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Int. J. Mol. Sci. 2013, 14(10), 19976-19986; doi:10.3390/ijms141019976
Article

N,N’-alkylated Imidazolium-Derivatives Act as Quorum-Sensing Inhibitors Targeting the Pectobacterium atrosepticum-Induced Symptoms on Potato Tubers

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Received: 31 May 2013; in revised form: 16 September 2013 / Accepted: 17 September 2013 / Published: 8 October 2013
(This article belongs to the Special Issue Quorum Sensing Research in Microbial Systems)
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Abstract: Bacteria belonging to the Pectobacterium genus are the causative agents of the blackleg and soft-rot diseases that affect potato plants and tubers worldwide. In Pectobacterium, the expression of the virulence genes is controlled by quorum-sensing (QS) and N-acylhomoserine lactones (AHLs). In this work, we screened a chemical library of QS-inhibitors (QSIs) and AHL-analogs to find novel QSIs targeting the virulence of Pectobacterium. Four N,N’-bisalkylated imidazolium salts were identified as QSIs; they were active at the µM range. In potato tuber assays, two of them were able to decrease the severity of the symptoms provoked by P. atrosepticum. This work extends the range of the QSIs acting on the Pectobacterium-induced soft-rot disease.
Keywords: N-acylhomoserine lactone; quorum-sensing; quorum-sensing inhibitor; Pectobacterium; soft-rot; potato tuber N-acylhomoserine lactone; quorum-sensing; quorum-sensing inhibitor; Pectobacterium; soft-rot; potato tuber
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

des Essarts, Y.R.; Sabbah, M.; Comte, A.; Soulère, L.; Queneau, Y.; Dessaux, Y.; Hélias, V.; Faure, D. N,N’-alkylated Imidazolium-Derivatives Act as Quorum-Sensing Inhibitors Targeting the Pectobacterium atrosepticum-Induced Symptoms on Potato Tubers. Int. J. Mol. Sci. 2013, 14, 19976-19986.

AMA Style

des Essarts YR, Sabbah M, Comte A, Soulère L, Queneau Y, Dessaux Y, Hélias V, Faure D. N,N’-alkylated Imidazolium-Derivatives Act as Quorum-Sensing Inhibitors Targeting the Pectobacterium atrosepticum-Induced Symptoms on Potato Tubers. International Journal of Molecular Sciences. 2013; 14(10):19976-19986.

Chicago/Turabian Style

des Essarts, Yannick R.; Sabbah, Mohamad; Comte, Arnaud; Soulère, Laurent; Queneau, Yves; Dessaux, Yves; Hélias, Valérie; Faure, Denis. 2013. "N,N’-alkylated Imidazolium-Derivatives Act as Quorum-Sensing Inhibitors Targeting the Pectobacterium atrosepticum-Induced Symptoms on Potato Tubers." Int. J. Mol. Sci. 14, no. 10: 19976-19986.


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