aims to collect and to disseminate some of the most significant and recent contributions in the interdisciplinary area of innovative extraction procedures from complex matrices followed by validated analytical methods using hyphenated instrument configurations to support the optimization of the whole process and the scale-up possibility.
The scope is broad and includes the use of alternative (green) and/or innovative extraction techniques, optimization of the corresponding parameters by means of experimental design, development of proper solvents (ionic liquids, deep eutectic solvents, cyclodextrins), extract fractioning on the basis of specific biological activities, knowledge of the target structures in order to pursue a targeted analysis, and evaluation of the stability of intermediates/final products.
Accepted paper (both reviews and research papers) could be in the field of: - extraction procedures - hyphenated techniques - food and food supplements analyses - biological analyses - chemometric approaches. Eventually all related to specific biological activities observed.
- Abstract submission February 2018
- Paper submission 31 May 2018
- Revision (Reviewer) end of June 2018
- Revised version end of July 2018
- Final proof first days of September 2018
Prof. Dr. Marcello Locatelli
Prof. Dr. Simone Carradori
Dr. Andrei Mocan
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- hyphenated techniques
- innovative (micro)extraction procedures
- biological activities
- food and food supplements analyses
- medicinal plants and fungi
- biological analyses
- chemometric approaches