Special Issue "Quorum Sensing Research in Microbial Systems"
Deadline for manuscript submissions: closed (31 May 2013)
Prof. Dr. Jun Zhu
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 211A Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104-6076, USA
Interests: bacterial pathogenesis; host-microbe interaction; signal transduction; quorum sensing; gene regulation; biofilms
Single-celled bacteria are able to produce and respond to small diffusible molecules called autoinducers. These molecules accumulate as cell density increases and regulate the expression of a range of genes to control a variety of physiological functions, in a process known as quorum sensing (QS). Many species of bacteria exchange chemical signals to help them monitor their population densities. Not long ago, it was thought that QS was a rare phenomenon limited to a few bacterial species. Recently, however, many new examples of interbacterial signaling have been reported. Among them, acyl-homoserine lactone (AHL) QS signaling systems are arguably the best-understood chemical language used by Gram-negative bacteria. QS systems fundamentally blur the distinction between unicellular and multicellular forms of life. Many QS systems are also extremely important to human health, since they regulate virulence determinants in bacterial pathogens.
Prof. Dr. Jun Zhu
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- quorum sensing
- bacterial communication
- quorum quenching
- intercellular signaling
- signal transduction
- small RNAs
Int. J. Mol. Sci. 2013, 14(5), 8841-8868; doi:10.3390/ijms14058841
Received: 28 February 2013; in revised form: 10 April 2013 / Accepted: 12 April 2013 / Published: 24 April 2013| Download PDF Full-text (377 KB) | Download XML Full-text
Article: Intra-Species Bacterial Quorum Sensing Studied at Single Cell Level in a Double Droplet Trapping System
Int. J. Mol. Sci. 2013, 14(5), 10570-10581; doi:10.3390/ijms140510570
Received: 19 April 2013; in revised form: 9 May 2013 / Accepted: 10 May 2013 / Published: 21 May 2013| Download PDF Full-text (1464 KB) | Download XML Full-text
Article: Effect of GABA, a Bacterial Metabolite, on Pseudomonas fluorescens Surface Properties and Cytotoxicity
Int. J. Mol. Sci. 2013, 14(6), 12186-12204; doi:10.3390/ijms140612186
Received: 6 May 2013; in revised form: 23 May 2013 / Accepted: 27 May 2013 / Published: 6 June 2013| Download PDF Full-text (1247 KB)
Int. J. Mol. Sci. 2013, 14(6), 12607-12619; doi:10.3390/ijms140612607
Received: 17 May 2013; in revised form: 31 May 2013 / Accepted: 4 June 2013 / Published: 17 June 2013| Download PDF Full-text (429 KB)
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Article
Title: Quorum sensing in Yersinia enterocolitica
Author: Stephen C. Winans
Affiliation: Departments of Microbiology, Cornell University, Ithaca, NY 14853, USA; E-Mail: firstname.lastname@example.org
Abstract: Yersinia enterocolitica is a human pathogen that causes yersiniosis, and is related to Yersinia pestis, which causes bubonic plague. These organisms encode highly similar cell-cell communication systems. In Y. enterocolitica, YenI synthesizes the pheromone 3-oxo-hexanoyl homoserine lactone (OHHL), while YenR is an OHHL receptor and transcription factor. YenR functions only in the absence of OHHL. Apo-YenR activates transcription of a small nocoding RNA (sRNA) called YenS, which is partially complementary to the YenI mRNA. Activation of the yenS gene at low cell densities therefore inhibits YenI protein synthesis and OHHL accumulation. Inhibition of yenS transcription at high cell density causes elevated YenI synthesis and elevated OHHL accumulation. This is predicted to create a bi-stable switch with an unstable intermediate. YenS also plays a positive role in swarming motility across a semisolid agar surface. A second sRNA, YenT is partially complementary to YenS, and inhibits YenS function, probably by forming a double-stranded molecule in the region of complementarity.
Last update: 26 February 2013