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The Organization of the Quorum Sensing luxI/R Family Genes in Burkholderia
International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, Trieste 32149, Italy
Faculty of Information Technology, PázmányPéter Catholic University, Práter u. 50/a, Budapest 1083, Hungary
The Capes Foundation, Ministry of Education of Brazil, Cx postal 250, Brasilia, DF 70.040-020, Brazil
* Authors to whom correspondence should be addressed.
Received: 30 May 2013; in revised form: 20 June 2013 / Accepted: 24 June 2013 / Published: 2 July 2013
Abstract: Members of the Burkholderia genus of Proteobacteria are capable of living freely in the environment and can also colonize human, animal and plant hosts. Certain members are considered to be clinically important from both medical and veterinary perspectives and furthermore may be important modulators of the rhizosphere. Quorum sensing via N-acyl homoserine lactone signals (AHL QS) is present in almost all Burkholderia species and is thought to play important roles in lifestyle changes such as colonization and niche invasion. Here we present a census of AHL QS genes retrieved from public databases and indicate that the local arrangement (topology) of QS genes, their location within chromosomes and their gene neighborhoods show characteristic patterns that differ between the known Burkholderia clades. In sequence phylogenies, AHL QS genes seem to cluster according to the local gene topology rather than according to the species, which suggests that the basic topology types were present prior to the appearance of current Burkholderia species. The data are available at http://net.icgeb.org/burkholderia/.
Keywords: quorum sensing; N-AHL; local topologies; chromosomal arrangements; Burkholderia
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Choudhary, K.S.; Hudaiberdiev, S.; Gelencsér, Z.; Gonçalves Coutinho, B.; Venturi, V.; Pongor, S. The Organization of the Quorum Sensing luxI/R Family Genes in Burkholderia. Int. J. Mol. Sci. 2013, 14, 13727-13747.
Choudhary KS, Hudaiberdiev S, Gelencsér Z, Gonçalves Coutinho B, Venturi V, Pongor S. The Organization of the Quorum Sensing luxI/R Family Genes in Burkholderia. International Journal of Molecular Sciences. 2013; 14(7):13727-13747.
Choudhary, Kumari S.; Hudaiberdiev, Sanjarbek; Gelencsér, Zsolt; Gonçalves Coutinho, Bruna; Venturi, Vittorio; Pongor, Sándor. 2013. "The Organization of the Quorum Sensing luxI/R Family Genes in Burkholderia." Int. J. Mol. Sci. 14, no. 7: 13727-13747.