CiteULike
Facebook
Mendeley
Twitter
This article is- freely available
- re-usable
Viruses 2009, 1(3), 713-736; doi:10.3390/v1030713
Review
HIV-1 Integrase-DNA Recognition Mechanisms
Jacques J. Kessl
, Christopher J. McKee, Jocelyn O. Eidahl, Nikolozi Shkriabai, Ari Katz and Mamuka Kvaratskhelia*
, Christopher J. McKee, Jocelyn O. Eidahl, Nikolozi Shkriabai, Ari Katz and Mamuka Kvaratskhelia*
Center for Retrovirus Research and Comprehensive Cancer Center, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
* Author to whom correspondence should be addressed.
Received: 30 September 2009; in revised form: 3 November 2009 / Accepted: 4 November 2009 / Published: 5 November 2009
(This article belongs to the Special Issue Retroviral Enzymes)
Download PDF Full-Text [336 KB, uploaded 5 November 2009 14:33 CET]
Abstract: Integration of a reverse transcribed DNA copy of the HIV viral genome into the host chromosome is essential for virus replication. This process is catalyzed by the virally encoded protein integrase. The catalytic activities, which involve DNA cutting and joining steps, have been recapitulated in vitro using recombinant integrase and synthetic DNA substrates. Biochemical and biophysical studies of these model reactions have been pivotal in advancing our understanding of mechanistic details for how IN interacts with viral and target DNAs, and are the focus of the present review.
Keywords: HIV; retroviruses; DNA; integrase; crosslinking; footprinting
Article Statistics
Click here to load and display the download statistics.Cite This Article
MDPI and ACS Style
Kessl, J.J.; McKee, C.J.; Eidahl, J.O.; Shkriabai, N.; Katz, A.; Kvaratskhelia, M. HIV-1 Integrase-DNA Recognition Mechanisms. Viruses 2009, 1, 713-736.
AMA StyleKessl JJ, McKee CJ, Eidahl JO, Shkriabai N, Katz A, Kvaratskhelia M. HIV-1 Integrase-DNA Recognition Mechanisms. Viruses. 2009; 1(3):713-736.
Chicago/Turabian StyleKessl, Jacques J.; McKee, Christopher J.; Eidahl, Jocelyn O.; Shkriabai, Nikolozi; Katz, Ari; Kvaratskhelia, Mamuka. 2009. "HIV-1 Integrase-DNA Recognition Mechanisms." Viruses 1, no. 3: 713-736.