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Structural Insights into a Novel Interkingdom Signaling Circuit by Cartography of the Ligand-Binding Sites of the Homologous Quorum Sensing LuxR-Family
Int. J. Mol. Sci. 2014, 15(1), 654-669; doi:10.3390/ijms15010654

Acyl-Homoserine Lactone Quorum Sensing in the Roseobacter Clade

3,*  and 1,*
1 Institute of Marine and Environmental Technology, University of Maryland Center for Environmental Science, 701 E Pratt St., Baltimore, MD 21202, USA 2 Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave, Madison, WI 53706, USA 3 Department of Biology, Indiana University, 1001 E. 3rd St., Jordan Hall 142, Bloomington, IN 47405, USA Current address: Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
* Authors to whom correspondence should be addressed.
Received: 28 October 2013 / Revised: 15 December 2013 / Accepted: 18 December 2013 / Published: 7 January 2014
(This article belongs to the Special Issue Quorum Sensing Research in Microbial Systems)
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Members of the Roseobacter clade are ecologically important and numerically abundant in coastal environments and can associate with marine invertebrates and nutrient-rich marine snow or organic particles, on which quorum sensing (QS) may play an important role. In this review, we summarize current research progress on roseobacterial acyl-homoserine lactone-based QS, particularly focusing on three relatively well-studied representatives, Phaeobacter inhibens DSM17395, the marine sponge symbiont Ruegeria sp. KLH11 and the dinoflagellate symbiont Dinoroseobacter shibae. Bioinformatic survey of luxI homologues revealed that over 80% of available roseobacterial genomes encode at least one luxI homologue, reflecting the significance of QS controlled regulatory pathways in adapting to the relevant marine environments. We also discuss several areas that warrant further investigation, including studies on the ecological role of these diverse QS pathways in natural environments.
Keywords: Quorum sensing; signaling; symbiont; LuxI homologue; Ruegeria; Phaeobacter; Dinoroseobacter Quorum sensing; signaling; symbiont; LuxI homologue; Ruegeria; Phaeobacter; Dinoroseobacter
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Zan, J.; Liu, Y.; Fuqua, C.; Hill, R.T. Acyl-Homoserine Lactone Quorum Sensing in the Roseobacter Clade. Int. J. Mol. Sci. 2014, 15, 654-669.

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