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Viruses 2009, 1(3), 713-736; doi:10.3390/v1030713

HIV-1 Integrase-DNA Recognition Mechanisms

Center for Retrovirus Research and Comprehensive Cancer Center, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
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Received: 30 September 2009 / Revised: 3 November 2009 / Accepted: 4 November 2009 / Published: 5 November 2009
(This article belongs to the Special Issue Retroviral Enzymes)
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Abstract

Integration of a reverse transcribed DNA copy of the HIV viral genome into the host chromosome is essential for virus replication. This process is catalyzed by the virally encoded protein integrase. The catalytic activities, which involve DNA cutting and joining steps, have been recapitulated in vitro using recombinant integrase and synthetic DNA substrates. Biochemical and biophysical studies of these model reactions have been pivotal in advancing our understanding of mechanistic details for how IN interacts with viral and target DNAs, and are the focus of the present review.
Keywords: HIV; retroviruses; DNA; integrase; crosslinking; footprinting HIV; retroviruses; DNA; integrase; crosslinking; footprinting
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kessl, J.J.; McKee, C.J.; Eidahl, J.O.; Shkriabai, N.; Katz, A.; Kvaratskhelia, M. HIV-1 Integrase-DNA Recognition Mechanisms. Viruses 2009, 1, 713-736.

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