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Molecules 2018, 23(4), 839; https://doi.org/10.3390/molecules23040839

A Beneficial Role of Rooibos in Diabetes Mellitus: A Systematic Review and Meta-Analysis

1
Graduate School of Nutritional Science, Sagami Women’s University, 2-1-1 Bunkyo, Minami-ku, Sagamihara, Kanagawa 252-0383, Japan
2
Faculty of Nutritional Science, Sagami Women’s University, 2-1-1 Bunkyo, Minami-ku, Sagamihara, Kanagawa 252-0383, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Francesca Giampieri
Received: 14 March 2018 / Revised: 28 March 2018 / Accepted: 5 April 2018 / Published: 6 April 2018
(This article belongs to the Special Issue Nutraceuticals and Their Medicinal Importance)
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Abstract

In a rapid increase in cases of diabetes mellitus worldwide, there has been interested in the use of plant-derived polyphenols as nutraceuticals to prevent the onset and progression of diabetes mellitus and its associated complications. Aspalathus linearis, commonly known as rooibos, is a rich source of uncommon glycosylated plant polyphenols with various critical health-promoting properties, including the prevention and treatment of diabetes mellitus (DM). This study aimed to examine these effects by meta-analyzing the current evidence in diabetic rodent models. Peer-reviewed studies written in English from two databases, PubMed and Embase, were searched up to 28 February 2018. Studies reporting blood glucose levels in diabetic rodents with and without receiving rooibos extracts or their major phenolic compounds are included. Twelve studies enrolling 88 diabetic rodents treated with rooibos extracts or their polyphenols and 85 diabetic control males reported blood glucose levels. The pooled effect size was −0.89 (95% CI: −1.44 to −0.35) with a substantial heterogeneity (I2 = 67.0%). This effect was likely to be modified by type of rooibos extracts and their polyphenols and treatment period. Blood glucose levels were significantly lower in diabetic rodent models treated with the phenolic compound rich in rooibos extracts, PPAG. View Full-Text
Keywords: rooibos extracts; diabetic rodent models; blood glucose levels; meta-analysis rooibos extracts; diabetic rodent models; blood glucose levels; meta-analysis
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Sasaki, M.; Nishida, N.; Shimada, M. A Beneficial Role of Rooibos in Diabetes Mellitus: A Systematic Review and Meta-Analysis. Molecules 2018, 23, 839.

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