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Viruses 2009, 1(3), 873-894; doi:10.3390/v1030873
Review

Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription

1,2
, 1
, 1,3
 and 1,3,*
Received: 30 September 2009; in revised form: 6 November 2009 / Accepted: 9 November 2009 / Published: 10 November 2009
(This article belongs to the Special Issue Retroviral Enzymes)
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Abstract: There is ample evidence that synthesis of HIV-1 proviral DNA from the viral RNA genome during reverse transcription requires host factors. However, only a few cellular proteins have been described in detail that affect reverse transcription and interact with reverse transcriptase (RT). HIV-1 integrase is an RT binding protein and a number of IN-binding proteins including INI1, components of the Sin3a complex, and Gemin2 affect reverse transcription. In addition, recent studies implicate the cellular proteins HuR, AKAP149, and DNA topoisomerase I in reverse transcription through an interaction with RT. In this review we will consider interactions of reverse transcription complex with viral and cellular factors and how they affect the reverse transcription process.
Keywords: HIV-1; reverse transcriptase; HuR; AKAP149; DNA topoisomerase I; Sin3a; HDAC1; SAP18; SAP; SMN; Gemin2; lysl-tRNA synthetase; INI1; DHX9; APOBEC3G HIV-1; reverse transcriptase; HuR; AKAP149; DNA topoisomerase I; Sin3a; HDAC1; SAP18; SAP; SMN; Gemin2; lysl-tRNA synthetase; INI1; DHX9; APOBEC3G
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Warren, K.; Warrilow, D.; Meredith, L.; Harrich, D. Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription. Viruses 2009, 1, 873-894.

AMA Style

Warren K, Warrilow D, Meredith L, Harrich D. Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription. Viruses. 2009; 1(3):873-894.

Chicago/Turabian Style

Warren, Kylie; Warrilow, David; Meredith, Luke; Harrich, David. 2009. "Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription." Viruses 1, no. 3: 873-894.


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