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Special Issue "Nutraceuticals and Their Medicinal Importance"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 30 August 2018

Special Issue Editor

Guest Editor
Dr. Francesca Giampieri

Department of Odontostomatologic and Specialized Clinical Sciences, Sez-Biochimica, Faculty of Medicine, Università Politecnica delle Marche, Via Ranieri 65, 60100 Ancona, Italy
Interests: nutrition; health; bioactive compounds; polyphenols; antioxidants; free radicals; oxidative stress; aging; mitochodrial functionality; apoptosis; strawberry, honey

Special Issue Information

Dear Colleagues,

The term “nutraceuticals” was introduced by Stephen DeFelice, founder and chairman of the Foundation for Innovation in Medicine, in 1989. A nutraceutical is defined as a “food, or parts of a food, that provide medical or health benefits, including the prevention and treatment of disease”. This definition includes medicinal products made from natural ingredients. Several classes of nutraceuticals have been proposed to have potential benefits in the treatment of many human pathologies, such as cardiovascular diseases, cancer, diabetes and metabolic syndrome, osteoporosis and arthritis, with consequences on quality of life and longevity. Recently, nutraceuticals have been included in conventional therapies, allowing to reduce their dosages and adverse effects. At the same time, consumers have become aware all around the world that nutraceuticals may exert specific roles at different times throughout life and may help to maintain a good health and prevent diseases. In fact, the global annual increase of nutraceutical market is of about 15%.The main aims of the Special Issue on "Nutraceuticals and Their Medicinal Importance" is to be an open forum where researchers may share their investigations and findings in this promising field and, thanks to the open access platform, increase their visibility and the chances to interact with industries and the production systems. Contributions to this issue, both in the form of original research or review articles, may cover all aspects of nutraceuticals; studies with multidisciplinary input, offering new methodologies or insights, are particularly welcome.

Dr. Francesca Giampieri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nutraceuticals
  • bioactive compounds
  • functional foods
  • medicinal products
  • health
  • disease prevention
  • quality control
  • food processing techniques
  • safety and efficacy
  • bioavailability
  • dietary supplements
  • commercialization of nutraceuticals and functional foods
  • economic and industry opportunities
  • labelling and health claims

Published Papers (1 paper)

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Open AccessArticle Comparison of Antioxidative Effects of Insect Tea and Its Raw Tea (Kuding Tea) Polyphenols in Kunming Mice
Molecules 2018, 23(1), 204; doi:10.3390/molecules23010204
Received: 11 December 2017 / Revised: 16 January 2018 / Accepted: 16 January 2018 / Published: 19 January 2018
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Kudingcha is a traditional Chinese tea, and insect tea is a special drink produced by the metabolism of insect larvae using the raw Kuding tea. Insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) are high-purity polyphenols extracted by centrifuge
[...] Read more.
Kudingcha is a traditional Chinese tea, and insect tea is a special drink produced by the metabolism of insect larvae using the raw Kuding tea. Insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) are high-purity polyphenols extracted by centrifuge precipitation. The present study was designed to compare the antioxidative effects of insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) on d-galactose-induced oxidation in Kunming (KM) mice. KM mice were treated with ITP (200 mg/kg) and KTP (200 mg/kg) by gavage, and vitamin C (VC, 200 mg/kg) was also used as a positive control by gavage. After determination in serum, liver and spleen, ITP-treated mice showed higher superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and glutathione (GSH) activities and lower nitric oxide (NO), malonaldehyde (MDA) activities than VC-treated mice, KTP-treated mice and untreated oxidation mice (control group). By H&E section observation, the mice induced by d-galactose-induced oxidation showed more changes than normal mice, and oxidative damage appeared in liver and spleen tissues; ITP, VC and KTP improved oxidative damage of liver and spleen tissues, and the effects of ITP were better than VC and KTP. Using quantitative polymerase chain reaction (qPCR) and western blot experiments, it was observed that ITP could increase the mRNA and protein expression of neuronal nitric oxide synthase (nNOS), endothelial nitric oxide synthase (eNOS), manganese superoxide dismutase (Mn-SOD), cupro/zinc superoxide dismutase (Cu/Zn-SOD), catalase (CAT), heme oxygenase-1 (HO-1), nuclear factor erythroid 2 related factor 2 (Nrf2), gamma glutamylcysteine synthetase (γ-GCS), and NAD(P)H:quinone oxidoreductase 1 (NQO1) and reduce inducible nitric oxide synthase (iNOS) expression in liver and spleen tissues compared to the control group. These effects were stronger than for VC and KTP. Both ITP and KTP had good antioxidative effects, and after the transformation of insects, the effects of ITP were better than that of KTP and even better than VC. Thus, ITP can be used as an antioxidant and anti-ageing functional food. Full article
(This article belongs to the Special Issue Nutraceuticals and Their Medicinal Importance)

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