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Int. J. Mol. Sci. 2013, 14(8), 16473-16484; doi:10.3390/ijms140816473
Article

A Nitric Oxide-Responsive Quorum Sensing Circuit in Vibrio harveyi Regulates Flagella Production and Biofilm Formation

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Received: 4 June 2013; Accepted: 26 July 2013 / Published: 8 August 2013
(This article belongs to the Special Issue Quorum Sensing Research in Microbial Systems)
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Abstract: Cell signaling plays an important role in the survival of bacterial colonies. They use small molecules to coordinate gene expression in a cell density dependent manner. This process, known as quorum sensing, helps bacteria regulate diverse functions such as bioluminescence, biofilm formation and virulence. In Vibrio harveyi, a bioluminescent marine bacterium, four parallel quorum-sensing systems have been identified to regulate light production. We have previously reported that nitric oxide (NO), through the H-NOX/HqsK quorum sensing pathway contributes to light production in V. harveyi through the LuxU/LuxO/LuxR quorum sensing pathway. In this study, we show that nitric oxide (NO) also regulates flagellar production and enhances biofilm formation. Our data suggest that V. harveyi is capable of switching between lifestyles to be able to adapt to changes in the environment.
Keywords: nitric oxide; biofilm; quorum sensing; flagella; bacterial motility; H-NOX nitric oxide; biofilm; quorum sensing; flagella; bacterial motility; H-NOX
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Henares, B.M.; Xu, Y.; Boon, E.M. A Nitric Oxide-Responsive Quorum Sensing Circuit in Vibrio harveyi Regulates Flagella Production and Biofilm Formation. Int. J. Mol. Sci. 2013, 14, 16473-16484.

AMA Style

Henares BM, Xu Y, Boon EM. A Nitric Oxide-Responsive Quorum Sensing Circuit in Vibrio harveyi Regulates Flagella Production and Biofilm Formation. International Journal of Molecular Sciences. 2013; 14(8):16473-16484.

Chicago/Turabian Style

Henares, Bernadette M.; Xu, Yueming; Boon, Elizabeth M. 2013. "A Nitric Oxide-Responsive Quorum Sensing Circuit in Vibrio harveyi Regulates Flagella Production and Biofilm Formation." Int. J. Mol. Sci. 14, no. 8: 16473-16484.



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