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Development of Quorum-Based Anti-Virulence Therapeutics Targeting Gram-Negative Bacterial Pathogens
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore
* Author to whom correspondence should be addressed.
Received: 10 July 2013; in revised form: 25 July 2013 / Accepted: 1 August 2013 / Published: 9 August 2013
Abstract: Quorum sensing is a cell density-dependent signaling phenomenon used by bacteria for coordination of population-wide phenotypes, such as expression of virulence genes, antibiotic resistance and biofilm formation. Lately, disruption of bacterial communication has emerged as an anti-virulence strategy with enormous therapeutic potential given the increasing incidences of drug resistance in pathogenic bacteria. The quorum quenching therapeutic approach promises a lower risk of resistance development, since interference with virulence generally does not affect the growth and fitness of the bacteria and, hence, does not exert an associated selection pressure for drug-resistant strains. With better understanding of bacterial communication networks and mechanisms, many quorum quenching methods have been developed against various clinically significant bacterial pathogens. In particular, Gram-negative bacteria are an important group of pathogens, because, collectively, they are responsible for the majority of hospital-acquired infections. Here, we discuss the current understanding of existing quorum sensing mechanisms and present important inhibitory strategies that have been developed against this group of pathogenic bacteria.
Keywords: quorum sensing; anti-virulence; Gram-negative; quorum quenching; bacterial communication; N-acylhomoserine lactone; bacterial pathogens; disruption; inhibition
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Tay, S.B.; Yew, W.S. Development of Quorum-Based Anti-Virulence Therapeutics Targeting Gram-Negative Bacterial Pathogens. Int. J. Mol. Sci. 2013, 14, 16570-16599.
Tay SB, Yew WS. Development of Quorum-Based Anti-Virulence Therapeutics Targeting Gram-Negative Bacterial Pathogens. International Journal of Molecular Sciences. 2013; 14(8):16570-16599.
Tay, Song B.; Yew, Wen S. 2013. "Development of Quorum-Based Anti-Virulence Therapeutics Targeting Gram-Negative Bacterial Pathogens." Int. J. Mol. Sci. 14, no. 8: 16570-16599.