Deadline for manuscript submissions: closed (30 December 2009)
Special Issue Editor
Guest Editor Dr. Luis Menéndez-Arias
Centro de Biología Molecular "Severo Ochoa" [Consejo Superior de Investigaciones Científicas (CSIC) & Universidad Autónoma de Madrid], c/ Nicolás Cabrera 1, Campus de Cantoblanco, 28049 Madrid, Spain
Website: https://cordis.europa.eu/partners/web/lmenendezarias Phone: +34 911964494 Interests: HIV; reverse transcription; drug resistance; genetic variation; proteolytic processing; HIV protease
Special Issue Information
The retroviral RNA genome encodes for three enzymes essential for virus replication: (i) the viral protease (PR), that converts the immature virion into a mature virus through the cleavage of precursor polypeptides; (ii) the reverse transcriptase (RT), responsible for the conversion of the single-stranded genomic RNA into double-stranded proviral DNA; and (iii) the integrase (IN) that inserts the proviral DNA into the host cell genome. All of them are important targets for therapeutic intervention. Knowledge on their structure and mechanism of action should help us to design better drugs against AIDS and other diseases caused by retroviruses.