Special Issue "Retroviral Enzymes"

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A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: closed (30 December 2009)

Special Issue Editor

Guest Editor
Dr. Luis Menéndez-Arias
Centro de Biología Molecular "Severo Ochoa" [Consejo Superior de Investigaciones Científicas (CSIC) & Universidad Autónoma de Madrid], c/ Nicolás Cabrera 1, Campus de Cantoblanco, 28049 Madrid, Spain
Website: https://cordis.europa.eu/partners/web/lmenendezarias
E-Mail: lmenendez@cbm.uam.es
Phone: +34 91 196 4494
Interests: HIV; reverse transcription; drug resistance; genetic variation; proteolytic processing; HIV protease

Special Issue Information

Dear Colleagues,

The retroviral RNA genome encodes for three enzymes essential for virus replication: (i) the viral protease (PR), that converts the immature virion into a mature virus through the cleavage of precursor polypeptides; (ii) the reverse transcriptase (RT), responsible for the conversion of the single-stranded genomic RNA into double-stranded proviral DNA; and (iii) the integrase (IN) that inserts the proviral DNA into the host cell genome. All of them are important targets for therapeutic intervention. Knowledge on their structure and mechanism of action should help us to design better drugs against AIDS and other diseases caused by retroviruses.

Dr. Luis Menéndez-Arias
Guest Editor

Keywords

  • aspartyl-proteases
  • reverse transcription
  • integration
  • virus maturation
  • antiretroviral drugs
  • drug targets
  • viral mutation and variability

Published Papers (15 papers)

Viruses 2010, 2(5), 1181-1184; doi:10.3390/v2051181
Received: 5 May 2010; Accepted: 7 May 2010 / Published: 7 May 2010
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Viruses 2010, 2(5), 1110-1145; doi:10.3390/v2051110
Received: 25 March 2010; in revised form: 2 May 2010 / Accepted: 3 May 2010 / Published: 5 May 2010
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Viruses 2010, 2(4), 939-960; doi:10.3390/v2040939
Received: 4 February 2010; in revised form: 3 March 2010 / Accepted: 1 April 2010 / Published: 2 April 2010
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Viruses 2010, 2(4), 900-926; doi:10.3390/v2040900
Received: 28 January 2010; in revised form: 22 March 2010 / Accepted: 24 March 2010 / Published: 30 March 2010
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Viruses 2010, 2(2), 606-638; doi:10.3390/v2020606
Received: 2 December 2009; in revised form: 22 January 2010 / Accepted: 3 February 2010 / Published: 11 February 2010
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Viruses 2010, 2(1), 213-243; doi:10.3390/v2010213
Received: 7 October 2009; in revised form: 8 January 2010 / Accepted: 13 January 2010 / Published: 18 January 2010
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Viruses 2010, 2(1), 147-165; doi:10.3390/v2010147
Received: 7 October 2009; in revised form: 12 January 2010 / Accepted: 13 January 2010 / Published: 14 January 2010
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Viruses 2010, 2(1), 111-130; doi:10.3390/v2010111
Received: 8 October 2009; in revised form: 21 December 2009 / Accepted: 5 January 2010 / Published: 12 January 2010
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Viruses 2009, 1(3), 1209-1239; doi:10.3390/v1031209
Received: 8 October 2009; in revised form: 7 December 2009 / Accepted: 7 December 2009 / Published: 11 December 2009
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Viruses 2009, 1(3), 1137-1165; doi:10.3390/v1031137
Received: 20 October 2009; in revised form: 3 December 2009 / Accepted: 3 December 2009 / Published: 4 December 2009
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Viruses 2009, 1(3), 1110-1136; doi:10.3390/v1031110
Received: 1 October 2009; in revised form: 30 November 2009 / Accepted: 1 December 2009 / Published: 3 December 2009
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Viruses 2009, 1(3), 873-894; doi:10.3390/v1030873
Received: 30 September 2009; in revised form: 6 November 2009 / Accepted: 9 November 2009 / Published: 10 November 2009
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Viruses 2009, 1(3), 780-801; doi:10.3390/v1030780
Received: 12 October 2009; in revised form: 28 October 2009 / Accepted: 6 November 2009 / Published: 6 November 2009
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Viruses 2009, 1(3), 713-736; doi:10.3390/v1030713
Received: 30 September 2009; in revised form: 3 November 2009 / Accepted: 4 November 2009 / Published: 5 November 2009
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Viruses 2009, 1(3), 657-677; doi:10.3390/v1030657
Received: 10 September 2009; in revised form: 28 October 2009 / Accepted: 4 November 2009 / Published: 4 November 2009
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Last update: 5 March 2014

Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert