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Molecules 2018, 23(5), 1173; https://doi.org/10.3390/molecules23051173

Tetragonia tetragonioides (Pall.) Kuntze Regulates Androgen Production in a Letrozole-Induced Polycystic Ovary Syndrome Model

Herbal Medicine Research Division, Korea Institute of Oriental Medicine (KIOM), Daejeon 34054, Korea
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Francesca Giampieri
Received: 1 April 2018 / Revised: 4 May 2018 / Accepted: 11 May 2018 / Published: 14 May 2018
(This article belongs to the Special Issue Nutraceuticals and Their Medicinal Importance)
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Abstract

Tetragonia tetragonioides (Pall.) Kuntze (TTK) is a medicinal plant traditionally used to treat various diseases such as diabetic, inflammatory, and female-related disorders. Polycystic ovary syndrome (PCOS) is a common endocrinological disorder in women of reproductive age, and hyperandrogenism is a prominent feature of PCOS resulting in anovulation and infertility. In this study, we investigated the effects of a TTK extract on androgen generation and regulation of steroidogenic enzymes in vitro and in vivo. Human adrenocortical NCI-H295R cells were used to assess the effects of TTK extract on production of dehydroepiandrosterone and testosterone, as well as the protein expression of steroidogenic enzymes. Further, a letrozole-induced PCOS rat model was used in vivo to assess whether dietary administration of TTK extract restores normal hormones and reduces PCOS symptoms. TTK extract significantly inhibited forskolin (FOR)-induced androgen production in NCI-H295R cells and serum luteinizing hormone, testosterone, and follicular cysts, but not estradiol, were reduced in letrozole-induced PCOS rats orally administered the TTK extract. In addition, TTK extract inhibits androgen biosynthesis through the ERK-CREB signaling pathway, which regulates CYP17A1 or HSD3B2 expression. TTK extract could be utilized for the prevention and treatment of hyperandrogenism and other types of PCOS. View Full-Text
Keywords: Tetragonia tetragonioides (Pall.) Kuntze; hyperandrogenism; polycystic ovary syndrome; forskolin; letrozole; steroidogenic enzymes Tetragonia tetragonioides (Pall.) Kuntze; hyperandrogenism; polycystic ovary syndrome; forskolin; letrozole; steroidogenic enzymes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Pyun, B.-J.; Yang, H.; Sohn, E.; Yu, S.Y.; Lee, D.; Jung, D.H.; Ko, B.S.; Lee, H.W. Tetragonia tetragonioides (Pall.) Kuntze Regulates Androgen Production in a Letrozole-Induced Polycystic Ovary Syndrome Model. Molecules 2018, 23, 1173.

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