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Special Issue "Natural Product Pharmacology and Medicinal Chemistry"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 December 2018

Special Issue Editors

Guest Editor
Prof. Dr. Marcello Locatelli

Department of Pharmacy, University of G. d'Annunzio Chieti and Pescara, Chieti, Italy
Website1 | Website2 | E-Mail
Phone: +3908713554590
Interests: analytical and bioanalytical chemistry; innovative (micro)extraction procedures (MEPS, FPSE, DLLME, SULLE, MAE, etc.); hyphenated instrument configurations; method validation; bioactive compounds (drugs, drugs associations, natural-derived bioactive compounds); characterization and fingerprints; HPLC; mass spectrometry (MS and MS/MS); chemometry
Guest Editor
Prof. Dr. Simone Carradori

Department of Pharmacy, University “G. d'Annunzio” of Chieti-Pescara, Chieti, Italy
Website | E-Mail
Interests: medicinal chemistry; innovative (micro)extraction procedures; microwave-assisted extraction; synthetic and natural-derived biologically active molecules; monoamine oxidase inhibitors; carbonic anhydrase inhibitors; anticancer agents; antifungal agents; anti-leishmanial and anti-malaria compounds
Guest Editor
Dr. Andrei Mocan

Department of Pharmaceutical Botany, Iuliu Hațieganu University of Medicine and Pharmacy, 23 Ghe. Marinescu Street, Cluj-Napoca 400337, Romania
E-Mail
Interests: pharmaceutical biology (botany); valorization of traditional medicinal and edible plants and fungi; extraction optimization of bioactive compounds from plant materials; experimental design applied to extraction and process optimization; bioactivity and chemical characterization of natural products, development of new nutraceuticals based on medicinal plants and fungi, natural products as enzyme inhibitors

Special Issue Information

Dear Colleagues,

This Special Issue "Natural Product Pharmacology and Medicinal Chemistry” aims to collect and to disseminate some of the most significant and recent contributions in the interdisciplinary area of pharmacology and medicinal chemistry, namely the characterization and analysis of synthetic and natural products.

Prof. Dr. Marcello Locatelli
Prof. Dr. Simone Carradori
Dr. Andrei Mocan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmacology
  • biological assays
  • extraction procedures
  • analysis
  • instrument configuration
  • medicinal chemistry
  • new chemical entities characterization

Published Papers (1 paper)

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Review

Open AccessReview Ethnobotany, Phytochemistry and Pharmacological Effects of Plants in Genus Cynanchum Linn. (Asclepiadaceae)
Molecules 2018, 23(5), 1194; https://doi.org/10.3390/molecules23051194
Received: 28 April 2018 / Revised: 11 May 2018 / Accepted: 14 May 2018 / Published: 16 May 2018
PDF Full-text (2665 KB) | HTML Full-text | XML Full-text
Abstract
Genus Cynanchum L. belongs to the family Asclepiadaceae, which comprise more than 200 species distributed worldwide. In Chinese medical practice, numerous drugs (such as tablets and powders) containing different parts of plants of this genus are used to treat snake bites, bruises, osteoblasts,
[...] Read more.
Genus Cynanchum L. belongs to the family Asclepiadaceae, which comprise more than 200 species distributed worldwide. In Chinese medical practice, numerous drugs (such as tablets and powders) containing different parts of plants of this genus are used to treat snake bites, bruises, osteoblasts, rheumatoid arthritis and tumors. A search for original articles published on the cynanchum genus was performed by using several resources, including Flora of China Official Website and various scientific databases, such as PubMed, SciFinder, the Web of Science, Science Direct, and China Knowledge Resource Integrated (CNKI). Advances in the botanical, ethnomedicinal, phytochemical, and pharmacological studies of this genus are reviewed in this paper. Results showed that more than 440 compounds, including C21 steroids, steroidal saponins, alkaloids, flavonoids and terpene, have been isolated and identified from Cynanchum plants up to now. In vivo and in vitro studies have shown that plants possess an array of biological activities, including anti-tumor, neuroprotective and anti-fungal effects. Popular traditional prescription of Cynanchum sp. was also summed up in this paper. However, many Cynanchum species have received little or no attention. Moreover, few reports on the clinical use and toxic effects of Cynanchum sp. are available. Further attention should be focused on the study of these species to gather information on their respective toxicology data and relevant quality-control measures and clinical value of the crude extracts, active compounds, and bioactive metabolites from this genus. Further research on Cynanchum sp. should be conducted, and bioactivity-guided isolation strategies should be emphasized. In addition, systematic studies of the chemical composition of plants should be enhanced. Full article
(This article belongs to the Special Issue Natural Product Pharmacology and Medicinal Chemistry)
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